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4-DiMethylaMino Antipyrine

Product Name
4-DiMethylaMino Antipyrine
CAS No.
58-15-1
Chemical Name
4-DiMethylaMino Antipyrine
Synonyms
Febron;Dereuma;Dipirin;Dipyrin;Hyparon;Pirazon;Piridol;Amidozon;Amidofen;Dipyrine
CBNumber
CB1476086
Molecular Formula
C13H17N3O
Formula Weight
231.29
MOL File
58-15-1.mol
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4-DiMethylaMino Antipyrine Property

Melting point:
107-109 °C(lit.)
Boiling point:
373.38°C (rough estimate)
Density 
1.0744 (rough estimate)
refractive index 
1.6140 (estimate)
storage temp. 
Refrigerator
pka
pKa 5.0 (Uncertain)
form 
Crystalline Powder, Crystals and/or Chunks
color 
Off-white to brownish
Water Solubility 
5.55 g/100 mL
Sensitive 
Air & Light Sensitive
Merck 
14,474
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water.
InChIKey
RMMXTBMQSGEXHJ-UHFFFAOYSA-N
CAS DataBase Reference
58-15-1(CAS DataBase Reference)
NIST Chemistry Reference
Aminopyrine(58-15-1)
EPA Substance Registry System
Aminopyrine (58-15-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-21/22
Safety Statements 
26-36-36/37/39
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
CD2625000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29331190
Hazardous Substances Data
58-15-1(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 1.7 g/kg (Hart)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D8015
Product name
4-Dimethylaminoantipyrine
Purity
reactive nitrogen species scavenger
Packaging
25g
Price
$68.9
Updated
2021/03/22
Sigma-Aldrich
Product number
D8015
Product name
4-Dimethylaminoantipyrine
Purity
reactive nitrogen species scavenger
Packaging
100g
Price
$190
Updated
2021/03/22
Alfa Aesar
Product number
B21436
Product name
4-(Dimethylamino)antipyrine, 98+%
Packaging
250g
Price
$165
Updated
2020/06/24
Alfa Aesar
Product number
B21436
Product name
4-(Dimethylamino)antipyrine, 98+%
Packaging
50g
Price
$45.3
Updated
2020/06/24
Cayman Chemical
Product number
15770
Product name
Aminophenazone
Purity
≥98%
Packaging
25g
Price
$59
Updated
2021/03/22
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4-DiMethylaMino Antipyrine Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

Antipyretic; analgesic.

Uses

Antipyretic;ACTH secretor

Definition

ChEBI: A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic proper ies.

brand name

Adexogan;Agevis;Algimicin anttitermico;Amidazopen;Amidozen;Anoixal;Antigripina;Areumal;Axiston;Balbion;Barsedan;Baukal suppositories;Bayer 1387 p;Bronchisan;Brufaneuseol;Butapyrine;Capsyka dr knapf;Capysal;Chinopyrin;Cibalgin;Ciclazon;Clinit;Coffan;Compral;Cusayth;Demolpas;Dentigoa;Depiral c;Dexa escopyrin;Dha 51;Dialpyrin;Digisab;Dimametten;Dimopyrin;Diprin;Dolo-attirin;Dolo-optineural;Dolorphen;Dolovosano;Donobin;Duerin;Dysmensan;Escopyrinus;Espasnatex;Eufibran;Euprogan;Febren;Febrosolvin;Fenodone;Fever;Flivalgin;Flumil;Framidone;Ftalazon;Funapon;Galenopyrin;Glucopirina;Glucopitina;Helvagit-f;Hemicraneal;Hisense-p;Influnal depot;Inst;Irgapyrine;Isoftal;Kalmine;Katareuma;Lagaflex;Latepyrine;Lauroanginol;Manslu;Medispanmin;Meloka;Neuro-demoplast;Nifedon;Nikartrone;Nostress;Optineural(analgesic);Optipax;Osadrine;Osmotipax;P.s.b.p.;Piracodid;Piradenil;Piradol;Pirasco;Piraseptolo.

World Health Organization (WHO)

Aminophenazone, a pyrazolone derivative, has been used as an antiinflammatory and analgesic agent for over a century. Its use has been associated with cases of bone marrow depression and agranulocytosis and more recently it has been claimed to have a carcinogenic potential. Products containing aminophenazone have been formally withdrawn in many countries and marketing has been voluntarily suspended in others. Elsewhere, however, proprietary preparations containing this ingredient may remain available. (Reference: (WHODI) WHO Drug Information, 3, 9, 1977)

General Description

Small colorless crystals or white crystalline powder. Aqueous solution slightly alkaline to litmus. pH (5% water solution) 7.5-9. Odorless. Slightly bitter taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

Aminophenazone is sensitive to exposure to light. Aminophenazone is readily attacked by mild oxidizing agents in the presence of water. Aminophenazone is incompatible with acacia, apomorphine, aspirin, chloral hydrate, iodine and tannic acid.

Fire Hazard

Flash point data for Aminophenazone are not available; however, Aminophenazone is probably combustible.

Safety Profile

Human poison by unspecified route. Experimental poison by ingestion, subcutaneous, intramuscular,intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic and reproductive effects. Questionable carcinogen when mixed with NaNO2 (1:l). Mutation data reported. Can cause bone marrow depression resulting in leucopenia. Has been implicated in development of aplastic anemia. A tranquilizer. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

It crystallises from pet ether, sublimes between 80o and 90o, and forms metal complexes. [Beilstein 25 H 452, 25 III/IV 3555.]

4-DiMethylaMino Antipyrine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-DiMethylaMino Antipyrine manufacturers

Shanxi Lianxu New Material Co., LTD
Product
4-DiMethylaMino Antipyrine 58-15-1
Price
US $44.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg/month
Release date
2021-10-21
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
4-DiMethylaMino Antipyrine 58-15-1
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-24
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
AMinophenazone 58-15-1
Price
US $0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50kg
Release date
2020-12-15

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