2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

Product Name: 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
CAS No.: 6318-41-8
Chemical Name: 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
Synonyms: AS-041164, PI3K gamma inhibitor;PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
CBNumber: CB13232856
Molecular Formula: C11H7NO4S
Formula Weight: 249.24
MOL File: 6318-41-8.mol

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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Property

Density: 1.595±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 25 mg/ml).
form: Yellow solid
pka: 7.13±0.20(Predicted)
color: Yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 528114
Product name: PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem
Packaging: 5mg
Price: $238
Updated: 2023/01/07

Alfa Aesar

Product number: J67246
Product name: AS-041164
Purity: 98%
Packaging: 10mg
Price: $123
Updated: 2021/12/16

Cayman Chemical

Product number: 13622
Product name: AS-041164
Packaging: 10mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 13622
Product name: AS-041164
Packaging: 50mg
Price: $346
Updated: 2024/03/01

Cayman Chemical

Product number: 13622
Product name: AS-041164
Packaging: 5mg
Price: $72
Updated: 2024/03/01

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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Chemical Properties,Usage,Production

Description

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC₅₀ = 70 nM), compared to PI3Kα (IC₅₀ = 240 nM), PI3Kβ (IC₅₀ = 1.45 μM), and PI3Kδ (IC₅₀ =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED₅₀ = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

References

1) Ferrandi et al. (2007) Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment: J. Pharmacol. Exp. Ther. 322 923

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Suppliers

China 15 Ukraine 1 United States 8 Global 24

OTAVA chemicals

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6318-41-8, 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-Related Search:

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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem

Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K

5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione

AS-041164, PI3K gamma inhibitor

6318-41-8