GLP-1 (7-37)
- Product Name
- GLP-1 (7-37)
- CAS No.
- 106612-94-6
- Chemical Name
- GLP-1 (7-37)
- Synonyms
- Tglp-1;GLP-1, 7-37;HuMan GLP-1;Glp-I (7-37);insulinotropin;GLP-1(7-37), >98%;Human GLP-1 (7-37);GLP-1 acetate salt;GLP-1 (7-37) (HUMAN);GLP-1(7-37) impurity
- CBNumber
- CB1445727
- Molecular Formula
- C151H228N40O47
- Formula Weight
- 3355.67
- MOL File
- 106612-94-6.mol
GLP-1 (7-37) Property
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Water:30.0(Max Conc. mg/mL);8.34(Max Conc. mM)
- form
- Lyophilized powder
- Water Solubility
- Soluble in water at 2mg/ml
- Sequence
- H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH
- CAS DataBase Reference
- 106612-94-6
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- G9416
- Product name
- Glucagon-Like Peptide 1 Fragment 7-37 human
- Purity
- ≥96% (HPLC)
- Packaging
- 0.5mg
- Price
- $530
- Updated
- 2024/03/01
- Product number
- J66232
- Product name
- Glucagon Like Peptide-1 (7-37)
- Packaging
- 0.5mg
- Price
- $191
- Updated
- 2023/06/20
- Product number
- J66232
- Product name
- Glucagon Like Peptide-1 (7-37)
- Packaging
- 1mg
- Price
- $364
- Updated
- 2023/06/20
- Product number
- 5374
- Product name
- GLP-1(7-37)
- Packaging
- 1
- Price
- $458
- Updated
- 2021/12/16
- Product number
- CS-5975
- Product name
- GLP-1(7-37)
- Purity
- 99.87%
- Packaging
- 5mg
- Price
- $432
- Updated
- 2021/12/16
GLP-1 (7-37) Chemical Properties,Usage,Production
Description
GLP-1 (7-37) is an endogenous truncated form of GLP-1 that arises from proglucagon processing in intestinal endocrine L cells, GLP-1 (7-37) acts as a GLP-1 receptor agonist and is an insulinotropic hormone that augments glucose induced insulin secretion. GLP-1 (7-37) and derivatives GLP-1 (9-37) and GLP-1 (28-37) can reduce plaque inflammation and increase phenotypic characteristics of plaque stability in a murine model of atherosclerosis.
Uses
Glucagon-Like Peptide 1 Fragment 7-37 human has been used:
- as a positive control for insulin secretion of pancreatic islets
- to test its effect on insulin response in horse islets
- in combination with mesenchymal stem cells (MSCs) test its protective effects in myocardial infarction
General Description
Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)) is an amino-truncated form of GLP-1.
Biochem/physiol Actions
Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)) interacts with the GLP-1 receptor (GLP-1r). It mediates insulin release by stimulating the cyclic AMP accumulation in islet cells GLP-l(7-37) is a potential therapeutic agent due to its insulin-secretagogue functionality.
in vitro
In vitro, truncated glucagon-like peptides [GLP-1(7-36)-amide and GLP-1(7-37)] increase insulin secretion in a glucose-dependent manner, and desensitization to the action of GLP-1(7-37) has been demonstrated acutely with high concentrations.
in vivo
GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats. Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM.
storage
Store at -20°C
GLP-1 (7-37) Preparation Products And Raw materials
Raw materials
Preparation Products
GLP-1 (7-37) Suppliers
View Lastest Price from GLP-1 (7-37) manufacturers
- Product
- GLP-1 (7-37) 106612-94-6
- Price
- US $28.00/box
- Min. Order
- 1box
- Purity
- 99%
- Supply Ability
- 20000
- Release date
- 2024-04-11
- Product
- GLP-1 (7-37) 106612-94-6
- Price
- US $80.00-800.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-02
- Product
- GLP-1 (7-37) 106612-94-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-10-30