6-CHLORO-7-METHYLPURINE

Product Name: 6-CHLORO-7-METHYLPURINE
CAS No.: 5440-17-5
Chemical Name: 6-CHLORO-7-METHYLPURINE
Synonyms: NSC 15192;7-METHYL-6-CHLOROPURINE;6-CHLORO-7-METHYLPURINE;6-Chloro-7-methyl-7H-purine;7H-Purine, 6-chloro-7-methyl-
CBNumber: CB1429820
Molecular Formula: C6H5ClN4
Formula Weight: 168.58
MOL File: 5440-17-5.mol

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6-CHLORO-7-METHYLPURINE Property

Melting point:: 175-185°C
Boiling point:: 321.7±45.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)
form: Solid
pka: 0.65±0.30(Predicted)
color: Light Green to Grey-Blue
CAS DataBase Reference: 5440-17-5

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C369495
Product name: 6-Chloro-7-methylpurine
Packaging: 50mg
Price: $120
Updated: 2021/12/16

Usbiological

Product number: C5028-60
Product name: 6-Chloro-7-methylpurine
Packaging: 25mg
Price: $389
Updated: 2021/12/16

TRC

Product number: C369495
Product name: 6-Chloro-7-methylpurine
Packaging: 500mg
Price: $645
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC09543
Product name: 6-Chloro-7-methylpurine
Packaging: 10mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC09543
Product name: 6-Chloro-7-methylpurine
Packaging: 25mg
Price: $100
Updated: 2021/12/16

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6-CHLORO-7-METHYLPURINE Chemical Properties,Usage,Production

Chemical Properties

Light Green Solid

Uses

6-CHLORO-7-METHYLPURINE is a useful synthetic intermediate.

Synthesis

87-42-3

74-88-4

5440-17-5

To a 1L three-necked round-bottomed flask was added 6-chloro-9H-purine (15.4 g, 0.1 mol, 1 eq.) and tetrahydrofuran (155 mL) at 0 °C and protected by nitrogen in an inert atmosphere. Methylmagnesium chloride (MeMgCl, 36.6 mL, 1.0 M THF solution, 1.1 eq.) was added dropwise with stirring. The reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, iodomethane (42.6 g, 3 eq.) was added slowly and dropwise with stirring. The resulting reaction solution was transferred to a 50 °C oil bath and the reaction was stirred for 5 hours. Upon completion of the reaction, the reaction was quenched by addition of 50 mL of aqueous ammonium chloride (NH4Cl) and extracted with dichloromethane (3 x 50 mL). The organic layers were combined and washed with brine (2 x 50 mL) and subsequently concentrated under vacuum. The crude product was recrystallized by dichloromethane/petroleum ether (1:10) to afford 6-chloro-7-methylpurine as a light green solid (7 g, 42% yield).

References

[1] Organic Letters, 2016, vol. 18, # 1, p. 16 - 19
[2] Patent: WO2018/96159, 2018, A1. Location in patent: Paragraph 0169-0172

6-CHLORO-7-METHYLPURINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-7-METHYLPURINE Suppliers

Canada 1 China 53 Germany 1 India 1 United Kingdom 4 United States 4 Global 64

Aladdin Scientific

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Country: United States
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SynQuest Laboratories, Inc.

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Matrix Scientific

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Medical Isotopes

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Country: United States
ProdList: 6181
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View Lastest Price from 6-CHLORO-7-METHYLPURINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-CHLORO-7-METHYLPURINE 5440-17-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-CHLORO-7-METHYLPURINE 5440-17-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 6-CHLORO-7-METHYLPURINE 5440-17-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99.99%
Supply Ability: 1kg-10MT
Release date: 2019-05-24

5440-17-5, 6-CHLORO-7-METHYLPURINERelated Search:

6-chloro-5-Methylpyridazin-3-aMine 6-Chloro-4-methylpyridazin-3-amine 6-Chloropurine 2-METHYLTHIO-6-CHLORO-9-METHYLPURINE 97% (HPLC) 6-CHLORO-9-METHYLPURINE 6-AMINO-2-CHLORO-7-METHYLPURINE 2-AMINO-6-CHLORO-7-ISOPROPYLPURINE 6-CHLORO-7-METHYLPURINE 6-CHLORO-2,8-DIMETHYL-7-(PHENYLMETHYL)-7H-PURINE 2-AMINO-6-CHLORO-7-(2,3-DIDEOXY-3-FLUORO-5-O(4-PHENYLBENZOYL)-BETA-D-ERYTHROPENTOFURANOSYL)-7H-PURINE 6-CHLORO-7-BENZYLPURINE 2,6,8-TRICHLORO-7-METHYLPURINE 4-CHLORO-7,8-DIHYDRO-6H-PYRROLO[2,1-F]PURINE 2,6-Dichloro-7-methylpurine 4-CHLORO-6,7,8,9-TETRAHYDROPYRIDO[2,1-F]PURINE

6-CHLORO-7-METHYLPURINE

7-METHYL-6-CHLOROPURINE

NSC 15192

6-Chloro-7-methyl-7H-purine

7H-Purine, 6-chloro-7-methyl-

5440-17-5

Bases & Related Reagents

Nucleotides