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PD-L1 inhibitor 1

Product Name
PD-L1 inhibitor 1
CAS No.
1675203-84-5
Chemical Name
PD-L1 inhibitor 1
Synonyms
BMS-202;CS-2416;PD1 inhibitor 2;PD 1 inhibitor 2;PD-1 inhibitor 2;PD-L1 inhibitor 2;PD-L1 inhibitor 1;PD1-PDL1 inhibitor 2;PD-1/PD-L1 inhibitor 2(BMS-202);BMS202 (PD-1/PD-L1 inhibitor 2)
CBNumber
CB13043328
Molecular Formula
C25H29N3O3
Formula Weight
419.52
MOL File
1675203-84-5.mol
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PD-L1 inhibitor 1 Property

Boiling point:
611.4±55.0 °C(Predicted)
Density 
1.133±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form 
solid
pka
16.06±0.46(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
19132
Product name
PD-1/PD-L1 Inhibitor 2
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19132
Product name
PD-1/PD-L1 Inhibitor 2
Purity
≥98%
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
19132
Product name
PD-1/PD-L1 Inhibitor 2
Purity
≥98%
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
19132
Product name
PD-1/PD-L1 Inhibitor 2
Purity
≥98%
Packaging
25mg
Price
$576
Updated
2024/03/01
TRC
Product number
B695175
Product name
BMS-202
Packaging
10mg
Price
$310
Updated
2021/12/16
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PD-L1 inhibitor 1 Chemical Properties,Usage,Production

Description

The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM.

Uses

BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface.

References

1) Zak?et al.?(2016),?Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1);?Oncotarget?7?30323 2) Guzik?et al.?(2017),?Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1;?J. Med. Chem.?60?5857

PD-L1 inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD-L1 inhibitor 1 Suppliers

China 80 India 1 United States 16 Global 97
MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn
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View Lastest Price from PD-L1 inhibitor 1 manufacturers

Career Henan Chemical Co
Product
PD-L1 inhibitor 1 1675203-84-5
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg,10kg,100kg
Release date
2020-01-09

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  • PD-L1 inhibitor 1
  • PD1-PDL1 inhibitor 2
  • N-[2-[[[2-Methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]acetamide
  • BMS-202
  • Acetamide, N-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]-
  • PD 1 inhibitor 2
  • PD1 inhibitor 2
  • PD-1 inhibitor 2
  • PD-L1 inhibitor 2
  • PD-L1 INHIBITOR 2;PD-1 INHIBITOR 2;PD1 INHIBITOR 2;PD 1 INHIBITOR 2;BMS 202;BMS202
  • PD-1/PD-L1 inhibitor 2(BMS-202)
  • CS-2416
  • N-{2-[({2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide
  • PD1 INHIBITOR 2;PD 1 INHIBITOR 2;BMS202;BMS 202
  • BMS202 (PD-1/PD-L1 inhibitor 2)
  • N-(2-(((2-Methoxy-6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)pyridin-3-yl)methyl)amino)ethyl)acetamide
  • BMS202 (PD-1/PD-L1 inhibitor 2), small-molecule inhibitor
  • 1675203-84-5