ChemicalBook > CAS DataBase List > Nolatrexed dihydrochloride

Nolatrexed dihydrochloride

Product Name
Nolatrexed dihydrochloride
CAS No.
152946-68-4
Chemical Name
Nolatrexed dihydrochloride
Synonyms
AG 337;CS-254;Thymitaq;NOLATREXED HCL;NOLATREXED 2HCL;Nolatrexed (AG-337);Nolatrexed hydrochloride;Nolatrexed 2hydrochloride;AG337;NOLATREXED (AG 337);NOLATREXED DIHYDROCHLORIDE
CBNumber
CB1313745
Molecular Formula
C14H14Cl2N4OS
Formula Weight
357.26
MOL File
152946-68-4.mol
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Nolatrexed dihydrochloride Property

Melting point:
301-3020C
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Methanol, Water
form 
Solid
pka
4.1; 5.9; 9.8(at 25℃)
color 
Off-White to Pale Yellow
Stability:
Hygroscopic
CAS DataBase Reference
152946-68-4(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29247
Product name
Nolatrexed (hydrochloride)
Packaging
10mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
29247
Product name
Nolatrexed (hydrochloride)
Packaging
100mg
Price
$765
Updated
2024/03/01
Cayman Chemical
Product number
29247
Product name
Nolatrexed (hydrochloride)
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
29247
Product name
Nolatrexed (hydrochloride)
Packaging
50mg
Price
$437
Updated
2024/03/01
Usbiological
Product number
018433
Product name
Nolatrexed Dihydrochloride
Packaging
10mg
Price
$382
Updated
2021/12/16
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Nolatrexed dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

Antifolate thymidylate synthase inhibitor. Antineoplastic.

Biological Activity

thymidylate synthase (ts) is a crucial enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for dna biosynthesis. thus, this enzyme is a critical target in cancer chemotherapy. nolatrexed (ag-337) is a non-classical thymidylate synthase inhibitor.

in vitro

nolatrexed was designed using x-ray crystallographic data from the ts molecular modeling and folate binding site. it is a non-classical ts inhibitor in that it lacks a terminal glutamate side chain and is uncharged at physiological ph. nolatrexed does not require a specific transport mechanism to enter into cells and, once within the cell, is not a substrate for the enzyme folyl polyglutamate synthetase [1].

in vivo

when nolatrexed was administered to nude mice bearing bu25tk- tumor xenografts, a time-dependent increase in antitumor activity was observed [1].

IC 50

1.0, 0.81 and 1.0 μm for l1210, ccrf-cem and gc3/m tk- cell lines, respectively

References

[1] hughes an, rafi i, griffin mj, calvert ah, newell dr, calvete ja, johnston a, clendeninn n, boddy av. phase i studies with the nonclassical antifolate nolatrexed dihydrochloride (ag337, thymitaq) administered orally for 5 days. clin cancer res. 1999 jan;5(1):111-8.
[2] rafi i, boddy av, calvete ja, taylor ga, newell dr, bailey np, lind mj, green m, hines j, johnstone a, clendeninn n, calvert ah. preclinical and phase i clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors. j clin oncol. 1998 mar;16(3):1131-41.

Nolatrexed dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nolatrexed dihydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Nolatrexed dihydrochloride 152946-68-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
Nolatrexed dihydrochloride 152946-68-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kgs
Release date
2020-01-28

152946-68-4, Nolatrexed dihydrochlorideRelated Search:

4-Dimethylaminopyridine Raltitrexed 4-AMINOAZOBENZENE HYDROCHLORIDE 1-AdaMantanethylaMine D-Glucosamine hydrochloride Kresoxim-methyl Methyl salicylate 3-Aminopyridine 4-Aminopyridine Pemetrexed Disodium Nolatrexed Methyl acetate Tribenuron methyl Thiophanate-methyl Pyridine hydrochloride 5-Amino-2-methylpyridine METSULFURON METHYL Pirimiphos-methyl

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