Azido-dPEG4-acid

Product Name: Azido-dPEG4-acid
CAS No.: 1056024-94-2
Chemical Name: Azido-dPEG4-acid
Synonyms: 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoic acid;N3-PEG3-COOH;Azido-dPEG4-acid;N3-PEG3-CH2CH2COOH;Azido-PEG3-CH2CH2COOH;N3-PEG3-COOH,Azido-PEG3-acid;N3-(CH2)2-O-(CH2-CH2-O)2-(CH2)2-COOH;3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoicacid/N3-PEG3-CH2CH2COOH;N3-PEG3-CH2CH2COOH/Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-
CBNumber: CB13146560
Molecular Formula: C9H17N3O5
Formula Weight: 247.25
MOL File: 1056024-94-2.mol

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Azido-dPEG4-acid Property

solubility: DMSO : 100 mg/mL (404.45 mM; Need ultrasonic)
form: Liquid
color: Colorless to light yellow

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Safety

HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A965575
Product name: Azido-peg3Acid
Packaging: 50mg
Price: $155
Updated: 2021/12/16

TRC

Product number: A965575
Product name: Azido-peg3Acid
Packaging: 100mg
Price: $240
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1105
Product name: Azido-PEG3-acid
Packaging: 500mg
Price: $378
Updated: 2021/12/16

BroadPharm

Product number: BP-21583
Product name: Azido-PEG3-acid
Purity: 98%
Packaging: 250mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: AMTGC715
Product name: 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoicacid
Packaging: 250mg
Price: $160
Updated: 2021/12/16

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Azido-dPEG4-acid Chemical Properties,Usage,Production

Description

Azido-PEG3-acid is a crosslinker containing an azide(N3) group with a carboxylic acid (CO2H). The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

Definition

ChEBI: 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid is an organonitrogen compound.

Biological Activity

Azido-dPEG4-acid is a PEG-based PROTAC linker for the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. It is also a non-cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

PEGs	Non-cleavable

Azido-dPEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Azido-dPEG4-acid Suppliers

China 66 India 1 United States 8 Global 75

Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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Xi‘an Deeptech Biotechnology Co.,LTD

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T&W GROUP

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Hunan HuaTeng Pharmaceutical Co., Ltd.,

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Mashilabs (Shanghai) Co.,Ltd.

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Shanghai Macklin Biochemical Co.,Ltd.

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Email: shenlinxing@macklin.cn
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 3984
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View Lastest Price from Azido-dPEG4-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: azido-PEG3-Acid 1056024-94-2
Price: US $0.00/g
Min. Order: 10g
Purity: >98.00%
Supply Ability: 10g
Release date: 2024-03-23

1056024-94-2, Azido-dPEG4-acidRelated Search:

Ethyl acetoacetate Azido-PEG8-t-butyl ester 1-AZIDO-3,6,9-TRIOXAUNDECANE-11-OL Azido-PEG4-NHS Ester N3-PEG4-tBu 1-Azidohexaethylene Glycol 2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL Azido-PEG12-NHS ester Azido-PEG8-NHS ester Azido-PEG2-acid Azide-PEG5-t-butyl ester Azido-PEG2-t-butyl ester Azido-PEG5-NHS ester N3-PEG3-tBu Azido-PEG12-t-butyl ester N3-PEG6-tBu 11-AZIDO-3 6 9-TRIOXAUNDECAN-1-AMINE Azido-PEG3-Sulfone-PEG4-t-butyl ester

Azido-dPEG4-acid

N3-PEG3-CH2CH2COOH

N3-PEG3-COOH,Azido-PEG3-acid

N3-PEG3-COOH

N3-(CH2)2-O-(CH2-CH2-O)2-(CH2)2-COOH

3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoicacid/N3-PEG3-CH2CH2COOH

3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoic acid

N3-PEG3-CH2CH2COOH/Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-

Azido-PEG3-CH2CH2COOH

1056024-94-2

PROTAC Linker

PROTAC

peg