ChemicalBook > CAS DataBase List > Ethyl 3-(benzylamino)propanoate

Ethyl 3-(benzylamino)propanoate

Product Name
Ethyl 3-(benzylamino)propanoate
CAS No.
23583-21-3
Chemical Name
Ethyl 3-(benzylamino)propanoate
Synonyms
bzl-á-ala-oet;Bzl-beta-Ala-OEt;ethyl N-benzyl-beta-alaninate;N-Benzyl-b-alanine ethyl ester;n-benzyl-á-alanine ethyl ester;N-Benzyl-β-alanine Ethyl Ester;ETHYL 3-(BENZYLAMINO)PROPIONATE;ETHYL 3-(BENZYLAMINO)PROPANOATE;N-BENZYL-SS-ALANINE ETHYL ESTER;Ethyl 4-(benzylamino)propanoate
CBNumber
CB1468315
Molecular Formula
C12H17NO2
Formula Weight
207.27
MOL File
23583-21-3.mol
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Ethyl 3-(benzylamino)propanoate Property

Boiling point:
150 °C
Density 
1.017 g/mL at 25 °C
refractive index 
1.503
Flash point:
150°C/0.2mm
storage temp. 
-20°C
pka
8.57±0.19(Predicted)
form 
clear liquid
color 
Colorless to Almost colorless
InChI
InChI=1S/C12H17NO2/c1-2-15-12(14)8-9-13-10-11-6-4-3-5-7-11/h3-7,13H,2,8-10H2,1H3
InChIKey
HCTJHQFFNDLDPF-UHFFFAOYSA-N
SMILES
C(C1C=CC=CC=1)NCCC(=O)OCC
CAS DataBase Reference
23583-21-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/38-52/53-22
Safety Statements 
26-36/37/39-61
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
700959
Product name
Ethyl 3-(benzylamino)propionate
Purity
97%
Packaging
25g
Price
$76
Updated
2023/06/20
Sigma-Aldrich
Product number
700959
Product name
Ethyl 3-(benzylamino)propionate
Purity
97%
Packaging
5g
Price
$35.8
Updated
2023/01/07
TCI Chemical
Product number
B1579
Product name
Ethyl 3-(Benzylamino)propionate
Purity
>95.0%(GC)
Packaging
25mL
Price
$26
Updated
2025/07/31
TCI Chemical
Product number
B1579
Product name
Ethyl 3-(Benzylamino)propionate
Purity
>95.0%(GC)
Packaging
500mL
Price
$467
Updated
2025/07/31
TRC
Product number
B232975
Product name
N-Benzyl-β-alanineEthylEster
Packaging
50g
Price
$250
Updated
2021/12/16
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Ethyl 3-(benzylamino)propanoate Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

N-Benzyl-β-alanine Ethyl Ester is used as a reagent in organic synthesis including that of dipivaloyloxyphenyl aminopropionate β-agonist prodrugs which are used in the treatment of psoriasis. It is also used in the synthesis of N,N''-dithiobis(N-benzyl-β-alanine) dethyl ester, which is an important intermediate of insecticide OK-135, and in synthesis of spiropiperidine-based orexin-2 receptor (OX2R) antagonists.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

100-46-9

140-88-5

23583-21-3

6938-07-4

GENERAL METHODS: Benzylamine (7.5 mmol) was mixed with ethyl acrylate (5 mmol) in a molar ratio of 1.5:1 under acidic alumina (1 g, 200 mol%) as a catalyst and the reaction was carried out by refluxing under stirring. The reaction was heated by oil bath and the progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography (GC) until completion. After completion of the reaction, it was cooled to room temperature and the catalyst was removed by filtration through filter paper. The catalyst was rinsed with a solvent mixture of ethyl acetate/hexane and the filtrate was subsequently concentrated by rotary evaporation. The crude product was purified by silica gel column chromatography, using hexane/ethyl acetate as eluent of choice. For aliphatic amine derivatives, a hexane/ethyl acetate ratio of 7:3, 6:4, or 5:5 was typically used to elute the monoadducts, while for aromatic compounds, a hexane/ethyl acetate ratio of 8:2 was used. The yields of the purified products were recorded and infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) analyses were performed to confirm the product structures.

References

[1] Molecules, 2016, vol. 21, # 6,
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 971
[3] New Journal of Chemistry, 2004, vol. 28, # 2, p. 183 - 184
[4] Synthetic Communications, 2013, vol. 43, # 5, p. 758 - 767

Ethyl 3-(benzylamino)propanoate Preparation Products And Raw materials

Raw materials

Benzylamine Methanol Ethyl acrylate

Preparation Products

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View Lastest Price from Ethyl 3-(benzylamino)propanoate manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Ethyl 3-(benzylamino)propanoate 23583-21-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-04-12
Career Henan Chemical Co
Product
Ethyl 3-(benzylamino)propanoate 23583-21-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-08

23583-21-3, Ethyl 3-(benzylamino)propanoateRelated Search:

β-Alanine Tris(trimethylsilyl)phosphate Benzocaine Benzyl bromide EC 2.6.1.2 Ethylparaben Ethyl cyanoacetate Ethanol ISOXADIFEN-ETHYL D-Alanine Benzyl alcohol Benzyl benzoate 2-AMINODIETHYLMALONATE Phenprobamate Ethyl formate Ethyl pyruvate Ethyl propionate Urethane

  • N-Benzyl-beta-alanine Ethyl Ester N-Benzyl-3-aminopropionic Acid Ethyl Ester
  • Ethyl 3-(BenzylaMino)propionate , 95.0%(GC)
  • Ethyl 3-(benzylamino)propionate 97%
  • N-(Phenylmethyl)-b-alanine ethyl ester
  • Bzl-beta-Ala-OEt~Ethyl 3-(benzylamino)propionate
  • ethyl N-benzyl-beta-alaninate
  • ETHYL N-BENZYL-3-AMINOPROPIONATE
  • ETHYL 3-(BENZYLAMINO)PROPANOATE
  • ETHYL 3-(BENZYLAMINO)PROPIONATE
  • 3-BENZYLAMINO PROPIONIC ACID ETHYL ESTER
  • benzylaminopropionicacidethylester
  • N-BENZYL-BETA-ALANINE ETHYL ESTER
  • N-BENZYL-3-AMINOPROPIONIC ACID ETHYL ESTER
  • Bzl-beta-Ala-OEt
  • N-Benzyl-b-alanine ethyl ester
  • N-Benzyl-~-alanineethylester,98%
  • bzl-á-ala-oet
  • n-benzyl-á-alanine ethyl ester
  • N-BENZYL-SS-ALANINE ETHYL ESTER
  • N-Benzyl-β-alanine ethyl ester, 98%
  • 3-(Benzylamino)propionic acid ethyl ester, N-Benzyl-β-alanine ethyl ester
  • Ethyl 4-(benzylamino)propanoate
  • Ethyl=3-(N-benzylamino)propionate
  • N-Benzyl-3-aminopropionic acid ethyl ester ,98%
  • Ethyl 3-(Benzylamino)propionate &gt
  • N-BENZYL-3-AMINOPROPIONIC ACID ETHYL ESTE
  • Ethyl 3-(benzylamino)propanoate USP/EP/BP
  • N-Benzyl-β-alanine Ethyl Ester
  • β-Alanine, N-(phenylmethyl)-, ethyl ester
  • 23583-21-3
  • C6H5CH2NHCH2CH2CO2CH2CH3
  • AMINE
  • Phenyls & Phenyl-Het
  • Aromatic Cinnamic Acids, Esters and Derivatives
  • Esters
  • Phenyls & Phenyl-Het