Propafenone Hydrochloride
- Product Name
- Propafenone Hydrochloride
- CAS No.
- 34183-22-7
- Chemical Name
- Propafenone Hydrochloride
- Synonyms
- PROPAFENONE HCL;Pronon;Rythmol;rytmonorm;SA-79 (hydrochloride);1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI);sa79;wz884;Ropaful;Sobiral
- CBNumber
- CB1311105
- Molecular Formula
- C21H28ClNO3
- Formula Weight
- 377.9
- MOL File
- 34183-22-7.mol
Propafenone Hydrochloride Property
- Melting point:
- 165-1670C
- storage temp.
- 2-8°C
- solubility
- Slightly soluble in cold water, soluble in methanol and in hot water, practically insoluble in ethanol (96 per cent).
- form
- Solid
- color
- White to Off-White
- λmax
- 303nm(MeOH)(lit.)
- Merck
- 14,7794
- CAS DataBase Reference
- 34183-22-7(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xn
- Risk Statements
- 46-22
- Safety Statements
- 53-36/37/39-45
- WGK Germany
- 3
- RTECS
- UH2833000
- HS Code
- 2922504500
- Toxicity
- LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge)
N-Bromosuccinimide Price
- Product number
- P4670
- Product name
- Propafenone hydrochloride
- Packaging
- 5g
- Price
- $147
- Updated
- 2024/03/01
- Product number
- P-148
- Product name
- Propafenonehydrochloridesolution
- Purity
- 1?mg/mLinmethanol((asfreebase)),certifiedreferencematerial,ampuleof1?
- Packaging
- 1ML
- Price
- $149
- Updated
- 2024/03/01
- Product number
- 1570304
- Product name
- Propafenone hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- P2301
- Product name
- Propafenone Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 21871
- Product name
- Propafenone (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
Propafenone Hydrochloride Chemical Properties,Usage,Production
Description
Propafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.
Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.
Chemical Properties
White Solid
Uses
Propafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.
Uses
Sodium channel blocker. Antiarrhythmic (class IC)
Definition
ChEBI: Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).
brand name
Rythmol (Reliant).
Pharmacokinetics
Propafenone hydrochloride (Rythmol(R)) is similar in action to flecainide. It reduces the fast inward sodium current in Purkinje fibres and to a lesser extent in myocardial fibres. Unlike other class l drugs, propafenone has mild B-blocking effects. This may contribute to its overall effects on the conduction system. lt is also believed to have calcium channel-blocking effects, which may contribute to its mild negative inotropic effects.
Clinical Use
Anti-arrhythmic agent:
Ventricular arrhythmias
Paroxysmal supraventricular tachyarrhythmias,
(including paroxysmal atrial flutter or fibrillation,
and paroxysmal re-entrant tachycardias involving
the AV node or accessory pathway) where standard
therapy has failed or is unsuitable
Drug interactions
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased myocardial depression
with other anti-arrhythmics.
Antibacterials: increased metabolism with rifampicin
(reduced effect).
Anticoagulants: enhanced anticoagulant effect of
coumarins.
Antidepressants: increased risk of arrhythmias
with tricyclics; metabolism of propafenone possibly
inhibited by paroxetine (increased risk of toxicity).
Antihistamines: increased risk of ventricular
arrhythmias with mizolastine - avoid.
Antipsychotics: increased risk of ventricular
arrhythmias with antipsychotics that prolong the QT
interval.
Antivirals: concentration of propafenone increased
by saquinavir and ritonavir and possibly by
fosamprenavir, increased risk of ventricular
arrhythmias - avoid; use with caution with
telaprevir.
Beta-blockers: increased myocardial depression;
increased concentration of metoprolol and
propranolol.
Cardiac glycosides: increased digoxin concentration -
halve digoxin dose.
Ciclosporin: possibly increased ciclosporin
concentration.
Ulcer-healing drugs: levels increased by cimetidine.
Metabolism
Propafenone is hepatically metabolised mainly by
CYP2D6 isoenzyme but also to a small extent by
CYP1A2 and CYP3A4. This forms 2 active metabolites,
5-hydroxypropafenone and N-depropylpropafenone and
some inactive ones. Propafenone and its metabolites also
undergo glucuronidation. The extent of metabolism is
genetically determined.
Propafenone is excreted in the urine and faeces mainly in
the form of conjugated metabolites.
Propafenone Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Propafenone Hydrochloride Suppliers
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View Lastest Price from Propafenone Hydrochloride manufacturers
- Product
- Propafenone HCl 34183-22-7
- Price
- US $180.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-06-05
- Product
- Propafenone 34183-22-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500kg/month
- Release date
- 2021-07-22
- Product
- Propafenone Hydrochloride 34183-22-7
- Price
- US $100.00-1000.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-30