Cholesteryl acetate
- Product Name
- Cholesteryl acetate
- CAS No.
- 604-35-3
- Chemical Name
- Cholesteryl acetate
- Synonyms
- Chol;ACETYL CHOLESTEROL;CHOLESTERYL ACETATE;CHOLESTEROL ACETATE;Chloesteryl acetate;Cholesterin acetate;Cholesterol 3-Acetate;Cholesterol 3β-Acetate;Perampanel Impurity 40;3β-acetoxy-5-cholestene
- CBNumber
- CB1346745
- Molecular Formula
- C29H48O2
- Formula Weight
- 428.69
- MOL File
- 604-35-3.mol
Cholesteryl acetate Property
- Melting point:
- 112-114 °C (lit.)
- alpha
- -44 º (c=2, CHCl3)
- Boiling point:
- 483.49°C (rough estimate)
- Density
- 0.9935 (rough estimate)
- refractive index
- 1.5045 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- insoluble
- form
- Solid
- color
- White to Off-White
- optical activity
- [α]24/D 44°, c = 2 in chloroform
- Water Solubility
- insoluble
- Merck
- 14,2201
- BRN
- 2064235
- Stability:
- Hygroscopic
- LogP
- 10.542 (est)
- CAS DataBase Reference
- 604-35-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Cholesteryl acetate(604-35-3)
- EPA Substance Registry System
- Cholest-5-en-3-ol (3.beta.)-, acetate (604-35-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- TSCA
- Yes
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 151114
- Product name
- Cholesteryl acetate
- Purity
- 97%
- Packaging
- 25g
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 151114
- Product name
- Cholesteryl acetate
- Purity
- 97%
- Packaging
- 100g
- Price
- $328
- Updated
- 2024/03/01
- Product number
- A15052
- Product name
- Cholesteryl acetate, 97+%
- Packaging
- 25g
- Price
- $56
- Updated
- 2023/06/20
- Product number
- A15052
- Product name
- Cholesteryl acetate, 97+%
- Packaging
- 100g
- Price
- $109
- Updated
- 2023/06/20
- Product number
- A15052
- Product name
- Cholesteryl acetate, 97+%
- Packaging
- 500g
- Price
- $458
- Updated
- 2023/06/20
Cholesteryl acetate Chemical Properties,Usage,Production
Chemical Properties
white fine crystalline powder or needles
Uses
Cholesteryl acetate is used in cosmetics, wrist watches, thermometers, propane tank volume indicators, video displays, pharmaceuticals.
Uses
Cholesteryl acetate is derived from cholesterol, which is a major component of all biological membranes. Approximately 25% of total brain lipid is made up of cholesterol, which is the principal sterol of higher animals. Cholesterol is found in all body tissues, with particularly high concentrations in the brain, spinal cord, and animal fats or oils. Additionally, cholesterol is the main constituent of gallstones.
Preparation
Cholesteryl acetate can be synthesized by the reaction of cholesterol with acetic anhydride in the presence of a catalyst such as pyridine or sulfuric acid. The reaction proceeds as follows:
Cholesterol + Acetic anhydride → Cholesteryl acetate + Acetic acid
The reaction is typically carried out at room temperature or slightly elevated temperatures for several hours. The resulting cholesteryl acetate can be purified by recrystallization from a suitable solvent such as ethanol or acetone.
Definition
ChEBI: Cholesteryl acetate is a cholesterol ester obtained by formal acylation of the hydroxy group of cholesterol by acetic acid. It has a role as a human metabolite. It is a cholesteryl ester and an acetate ester.
Reactions
Monophthalic acid epoxidation of cholesteryl acetate:
A solution of 10 g (0.023 mole) of cholesteryl acetate (mp 112-114°) in ether (50 ml) is mixed with a solution containing 8.4 g (0.046 mole) of monophthalic acid (Chap. 17, Sec. II) in 250 ml of ether. The solution is kept at reflux for 6 hours and then the solvent is removed by distillation (steam bath). The residue is dried under vacuum and digested with 250 ml of dry chloroform. The mixture was filtered to give 6.7 g of phthalic acid (87% recovery). The solvent in the filtrate was evaporated under reduced pressure and the residue was crystallised from 30 ml of methanol to give 6.0 g (58% yield) of β-oxocholesterol acetate. Recrystallisation gives the pure product, melting point 111-112°. Concentration of the filtrate gives 1.55 g (15 per cent yield) of α-oxocholesterol acetate with a melting point of 101-103° after crystallisation from ethanol.
Purification Methods
Crystallise the acetate from n-pentanol or Me2CO. Also purify it by chromatography through silica gel and eluting with MeOH. [Beilstein 6 III 2607, 6 IV 4004.]
Cholesteryl acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Cholesteryl acetate Suppliers
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View Lastest Price from Cholesteryl acetate manufacturers
- Product
- Cholesteryl acetate 604-35-3
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-12-05
- Product
- Plant-origin Cholesterol Acetate 604-35-3
- Price
- US $0.00/g
- Min. Order
- 500g
- Purity
- 99%
- Supply Ability
- 10 kg
- Release date
- 2024-08-30
- Product
- Cholesteryl acetate 604-35-3
- Price
- US $0.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2023-06-13