ChemicalBook > CAS DataBase List > SU 9516

SU 9516

Product Name
SU 9516
CAS No.
377090-84-1
Chemical Name
SU 9516
Synonyms
CS-1784;SU 9516;SU-9516;SU 9516 USP/EP/BP;3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one;(Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one;3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one;(3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)-;Apoptosis,Autophagy,SU-9516,SU 9516,SU9516,inhibit,CDK,Cyclin dependent kinase,Inhibitor
CBNumber
CB1497100
Molecular Formula
C13H11N3O2
Formula Weight
241.25
MOL File
377090-84-1.mol
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SU 9516 Property

storage temp. 
Store at +4°C
solubility 
DMSO: ~17 mg/mL
form 
crystalline
color 
brown
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14796
Product name
SU 9516
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14796
Product name
SU 9516
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
14796
Product name
SU 9516
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
14796
Product name
SU 9516
Purity
≥98%
Packaging
25mg
Price
$305
Updated
2024/03/01
TRC
Product number
S688045
Product name
SU9516
Packaging
5mg
Price
$235
Updated
2021/12/16
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SU 9516 Chemical Properties,Usage,Production

Uses

SU 9516 is a 3-substituted indolinone CDK inhibitor with potent and selective inhibition towards cyclin-dependant kinases.

Definition

ChEBI: 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one is a member of indoles.

Biological Activity

Potent, selective cdk2 inhibitor (IC 50 values are 0.022, 0.04, >10, >10, 18 and >100 μ M for cdk2, cdk1, cdk4, PKC, p38, PDGFR and EGFR respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G 1 and G 2 -M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro .

References

[1]. lane me, yu b, rice a, et al. a novel cdk2-selective inhibitor, su9516, induces apoptosis in colon carcinoma cells. cancer res, 2001, 61(16): 6170-6177.
[2]. yu b, lane me, wadler s. su9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight e2f complexes in human colon carcinoma cells. biochem pharmacol, 2002, 64(7): 1091-1100.
[3]. gao n, kramer l, rahmani m, et al. the three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3h-imidazol-4-yl)-meth-(z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (su9516) kills human leukemia cells via down-regulation of mcl-1 through a transcriptional mechanism. mol pharmacol, 2006, 70(2): 645-655.

SU 9516 Preparation Products And Raw materials

Raw materials

Preparation Products

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SU 9516 Suppliers

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View Lastest Price from SU 9516 manufacturers

Career Henan Chemical Co
Product
3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one 377090-84-1
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

377090-84-1, SU 9516Related Search:

SU 9516 NU6102 OLOMOUCINE SB 431542 PD 0325901 BI-97C1 PF-3758309 Obatoclax mesilate PURVALANOL A 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE OLOMOUCINE II N9-ISOPROPYL-OLOMOUCINE (S)-ROSCOVITINE SU 6656 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE SU 5416 SU 5205 SU4312

  • 3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
  • CS-1784
  • 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one
  • SU 9516;SU-9516
  • (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one
  • (Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one
  • (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one SU9516
  • (3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one
  • 2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)-
  • SU 9516 USP/EP/BP
  • Apoptosis,Autophagy,SU-9516,SU 9516,SU9516,inhibit,CDK,Cyclin dependent kinase,Inhibitor
  • 377090-84-1
  • Enzyme Inhibitors by Enzyme
  • Intracellular Signaling
  • Inhibitors
  • A to
  • Cyclin Dependant Kinase 2Serine/Threonine Kinase Biology
  • Cyclin-Dependent Kinase (CDK)Cell Signaling and Neuroscience
  • Kinase/Phosphatase Biology
  • Protein Kinase Inhibitors
  • Serine/Threonine Kinase Inhibitors