Ethyl 3-(benzylamino)propanoate
- Product Name
- Ethyl 3-(benzylamino)propanoate
- CAS No.
- 23583-21-3
- Chemical Name
- Ethyl 3-(benzylamino)propanoate
- Synonyms
- bzl-á-ala-oet;Bzl-beta-Ala-OEt;ethyl N-benzyl-beta-alaninate;N-Benzyl-b-alanine ethyl ester;n-benzyl-á-alanine ethyl ester;N-Benzyl-β-alanine Ethyl Ester;ETHYL 3-(BENZYLAMINO)PROPIONATE;ETHYL 3-(BENZYLAMINO)PROPANOATE;N-BENZYL-SS-ALANINE ETHYL ESTER;Ethyl 4-(benzylamino)propanoate
- CBNumber
- CB1468315
- Molecular Formula
- C12H17NO2
- Formula Weight
- 207.27
- MOL File
- 23583-21-3.mol
Ethyl 3-(benzylamino)propanoate Property
- Boiling point:
- 150 °C
- Density
- 1.017 g/mL at 25 °C
- refractive index
- 1.503
- Flash point:
- 150°C/0.2mm
- storage temp.
- -20°C
- pka
- 8.57±0.19(Predicted)
- form
- clear liquid
- color
- Colorless to Almost colorless
- InChI
- InChI=1S/C12H17NO2/c1-2-15-12(14)8-9-13-10-11-6-4-3-5-7-11/h3-7,13H,2,8-10H2,1H3
- InChIKey
- HCTJHQFFNDLDPF-UHFFFAOYSA-N
- SMILES
- C(C1C=CC=CC=1)NCCC(=O)OCC
- CAS DataBase Reference
- 23583-21-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/38-52/53-22
- Safety Statements
- 26-36/37/39-61
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 700959
- Product name
- Ethyl 3-(benzylamino)propionate
- Purity
- 97%
- Packaging
- 25g
- Price
- $76
- Updated
- 2023/06/20
- Product number
- 700959
- Product name
- Ethyl 3-(benzylamino)propionate
- Purity
- 97%
- Packaging
- 5g
- Price
- $35.8
- Updated
- 2023/01/07
- Product number
- B1579
- Product name
- Ethyl 3-(Benzylamino)propionate
- Purity
- >95.0%(GC)
- Packaging
- 25mL
- Price
- $26
- Updated
- 2025/07/31
- Product number
- B1579
- Product name
- Ethyl 3-(Benzylamino)propionate
- Purity
- >95.0%(GC)
- Packaging
- 500mL
- Price
- $467
- Updated
- 2025/07/31
- Product number
- B232975
- Product name
- N-Benzyl-β-alanineEthylEster
- Packaging
- 50g
- Price
- $250
- Updated
- 2021/12/16
Ethyl 3-(benzylamino)propanoate Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
N-Benzyl-β-alanine Ethyl Ester is used as a reagent in organic synthesis including that of dipivaloyloxyphenyl aminopropionate β-agonist prodrugs which are used in the treatment of psoriasis. It is also used in the synthesis of N,N''-dithiobis(N-benzyl-β-alanine) dethyl ester, which is an important intermediate of insecticide OK-135, and in synthesis of spiropiperidine-based orexin-2 receptor (OX2R) antagonists.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
100-46-9
140-88-5
23583-21-3
6938-07-4
GENERAL METHODS: Benzylamine (7.5 mmol) was mixed with ethyl acrylate (5 mmol) in a molar ratio of 1.5:1 under acidic alumina (1 g, 200 mol%) as a catalyst and the reaction was carried out by refluxing under stirring. The reaction was heated by oil bath and the progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography (GC) until completion. After completion of the reaction, it was cooled to room temperature and the catalyst was removed by filtration through filter paper. The catalyst was rinsed with a solvent mixture of ethyl acetate/hexane and the filtrate was subsequently concentrated by rotary evaporation. The crude product was purified by silica gel column chromatography, using hexane/ethyl acetate as eluent of choice. For aliphatic amine derivatives, a hexane/ethyl acetate ratio of 7:3, 6:4, or 5:5 was typically used to elute the monoadducts, while for aromatic compounds, a hexane/ethyl acetate ratio of 8:2 was used. The yields of the purified products were recorded and infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) analyses were performed to confirm the product structures.
References
[1] Molecules, 2016, vol. 21, # 6,
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 971
[3] New Journal of Chemistry, 2004, vol. 28, # 2, p. 183 - 184
[4] Synthetic Communications, 2013, vol. 43, # 5, p. 758 - 767
Ethyl 3-(benzylamino)propanoate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 3-(benzylamino)propanoate Suppliers
- Tel
- --
- Fax
- --
- y.barysheva@ukrorgsynth.com
- Country
- Ukraine
- ProdList
- 6230
- Advantage
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View Lastest Price from Ethyl 3-(benzylamino)propanoate manufacturers
- Product
- Ethyl 3-(benzylamino)propanoate 23583-21-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-04-12
- Product
- Ethyl 3-(benzylamino)propanoate 23583-21-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-08