ChemicalBook > CAS DataBase List > 2-Cyanopyrimidine

2-Cyanopyrimidine

Product Name
2-Cyanopyrimidine
CAS No.
14080-23-0
Chemical Name
2-Cyanopyrimidine
Synonyms
PYRIMIDINE-2-CARBONITRILE;2-PYRIMIDINECARBONITRILE;2CPM;2-CPY;2-cyanpyrimidine;2-Cynopyrimidine;2-CYANOPYRIMIDINE;Bosentan Impurity 14;Bosentan Impurity 15;2-Cyanopyrimidine >
CBNumber
CB1431357
Molecular Formula
C5H3N3
Formula Weight
105.1
MOL File
14080-23-0.mol
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2-Cyanopyrimidine Property

Melting point:
40-44 °C (lit.)
Boiling point:
250.7±23.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
-3.27±0.13(Predicted)
form 
Crystalline Powder
color 
White to yellow
InChIKey
IIHQNAXFIODVDU-UHFFFAOYSA-N
CAS DataBase Reference
14080-23-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,C,F,T
Risk Statements 
22-37/38-41-43-34-11-25
Safety Statements 
26-36/37/39-45-16-36/37
RIDADR 
3276
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
646830
Product name
2-Pyrimidinecarbonitrile
Purity
97%
Packaging
5g
Price
$37.8
Updated
2024/03/01
Sigma-Aldrich
Product number
646830
Product name
2-Pyrimidinecarbonitrile
Purity
97%
Packaging
25g
Price
$50
Updated
2024/03/01
TCI Chemical
Product number
C1518
Product name
2-Cyanopyrimidine
Purity
>98.0%(GC)
Packaging
1g
Price
$24
Updated
2024/03/01
TCI Chemical
Product number
C1518
Product name
2-Cyanopyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
10007121
Product name
2-cyano-Pyrimidine
Purity
>98%
Packaging
500mg
Price
$11
Updated
2024/03/01
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2-Cyanopyrimidine Chemical Properties,Usage,Production

Chemical Properties

White to yellow to brown solid

Biological Activity

2-cyano-pyrimidine is a cathepsin k inhibitor.cathepsin k is a protease defined by its high specificity for kinins, which is involved in bone resorption. cathepsin k's ability to catabolize collagen, elastin, and gelatin allow it to break down bone and cartilage. such catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. therefore, inhibitors of cathepsin k are showing great potential in the treatment of osteoporosis.

in vitro

2-cyano-pyrimidine was identified as a cathepsin k inhibitor whose basic structure and derivatives have been evaluated for the treatment of osteoporosis. enzymatic study showed that 2-cyano-pyrimidine had an ic50 value of 170 nm for inhibition of cathepsin k, elevated activity of which has been linked to the formation of osteoporosis and arthritis. moreover, cathepsin k was found to be a lysosomal cysteine protease found in osteoclasts. [1,2].

IC 50

170 nm

References

[1] altmann, e. ,aichholz, r.,betschart, c., et al. 2-cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin k. journal of medicinal chemistry 50(4), 591-594 (2007).
[2] rankovic z et al. design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin k inhibitors. bioorg med chem lett. 2010 mar 1;20(5):1524-7.

2-Cyanopyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Cyanopyrimidine Suppliers

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View Lastest Price from 2-Cyanopyrimidine manufacturers

Shanghai UCHEM Inc.
Product
2-Cyanopyrimidine 14080-23-0
Price
US $20.00-179.00/g
Min. Order
1g
Purity
0.99
Supply Ability
10kg
Release date
2024-04-12
Hebei Weibang Biotechnology Co., Ltd
Product
2-Cyanopyrimidine 14080-23-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2021-11-09
Hangzhou ICH Biofarm Co., Ltd
Product
2-Cyanopyrimidine 14080-23-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99.0% min
Supply Ability
10tons/month
Release date
2023-06-13

14080-23-0, 2-CyanopyrimidineRelated Search:

ETHYL 2-CYANOACRYLATE Cyanoacetic acid Ethyl cyanoacetate Ethyl cyanoformate Methylene dithiocyanate Sodium cyanoborohydride 3-Cyanopyridine 2-Methylsulfonyl-4,6-dimethoxypyrimidine 2-Chloropyrimidine 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione 2-(2-Methoxyphenoxy)propanedioic acid diethyl ester Bosentan Bosentan Impurity 1 Diethyl chloromalonate Bosentan Impurity 5 Bosentan Impurity 17 Bosentan Impurity 7 Bosentan Impurity 2

  • 2CPM
  • 2-CPY
  • 2-CYANOPYRIMIDINE
  • 2-PYRIMIDINECARBONITRILE
  • PYRIMIDINE-2-CARBONITRILE
  • 2-Cynopyrimidine
  • 2-cyanpyrimidine
  • 2-Pyrimidinecarbonitrile (6CI,7CI,8CI,9CI)
  • Pyrimidine-2-carbonitrile 98%
  • 2-CYANOPYRIMIDINE, 98+%
  • PYRIMIDINE-2-CARBONITRILE (2-CYANOPYRIMIDINE)
  • NaMe: 2-CyanopyriMidine
  • 2-Cyanopyrimidine ,99%
  • 2-Cyanopyrimidine, 2-Cyano-1,3-diazine
  • 2-PyriMidinecarbonitrile 97%
  • 2-Cyanopyrimidine (2-Pyrimidine Carbonitrile)
  • 2-Cyanopyrimidine &gt
  • Bosentan Impurity 14
  • 2-Cyanopyrimidine ISO 9001：2015 REACH
  • Bosentan Impurity 15
  • Benzene,1-ethenyl-7-nitro-
  • 14080-23-0
  • 4080-23-0
  • 1408-23-0
  • C5H3N3
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Building Blocks
  • Heterocycle-Pyrimidine series
  • cyanide
  • Building Blocks
  • C4 to C5
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrazines, Pyrimidines & Pyridazines
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines
  • APIs & Intermediate
  • Pyridines, Pyrimidines, Purines and Pteredines
  • PYRIMIDINE
  • FINE Chemical & INTERMEDIATES
  • bc0001