ChemicalBook > CAS DataBase List > 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

Product Name
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
CAS No.
6318-41-8
Chemical Name
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
Synonyms
AS-041164, 10 mM in DMSO;AS-041164, PI3K gamma inhibitor;PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
CBNumber
CB13232856
Molecular Formula
C11H7NO4S
Formula Weight
249.24
MOL File
6318-41-8.mol
More
Less

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Property

Density 
1.595±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
Soluble in DMSO (up to 25 mg/ml).
form 
Yellow solid
pka
7.13±0.20(Predicted)
color 
Yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
528114
Product name
PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem
Packaging
5mg
Price
$238
Updated
2023/01/07
Alfa Aesar
Product number
J67246
Product name
AS-041164
Purity
98%
Packaging
10mg
Price
$123
Updated
2021/12/16
Cayman Chemical
Product number
13622
Product name
AS-041164
Packaging
10mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
13622
Product name
AS-041164
Packaging
50mg
Price
$346
Updated
2024/03/01
Cayman Chemical
Product number
13622
Product name
AS-041164
Packaging
5mg
Price
$72
Updated
2024/03/01
More
Less

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Chemical Properties,Usage,Production

Description

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

References

1) Ferrandi et al. (2007) Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment: J. Pharmacol. Exp. Ther. 322 923

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Suppliers

China 17 Ukraine 1 United States 8 Global 26
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
5944
Advantage
55
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62075
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55013243 15324716602
Email
2853979810@qq.com
Country
China
ProdList
10001
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2615
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5018
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
6828
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9266
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
Tel
13915962545
Email
2881759498@qq.com
Country
China
ProdList
4891
Advantage
58
Tel
Email
sangon@qq.com
Country
CHINA
ProdList
47239
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

6318-41-8, 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-Related Search:

Oxaprozin GSK J1 Amlexanox ROLIPRAM 3-METHYLADENINE WORTMANNIN PI3-Kinase α Inhibitor 2 LY 294002 HYDROCHLORIDE

  • 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
  • PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem
  • Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
  • 5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione
  • AS-041164, PI3K gamma inhibitor
  • AS-041164, 10 mM in DMSO
  • 6318-41-8