ChemicalBook > CAS DataBase List > Omalizumab

Omalizumab

Product Name: Omalizumab
CAS No.: 242138-07-4
Chemical Name: Omalizumab
Synonyms: Xolair;OMALIZUMAB;Omalizumab 75.4mg/ml;Omalizumab (anti-IgE);Research Grade Omalizumab;Omalizumab - buffer solution;Research Grade Omalizumab(DHJ92701);humanized,asthma,IgE,CD40,allergic,IL-4,IL-6,FcγRIIb,Olizumab,Inhibitor,immunoglobulin,FcεRI,rhuMab-E25,Omalizumab,inhibit;Immunoglobulin G1,anti-(human immunoglobulin E Fc region) (human-mouse monoclonal E25 clonepSVIE25 g-chain), disulfide withhuman-mouse monoclonal E25 clone pSVIE25 k-chain, dimer (9CI)
CBNumber: CB1466472
Formula Weight: 0
MOL File: Mol file

Less

Omalizumab Property

form: Solid
color: White to light yellow

Less

Safety

Hazardous Substances Data: 242138-07-4(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Usbiological

Product number: 384864
Product name: Omalizumab
Packaging: 96Tests
Price: $1114
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO139134
Product name: Omalizumab - buffer solution
Packaging: 2mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO139134
Product name: Omalizumab - buffer solution
Packaging: 5mg
Price: $500
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO139134
Product name: Omalizumab - buffer solution
Packaging: 10mg
Price: $700
Updated: 2021/12/16

DC Chemicals

Product number: 013348
Product name: Omalizumab
Packaging: 003
Price: $1800
Updated: 2021/12/16

Less

Omalizumab Chemical Properties,Usage,Production

Description

Omalizumab is a recombinant humanized construct of murine IgG1k monoclonal antibody introduced for the treatment of allergic asthma. It forms complexes with free, circulating serum IgE, which results in the inhibition of binding of IgE to the high-affinity IgE-receptor (FCeRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Omalizumab is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin. The recommended dosage is 150–375 mg administered subcutaneously every 2 or 4 weeks. Omalizumab has an average absolute bioavailability of 62% and an average terminal half-life of 26 days. Following a single SC dose, omalizumab is absorbed slowly, reaching peak serum concentrations after 7–8 days. However, serum levels of free IgE begin to decline in a dosedependent manner within an hour after the first injection and typically lead to ＞96% reduction in free IgE concentrations. The omalizumab-IgE complexes have a longer half-life and are eliminated more slowly than free IgE. After 16 weeks of dosing, total serum IgE (free plus bound IgE) is five times higher than pretreatment levels. Clearance of the omalizumab-IgE complexes occurs via the Fcg receptors reticuloendothelial system. The efficacy and safety of omalizumab in the treatment of inhaled corticosteroid-dependent (ICS) asthma was evaluated in a 28-week doubleblinded, placebo-controlled clinical study, which entailed co-administration of ICS for 16 weeks, followed by a gradual reduction in ICS dose over 12 weeks. A significant reduction in steroid dose with fewer exacerbations during steroid withdrawal phase was noted and more subjects receiving omalizumab were able to discontinue their ICS than in the placebo group (39.6 vs 19.1%, respectively; p ＜0.001). Omalizumab was well tolerated and the most common adverse effects were arthralgia, generalized pain, leg pain, and injection-site reactions.

Originator

Genentech (US)

Uses

Treatment of atopic disease (asthma; rhinitis) (monoclonal antibody).

brand name

Xolair (Genentech).

Mechanism of action

Additional amino acid sequences have been incorporated into the antibody so that a humanized product resulted that only differs by 5% nonhuman amino acid residues. In vitro, omalizumab has been shown to complex with free IgE, forming trimers consisting of a 2:1 complex of IgE to omalizumab or a 1:2 complex of IgE to omalizumab. In addition, larger complexes also are formed, consisting of a 3:3 ratio of each. Omalizumab does not bind to IgE already bound to mast cells and, therefore, does not cause the degranulation that might be expected from such interaction. Thus, omalizumab effectively neutralizes free IgE and, aside from the obvious decrease of available IgE, also causes the down-regulation of FcεRI receptors on the mast cell surface, resulting in a decrease of IgE bound to the mast cell.

Pharmacokinetics

The bioavailability after subcutaneous administration is 62%, with slow absorption resulting in peak serum levels in 7 to 8 days from a single dose. Steady-state plasma concentration is reached in 14 to 29 days with multiple dosing regimens. The elimination of omalizumab is not clearly understood; however, studies have determined that intact IgE is excreted via the bile and that omalizumab:IgE complexes are cleared faster than uncomplexed omalizumab and slower than free IgE. This means that over time, total IgE concentrations (free and complexed IgE) increase, because the complex is cleared more slowly. The metabolism of omalizumab is not known, and the clearance of the complex is similar to the liver elimination of another immunoglobulin, IgG. The reticuloendothelial system degrades IgG, and it is believed that the same process occurs for the omalizumab:IgE complex.

Clinical Use

The clinical role for omalizumab is in the treatment of allergic asthma. It is approved for the treatment of adults and adolescents 12 years of age and older whose symptoms are not controlled with inhaled glucocorticoids and who have a positive skin test for airborne allergens.

Omalizumab Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Omalizumab Suppliers

China 84 Europe 2 India 1 South Korea 1 United Kingdom 1 United States 6 Global 95

Wuhan Sunrise Technology Development Co., Ltd.

Tel: 27-027-83314682 13554138826
Fax: +86 (27) 8331-4682
Email: whsrtech@vip.163.com
Country: China
ProdList: 246
Advantage: 62

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2744
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

LUCKY PHARMA CO., LIMITED

Tel: 0571-86403260 86403970
Fax: 0571-86403970
Email: lucky@lkbiology.com
Country: China
ProdList: 243
Advantage: 58

Taizhou KEDE Chemical Co., Ltd

Tel: 0576-84613060 13093829633
Fax: 0576-84613060
Email: sales@kedechemical.com
Country: China
ProdList: 299
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

Shanghai Hanjing Chemicals Co., Ltd.

Tel: 021-54285032 13641685631
Fax: +86 (21) 5443 7651
Email: gerry.shu@hanjingchemicals.com
Country: China
ProdList: 76
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd.

Tel: +86-0551-62678551 +86-15056975894
Fax: 05512678551
Email: sales@hirisunpharm.com
Country: China
ProdList: 176
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3931
Advantage: 58

Chemleader Biomedical Co., Limited.

Tel: 021-58180488
Fax: 021-58180499
Email: sales@MedChemLeader.com
Country: China
ProdList: 1006
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10237
Advantage: 58

Hangzhou Huarong Pharm Co., Ltd.

Tel: 571-86758373 +8613588754946
Fax: 0086-571-81131109
Email: sales@huarongpharm.com
Country: CHINA
ProdList: 3148
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

Baoji Guokang Healthchem co.,ltd

Tel: +8615604608665 15604608665
Email: dominicguo@gk-bio.com
Country: CHINA
ProdList: 9414
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

HONG KONG IPURE BIOLOGY CO.,LIMITED

Tel: 86 18062405514 18062405514
Email: ada@ipurechemical.com
Country: CHINA
ProdList: 3461
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: doncunbiosci@gmail.com
Country: China
ProdList: 544
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

Wuhan Dingtong Pharmaceutical Co., Ltd

Tel: 027-027-59207795 18327179646
Fax: 027-59207795
Email: 18327179646@163.com
Country: China
ProdList: 1986
Advantage: 58

Guangzhou Hongyuan Chemical Co.,Ltd

Tel: 15817493340
Email: 981810490@qq.com
Country: China
ProdList: 1566
Advantage: 58

Jiangsu Greature Bio-Medicine Co., Ltd.

Tel: 0512-85557988 18662338937
Fax: 0512-85557182
Email: frank.wang@greature.com.cn
Country: China
ProdList: 147
Advantage: 58

Wuhan Dingxintong Pharmaceutical Co. , Ltd.

Tel: 15871722230
Fax: 2796190295
Email: 15871722230@163.com
Country: China
ProdList: 4686
Advantage: 58

Wuhan Wiseman Bioengineering Co.,Ltd

Tel: 13419526507 13419526507
Fax: 027-59506022
Email: 13419526507@163.com
Country: China
ProdList: 2845
Advantage: 58

Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
Fax: QQ：422450190
Email: 422450190@qq.com
Country: China
ProdList: 10308
Advantage: 58

Hubei Zhongshan Medical Technology Co., Ltd

Tel: 027-61907345 13397111514
Fax: 3443707954
Email: w13397111514@163.com
Country: China
ProdList: 1005
Advantage: 58

Shanghai Minkai Biological Technology Co., Ltd

Tel: 021-021-52919136 17315815539
Email: 2804155403@qq.com
Country: China
ProdList: 180
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824 18107960669
Fax: 18140514863
Email: 79046690@qq.com
Country: China
ProdList: 1242
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

SUZHOU MAYSIXTH TRADING CO.LTD

Tel: 17715515539
Email: zhangxin@maysixth.cn
Country: China
ProdList: 58
Advantage: 58

Nantong Feiyu Biological Technology CO.,LTD

Tel: 0513-68819626; 15152877458
Fax: 0513-68669626
Email: feiyubio@163.com
Country: China
ProdList: 4817
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824; 13184580281
Fax: 400-880-2824
Email: hj@ruiweier.cn
Country: China
ProdList: 2686
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824 15608648206
Email: 1987516016@qq.com
Country: China
ProdList: 2671
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 185-0276-2003 18502762003;
Email: 435918333@qq.com
Country: China
ProdList: 2213
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9960
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 027-59222918; 13385289472
Email: Z13385289472@163.com
Country: China
ProdList: 4767
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59105166; 13125137732
Email: 2853863890@qq.com
Country: China
ProdList: 2987
Advantage: 58

Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd.

Tel: 18671296875
Email: 1205035102@qq.com
Country: China
ProdList: 4302
Advantage: 58

Less

View Lastest Price from Omalizumab manufacturers

Hangzhou Huarong Pharm Co., Ltd.

Product: Omalizumab 242138-07-4
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99%
Supply Ability: 100KG
Release date: 2021-09-15

242138-07-4, OmalizumabRelated Search:

DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) COBALT(II) ACETYLACETONATE SALCOMINE Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) TERT-BUTYL ISOCYANIDE Ferric acetylacetonate Tris(2,4-pentanedionato)chroMiuM(III) Aluminum acetylacetonate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tosylmethyl isocyanide METHYL ISOCYANOACETATE Ethyl isocyanoacetate Cupric acetylacetonate N-BUTYLISOCYANIDE PHENYLSELENOL

OMALIZUMAB

Xolair

Immunoglobulin G1,anti-(human immunoglobulin E Fc region) (human-mouse monoclonal E25 clonepSVIE25 g-chain), disulfide withhuman-mouse monoclonal E25 clone pSVIE25 k-chain, dimer (9CI)

Research Grade Omalizumab(DHJ92701)

humanized,asthma,IgE,CD40,allergic,IL-4,IL-6,FcγRIIb,Olizumab,Inhibitor,immunoglobulin,FcεRI,rhuMab-E25,Omalizumab,inhibit

Omalizumab (anti-IgE)

Research Grade Omalizumab

Omalizumab - buffer solution

Omalizumab 75.4mg/ml

242138-07-4