ChemicalBook > CAS DataBase List > 2,2,2-Trichloroethyl chloroformate

2,2,2-Trichloroethyl chloroformate

Product Name
2,2,2-Trichloroethyl chloroformate
CAS No.
17341-93-4
Chemical Name
2,2,2-Trichloroethyl chloroformate
Synonyms
Troc-Cl;2,2,2-trichloroethyl carbonochloridate;Trichloroethyl chloroformate;2,2,2-Trichloroethyl;trichloroethoxycarbonyl chloride;trichloroethylchloroformate;(Trichloroethoxy)chloroformate;2,2,2-TRICHLOROETHYL CHLOROFORMATE;2,2,2 TRI CHLOROETHYL CHLOROFORMAT;2,2,2-trichloroethyl chlorocarbonate
CBNumber
CB1372973
Molecular Formula
C3H2Cl4O2
Formula Weight
211.86
MOL File
17341-93-4.mol
More
Less

2,2,2-Trichloroethyl chloroformate Property

Melting point:
1°C
Boiling point:
171-172 °C (lit.)
Density 
1.539 g/mL at 25 °C (lit.)
vapor pressure 
0.06 psi ( 20 °C)
refractive index 
n20/D 1.471(lit.)
Flash point:
>100°C
storage temp. 
2-8°C
solubility 
soluble in Chloroform, Ethyl Acetate
form 
Liquid
color 
Clear light yellow
Water Solubility 
Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water.
Sensitive 
Moisture Sensitive
BRN 
970619
InChIKey
LJCZNYWLQZZIOS-UHFFFAOYSA-N
CAS DataBase Reference
17341-93-4(CAS DataBase Reference)
NIST Chemistry Reference
Carbonochloridic acid, 2,2,2-trichloroethyl ester(17341-93-4)
EPA Substance Registry System
Carbonochloridic acid, 2,2,2-trichloroethyl ester (17341-93-4)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
23-34-36
Safety Statements 
26-36/37/39-45-7/9
RIDADR 
UN 3277 6.1/PG 2
WGK Germany 
3
F 
10-19
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29159000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
142077
Product name
2,2,2-Trichloroethyl chloroformate
Purity
98%
Packaging
25g
Price
$71.5
Updated
2025/07/31
Sigma-Aldrich
Product number
142077
Product name
2,2,2-Trichloroethyl chloroformate
Purity
98%
Packaging
100g
Price
$192
Updated
2025/07/31
TCI Chemical
Product number
C0795
Product name
2,2,2-Trichloroethyl Chloroformate
Purity
>98.0%(GC)
Packaging
25g
Price
$134
Updated
2025/07/31
TCI Chemical
Product number
C0795
Product name
2,2,2-Trichloroethyl Chloroformate
Purity
>98.0%(GC)
Packaging
250g
Price
$840
Updated
2025/07/31
Sigma-Aldrich
Product number
23258
Product name
2,2,2-Trichloroethyl chloroformate
Purity
purum, ≥98.0% (NT)
Packaging
25ml
Price
$101
Updated
2025/07/31
More
Less

2,2,2-Trichloroethyl chloroformate Chemical Properties,Usage,Production

Chemical Properties

Clear light yellow liquid

Uses

2,2,2-Trichloroethyl chloroformate is used as a protecting reagent for aliphatic and aromatic hydroxyl and amino groups. It is used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples, during N-demethylation of dextromethorphan. It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.

Uses

2,2,2-Trichloroethyl chloroformate was used as:

  • derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples
  • starting reagent during the synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester (IV)
  • reagent during N-demethylation of dextromethorphan
  • protecting group reagent for amines and alcohols

Application

2,2,2-Trichloroethyl chloroformate is a protecting agent for various functional groups; a net carboxylating agent for organometallic reagents; achieves N-demethylation and N-debenzylation of tertiary amines; and activates N-heteroaromatic rings for reaction with organostannanes.

Preparation

2,2,2-Trichloroethyl chloroformate is widely available commercially. It can be readily prepared by passing Phosgene into a solution of 2,2,2- Trichloroethanol in benzene/diethylaniline or benzene/ether/pyridine. An alternate two-step approach (93% yield) has  been described that employs S-Ethyl Chlorothioformate instead of phosgene.

2,2,2-Trichloroethyl chloroformate Preparation Products And Raw materials

Raw materials

Triphosgene tert-Butyl methyl ether Toluene PHOSGENE Ethyl acetate Trichloroethanol Dichloromethane Pyridine Magnesium sulfate heptahydrate

Preparation Products

More
Less

2,2,2-Trichloroethyl chloroformate Suppliers

Americas 1 Belgium 3 China 268 China Hong Kong 1 Czech Republic 1 Europe 4 France 4 Germany 6 India 22 Japan 6 Slovakia 1 South Korea 2 Spain 1 Switzerland 1 The Netherlands 1 United Kingdom 11 United States 37 Global 370
Suzhou Highfine Biotech Co., Ltd
Tel
0512-69209928 18796809688
Email
zhouyingxiang@highfine.com
Country
China
ProdList
1356
Advantage
58
Shanghai Kangtuo Chemical Co., Ltd.
Tel
021-69185552 13701777608
Fax
021-69186006
Email
kangtuochem@163.com
Country
China
ProdList
4232
Advantage
55
Jiaxing Deyi Chemical Co., Ltd
Tel
0573-85866609 13588473046
Email
824930988@qq.com
Country
China
ProdList
7865
Advantage
58
Hubei Hongfuda Biotechnology Co., Ltd.
Tel
180-86404407 17340521416
Email
1757224788@qq.com
Country
China
ProdList
717
Advantage
58
XINYI YONGCHENG CHEMICAL INDUSTRIAL CO.,LTD.
Tel
152-5149-9520 15952286050
Email
Melodyhl886@163.com
Country
China
ProdList
107
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9309
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3199
Advantage
55
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
Shanghai GaoLang Chemical Technology Co., Ltd.
Tel
021-57340939 18017297327
Fax
021-37210791
Email
sales@gaolangchemical.com
Country
China
ProdList
892
Advantage
55
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3027
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
GuangTuo Chemical (Shanghai) Co., Ltd.
Tel
021-60899189-8001 18918189673
Fax
021-60899304
Email
gtchem@126.com
Country
China
ProdList
2656
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
More
Less

View Lastest Price from 2,2,2-Trichloroethyl chloroformate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,2,2-Trichloroethyl chloroformate 17341-93-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19
Henan Fengda Chemical Co., Ltd
Product
2,2,2-Trichloroethyl chloroformate 17341-93-4
Price
US $8.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,2,2-Trichloroethyl chloroformate 17341-93-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

17341-93-4, 2,2,2-Trichloroethyl chloroformateRelated Search:

Ethyl formate Trichlorosilane 2-Chloroethyl chloroformate Sucralose Urethane 1-Chloroethyl chloroformate Triethyl orthoformate Diethyl azodicarboxylate Tris(2-chloroethyl) phosphate Trichloroethylene Ethyl cyanoformate Ethyl maltol Hydroxyethyl Cellulose Diethyl phthalate Ethyl chloroformate Chloroform 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE 1,1,1-Trichloroethane

  • 2,2,2-trichloroethyl carbonochloridate
  • 2,2,2-Trichloroethyl chloroforMate puruM, >=98.0% (NT)
  • NALPHA-tert-Butoxycarbonyl-NEPSILON-trifluoroacetyl-D -lysine
  • (Trichloroethoxy)chloroformate
  • 2,2,2-Trichloroethyl chloroformate ,97%
  • (2,2,2-Trichloroethoxy)formic acid chloride
  • (Carbonic acid 2,2,2-trichloroethyl) chloride
  • Chloridocarbonic acid 2,2,2-trichloroethyl ester
  • Chloroformic acid 2,2,2-trichloroethyl
  • 2,2,2-trichloroethyl chlorocarbonate
  • 2,2,2-Trichloroethyl chloroformate,96%
  • Troc-Cl trichloroethoxycarbonylchloride
  • trichloroethoxycarbonyl chloride
  • Troc-Cl
  • 2,2,2-Trichloroethyl chloroformate,2,2,2-Trichloroethoxycarbonyl chloride
  • Chloroformic Acid 2,2,2-Trichloroethyl Ester,95%
  • 2,2,2-Trichloroethyl
  • 2,2,2-Trichloroethyl chloroforMate, 96% 100GR
  • 2,2,2-Trichloroethyl chloroforMate, 96% 25GR
  • 2,2,2-Trichloroethyl carbonochloridoate
  • BETA,BETA,BETA-TRICHLOROETHOXYCARBONYL CHLORIDE
  • CHLOROFORMIC ACID 2,2,2-TRICHLOROETHYL ESTER
  • 2,2,2-TRICHLOROETHYL CHLOROFORMATE
  • 2,2,2-TRICHLORO-ETHOXYCARBONYL CHLORIDE
  • 2,2,2-Trichloroethyl chloridocarbonate
  • carbonochloridicacid,2,2,2-trichloroethylester
  • Formic acid, chloro-, 2,2,2-trichloroethyl ester
  • Trichloroethyl chloroformate
  • trichloroethylchloroformate
  • Chloroformic acid 2,2,2-trichloroethyl ester~2,2,2-Trichloroethoxycarbonyl chloride~TrocCl
  • 2,2,2 TRI CHLOROETHYL CHLOROFORMAT
  • 2,2,2-Trichloroethylchloroformate99%
  • 2,2,2-trichloroethylchloranuidylformate
  • Trichloroethoxycarbonyl chloride(Troc-CL)
  • 2,2,2-Trichloroethyl Chloroformate &gt
  • Troc-CL trichloroethoxycarbonyl chloride ,97%
  • 2,2,2-Trichlorethoxycarbonyl chloride
  • 2,2,2-Trichloroethyl chloroformate17341-93-4
  • 2,2,2-TRICHLOROETHYL CHLOROFORMATE Extra Pure
  • 2,2,2-Trichloroethyl chloroformate (2,2,2-TCECF)
  • β-D-Fructopyranose,1,2:4,5-bis-O-(1-methylethylidene)-,sulfamate(9CI)
  • 17341-93-4
  • 1734-19-3
  • ClCO2CH2CCl3
  • ClCOOCH2CCl3
  • C3H2Cl4O2
  • Protection & Derivatization Reagents (for Synthesis)
  • Acid Halides
  • Organic Building Blocks
  • Carbonyl Compounds
  • Building Blocks
  • Acid Halides
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Miscellaneous
  • Protection & Derivatization Reagents (for Synthesis)