Propafenone Hydrochloride

ChemicalBook > CAS DataBase List > Propafenone Hydrochloride

Propafenone Hydrochloride

Product Name: Propafenone Hydrochloride
CAS No.: 34183-22-7
Chemical Name: Propafenone Hydrochloride
Synonyms: PROPAFENONE HCL;Pronon;Rythmol;rytmonorm;SA-79 (hydrochloride);1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI);sa79;wz884;Ropaful;Sobiral
CBNumber: CB1311105
Molecular Formula: C21H28ClNO3
Formula Weight: 377.9
MOL File: 34183-22-7.mol

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Propafenone Hydrochloride Property

Melting point:: 165-1670C
storage temp.: 2-8°C
solubility: Slightly soluble in cold water, soluble in methanol and in hot water, practically insoluble in ethanol (96 per cent).
color: White to Off-White
λmax: 303nm(MeOH)(lit.)
Merck: 14,7794
CAS DataBase Reference: 34183-22-7(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xn
Risk Statements: 46-22
Safety Statements: 53-36/37/39-45
WGK Germany: 3
RTECS: UH2833000
HS Code: 2922504500
Toxicity: LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P4670
Product name: Propafenone hydrochloride
Packaging: 5g
Price: $147
Updated: 2024/03/01

Sigma-Aldrich

Product number: P-148
Product name: Propafenonehydrochloridesolution
Purity: 1?mg/mLinmethanol((asfreebase)),certifiedreferencematerial,ampuleof1?
Packaging: 1ML
Price: $149
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1570304
Product name: Propafenone hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: P2301
Product name: Propafenone Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21871
Product name: Propafenone (hydrochloride)
Purity: ≥98%
Packaging: 1g
Price: $32
Updated: 2024/03/01

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Propafenone Hydrochloride Chemical Properties,Usage,Production

Description

Propafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.
Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.

Chemical Properties

White Solid

Uses

Propafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.

Uses

Sodium channel blocker. Antiarrhythmic (class IC)

Definition

ChEBI: Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).

brand name

Rythmol (Reliant).

Pharmacokinetics

Propafenone hydrochloride (Rythmol(R)) is similar in action to flecainide. It reduces the fast inward sodium current in Purkinje fibres and to a lesser extent in myocardial fibres. Unlike other class l drugs, propafenone has mild B-blocking effects. This may contribute to its overall effects on the conduction system. lt is also believed to have calcium channel-blocking effects, which may contribute to its mild negative inotropic effects.

Clinical Use

Anti-arrhythmic agent:
Ventricular arrhythmias
Paroxysmal supraventricular tachyarrhythmias, (including paroxysmal atrial flutter or fibrillation, and paroxysmal re-entrant tachycardias involving the AV node or accessory pathway) where standard therapy has failed or is unsuitable

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased myocardial depression with other anti-arrhythmics.
Antibacterials: increased metabolism with rifampicin (reduced effect).
Anticoagulants: enhanced anticoagulant effect of coumarins.
Antidepressants: increased risk of arrhythmias with tricyclics; metabolism of propafenone possibly inhibited by paroxetine (increased risk of toxicity).
Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid.
Antipsychotics: increased risk of ventricular arrhythmias with antipsychotics that prolong the QT interval.
Antivirals: concentration of propafenone increased by saquinavir and ritonavir and possibly by fosamprenavir, increased risk of ventricular arrhythmias - avoid; use with caution with telaprevir.
Beta-blockers: increased myocardial depression; increased concentration of metoprolol and propranolol.
Cardiac glycosides: increased digoxin concentration - halve digoxin dose.
Ciclosporin: possibly increased ciclosporin concentration.
Ulcer-healing drugs: levels increased by cimetidine.

Metabolism

Propafenone is hepatically metabolised mainly by CYP2D6 isoenzyme but also to a small extent by CYP1A2 and CYP3A4. This forms 2 active metabolites, 5-hydroxypropafenone and N-depropylpropafenone and some inactive ones. Propafenone and its metabolites also undergo glucuronidation. The extent of metabolism is genetically determined.
Propafenone is excreted in the urine and faeces mainly in the form of conjugated metabolites.

Propafenone Hydrochloride Preparation Products And Raw materials

Raw materials

Benzaldehyde 2'-Hydroxyacetophenone

Preparation Products

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Propafenone Hydrochloride Suppliers

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View Lastest Price from Propafenone Hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Propafenone Hydrochloride 34183-22-7
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-11

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Propafenone Hydrochloride 34183-22-7
Price: US $100.00-1000.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Propafenone 34183-22-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg/month
Release date: 2021-07-22

34183-22-7, Propafenone HydrochlorideRelated Search:

Pramipexole Impurity 4 PROTRIPTYLINE HYDROCHLORIDE 1-(2,6-Dimethylphenoxy)-2-propanamine Losartan potassium Rivaroxaban Bortezomib Glimepiride JNK-IN-8 Nisoldipine Flavopiridol (Alvocidib) HCl Lidocaine Propafenone Hydrochloride Propafenone Plerixafor 8HCl (AMD3100 8HCl) Propranolol hydrochloride Pramipexole dihydrochloride monohydrate 5-HYDROXY PROPAFENONE HYDROCHLORIDE (R)-(+)-PROPAFENONE HYDROCHLORIDE

1-[2-(2-HYDROXY-3-[PROPYLAMINO]-PROPOXY)PHENYL]-3-PHENYL-1-PROPANONE HYDROCHLORIDE

1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride

PROPAFENONE HCL

rytmonorm

sa79

wz884

Arythmol

Pronon

Rythmol

Rytmonor

1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI)

Propiophenone, 2'-[2-hydroxy-3-(propylamino)propoxy]-3-phenyl-, hydrochloride (8CI)

Propafenone Impurity 9

PROPAFENONE HYDROCHLORIDE

1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanonhydroc

2’-(2-hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenonehydrochloride

2’-(2-hydroxy-3-(propylamino)propoxy)-3-phenyl-propiophenonhydrochloride

baxarytmon

fenoprain

propafenonhydrochlorid

rhythmonorm

SA-79 (hydrochloride)

Ropaful

Sobiral

1-(2-(2-Hydroxy-3-(Propylamino)Propoxy)Phenyl)-3

Propatenone Hydrochloride Reference Standard

Propafenone hydrochloride,1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride

Propafenone Hydrochloride (200 mg)

1-Propanone,1-[2-[2-hydroxy-3-(propylaMino)propoxy]phenyl]-3-phenyl-

(±)-Propafenone-d7 HCl

Puluo Pa ketone hydrochloride

1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (1:1)

Rythmol hydrochloride

Rythmol SR hydrochloride

Rytmonorm hydrochloride

Propafenone hydrochloride salt

PropafenoneHydrochloride&gt

Propafenone hydrochloride CRS

Propafenone hydrochL

Propafenone Hydrochloride USP/EP/BP

1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride USP/EP/BP

Propafenone HCl (SA-79)

Propafenone HydrochlorideQ: What is Propafenone Hydrochloride Q: What is the CAS Number of Propafenone Hydrochloride Q: What is the storage condition of Propafenone Hydrochloride Q: What are the applications of Propafenone Hydrochloride

Propafenone Hydrochloride API

Propafenone Hydrochloride (1570304)

34183-22-7

C21H27NO3xHCl

C21H27NO3HCl

C21H28ClNO3

C21H27NO3HClC21H28ClNO3

C21H27NO3ClH

Inhibitors

Amines

Aromatics

Sodium channel

Intermediates & Fine Chemicals

Pharmaceuticals

34183-22-7