Fmoc-L-tert-leucine

Product Name: Fmoc-L-tert-leucine
CAS No.: 132684-60-7
Chemical Name: Fmoc-L-tert-leucine
Synonyms: FMOC-TLE-OH;(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3,3-diMethylbutanoic acid;FMOC-TBU-GLY-OH;FMOC-L-TLE-OH;FMOC-TBU-GLYCINE;FMOC-L-T-LEUCINE;RARECHEM EM WB 0083;FMOC-L-TERT-LEUCINE;FMOC-L-T-BUTYLGLYCINE;N-Fmoc-L-tert-leucine
CBNumber: CB1386464
Molecular Formula: C21H23NO4
Formula Weight: 353.41
MOL File: 132684-60-7.mol

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Fmoc-L-tert-leucine Property

Melting point:: 124-127 °C
Boiling point:: 554.1±33.0 °C(Predicted)
Density: 1.209±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ≥ 35.3mg/mL in DMSO, ≥ 49.6 mg/mL in EtOH
pka: 3.92±0.10(Predicted)
form: powder to crystal
color: White to Light yellow
BRN: 6662856
CAS DataBase Reference: 132684-60-7(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52027
Product name: Fmoc-α-t-butylglycine
Purity: Novabiochem?
Packaging: 1g
Price: $181
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52027
Product name: Fmoc-α-t-butylglycine
Purity: Novabiochem?
Packaging: 5G
Price: $713
Updated: 2025/07/31

Sigma-Aldrich

Product number: 47524
Product name: Fmoc-tBu-Gly-OH
Purity: ≥98.0%
Packaging: 1g
Price: $306
Updated: 2025/07/31

TCI Chemical

Product number: F1251
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine
Packaging: 5G
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: F1251
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine
Packaging: 25G
Price: $212
Updated: 2025/07/31

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Fmoc-L-tert-leucine Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Fmoc-Tle-OH is a versatile reactant used in the discovery of potent antagonists of antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) for treatment of cancer. It is also used as reactant in the preparation of phosphino dipeptide derivatices as ligand in copper-phosphine catalyst for asymmetric conjugate addition of alkylzinc reagents to unsaturated ketones.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

20859-02-3

28920-43-6

132684-60-7

General procedure for the synthesis of Fmoc-L-tert-leucine from L-tert-leucine and 9-fluorenylmethyl chloroformate: a 500 mL reaction flask was taken and to it was added L-tert-leucine (5.1 g, 38.6 mmol), dioxane (40 mL), and 10% sodium carbonate solution (100 mL). The reaction flask was placed in an ice bath and a dioxane solution (100 mL) of methyl chloroformate-9-fluorenyl (10.0 g, 38.6 mmol) was slowly added through a dropping funnel under mechanical stirring. After dropwise addition, the solution was gradually returned to room temperature and stirring was continued overnight. After completion of the reaction, 100 mL of water was added and extracted three times with 50 mL of ether, retaining the aqueous phase. The aqueous phase was cooled in an ice bath and the pH was adjusted slowly to 1 by adding 1 M dilute hydrochloric acid. subsequently, the aqueous solution was extracted three times with 50 mL of ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to dryness to give the intermediate Fmoc-L-tert-leucine (14.3 g, 96% yield).

References

[1] Patent: CN106588987, 2017, A. Location in patent: Paragraph 0195; 0196; 0197
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 45, p. 11846 - 11851
[3] Angew. Chem., 2013, vol. 125, # 45, p. 12062 - 12067,6
[4] Chemistry - A European Journal, 2014, vol. 20, # 21, p. 6526 - 6531
[5] Patent: WO2018/145021, 2018, A1. Location in patent: Page/Page column 134

Fmoc-L-tert-leucine Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-L-tert-leucine Suppliers

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View Lastest Price from Fmoc-L-tert-leucine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-Tle-OH 132684-60-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-29

Career Henan Chemical Co

Product: Fmoc-L-tert-leucine 132684-60-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-03

132684-60-7, Fmoc-L-tert-leucineRelated Search:

N-CARBOBENZOXY-DL-LEUCINE Glycine Nalpha-Fmoc-Ndelta-trityl-L-glutamine tert-Butyl peroxyacetate Fmoc-Phe-OH 9-Fluorenylmethyl chloroformate METHOXYCARBONYLSULFENYL CHLORIDE Fmoc-Lys(Boc)-OH L-Fmoc-Aspartic acid alpha-tert-butyl ester tert-Butanol 6-Aminocaproic acid FMOC-L-Valine tert-Butyl acetate Fmoc-Asp(OtBu)-OH L-tert-Leucine Fmoc-OSu DL-Leucine FMOC-N-Methyl-L-alanine

(S)-N-FMOC-2-AMINO-3,3-DIMETHYL BUTANOIC ACID

RARECHEM EM WB 0083

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-TERT-BUTYL-GLYCINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-T-LEUCINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-(S)-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID

FMOC-L-TLE-OH

FMOC-L-T-BUTYLGLYCINE

FMOC-L-TERT-LEUCINE

FMOC-TLE-OH

FMOC-TBU-GLYCINE

FMOC-TBU-GLY-OH

FMOC-ALPHA-T-BUTYL-GLY-OH

FMOC-ALPHA-T-BUTYLGLYCINE

FMOC-L-ALPHA-T-BUTYLGLYCINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ALPHA-T-BUTYLGLYCINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-TERT-LEUCINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-T-LEUCINE

N-ALPHA-FMOC-L-T-BUTYLGLYCINE

N-ALPHA-FMOC-L-T-LEUCINE

N-ALPHA-FMOC-L-ALPHA-T-BUTYL-GLYCINE

N-ALPHA-T-FMOC-L-ALPHA-T-BUTYL-GLYCINE

N-ALPHA-T-FMOC-L-T-LEUCINE

N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-t-leucine, N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-t-butyl-glycine

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)-3,3-dim

(S)-N-Fmoc-2-amino-3,3-dimethyl-butyric acid

N-9-Fluorenylmethoxycarbonyl-L-tert-leucine

Fmoc-L-tert-leucine, Fmoc-Tle-OH

FMoc-Tle-OH (FMoc-tertleucine)

(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3,3-diMethylbutanoic acid

FMOC-L-T-LEUCINE

Fmoc-L-α-tert-butylglycine

Fmoc-L-α-tert-butylglycine≥ 99% (HPLC)

(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3-dimethylbutanoic acid

Fmoc-tBu-Gly-OH, ≥98.0%

Fmoc-L-α-tert-butyl-Gly-OH

Fmoc-α-t-butylglycine Novabiochem

(9H-Fluoren-9-yl)MethOxy]Carbonyl Tle-OH

L-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-methyl-

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine

(S)-2-(Fmoc-amino)-3,3-dimethylbutyric Acid

N-Fmoc-L-tert-leucine

Fmoc-L-tert-leucine USP/EP/BP

Fmoc-L-alpha-t-butylglycine - 1 g

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-valine

132684-60-7

Leucine Derivatives

Peptide Synthesis

Unnatural Amino Acid Derivatives

Specialty Synthesis

Amino Acids & Deriv.

CHIRAL CHEMICALS

Peptide

API intermediates

Amino Acids