WS3

ChemicalBook > CAS DataBase List > WS3

Product Name: WS3
CAS No.: 1421227-52-2
Chemical Name: WS3
Synonyms: CS-1800;WS-3; WS 3;WS3, >=98%;WS3 USP/EP/BP;WS3, 1421227-52-2;insulin,pancreatic,pigment,WS3,proliferation,epithelial,β cell,WS 3,WS-3,Inhibitor,R7T1,diabete,RPE,inhibit,retinal;N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE;N-(6-{4-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbamoyl)amino]phenoxy}pyrimidin-4-yl)cyclopropanecarboxamide;N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide;Cyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-
CBNumber: CB12723012
Molecular Formula: C28H30F3N7O3
Formula Weight: 569.58
MOL File: 1421227-52-2.mol

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WS3 Property

Boiling point:: 632.9±55.0 °C(Predicted)
Density: 1.423±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 11.82±0.20(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0758
Product name: WS3
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $546
Updated: 2023/01/07

Sigma-Aldrich

Product number: SML0758
Product name: WS3
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $125
Updated: 2022/05/15

Cayman Chemical

Product number: 17667
Product name: WS-3
Purity: ≥95%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 17667
Product name: WS-3
Purity: ≥95%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17667
Product name: WS-3
Purity: ≥95%
Packaging: 25mg
Price: $254
Updated: 2024/03/01

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WS3 Chemical Properties,Usage,Production

Uses

WS3 is a β-cell proliferation indocer via the IκB kinase pathway and modulation of the Erb3 binding-protein. Potential treatment and cure for diabetes type I.

Biological Activity

ws 3 is an agonist of trpm8 receptor with ec50 value of 3.7 μm [1].transient receptor potential cation channel subfamily m member 8 (trpm8) is a ca2+- and na+-permeable ion channel and is activated by cooling agents and cold temperatures. trpm8 belongs to trp family and is expressed in sensory neurons.ws 3 is an agonist of trpm8 receptor and a cooling agent. in hek293 cells expressed recombinant mouse trpm8, ws 3 (30 μm) increased [ca2+]i. ws 3 exhibited potency with ec50 value of 3.7 μm and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. in hek cells stably expressing either htrpm8 or htrpa1, ws 3 activated htrpm8 and htrpa1 with ec50 values of 2.2 and 120.6 μm, respectively. ws 3 was efficacious in eliciting cooling sensation [2].

References

[1]. behrendt hj, germann t, gillen c, et al. characterization of the mouse cold-menthol receptor trpm8 and vanilloid receptor type-1 vr1 using a fluorometric imaging plate reader (flipr) assay. br j pharmacol, 2004, 141(4): 737-745.
[2]. klein ah, iodi carstens m, mccluskey ts, et al. novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. chem senses, 2011, 36(7): 649-658.

WS3 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from WS3 manufacturers

Career Henan Chemical Co

Product: N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE 1421227-52-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 2kg
Release date: 2019-09-05

1421227-52-2, WS3Related Search:

WY-14643 Wnt-C59 WWL229 Wnt Agonist WS6 WS-383 WS 12 Pifithrin-α (PFTα) SB216763 Belnacasan (VX-765) Bosutinib Saracatinib Z-VAD-FMK

N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide

WS-3; WS 3

CS-1800

N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide WS3

WS3 N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE

WS3, 1421227-52-2

WS3, >=98%

N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE

Cyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-

N-(6-{4-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbamoyl)amino]phenoxy}pyrimidin-4-yl)cyclopropanecarboxamide

WS3 USP/EP/BP

insulin,pancreatic,pigment,WS3,proliferation,epithelial,β cell,WS 3,WS-3,Inhibitor,R7T1,diabete,RPE,inhibit,retinal

1421227-52-2

C28H30F3N7O3

Inhibitors

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