SU 9516
- Product Name
- SU 9516
- CAS No.
- 377090-84-1
- Chemical Name
- SU 9516
- Synonyms
- CS-1784;SU 9516;SU-9516;SU 9516 USP/EP/BP;3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one;(Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one;3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one;(3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)-;Apoptosis,Autophagy,SU-9516,SU 9516,SU9516,inhibit,CDK,Cyclin dependent kinase,Inhibitor
- CBNumber
- CB1497100
- Molecular Formula
- C13H11N3O2
- Formula Weight
- 241.25
- MOL File
- 377090-84-1.mol
SU 9516 Property
- storage temp.
- Store at +4°C
- solubility
- DMSO: ~17 mg/mL
- form
- crystalline
- color
- brown
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 14796
- Product name
- SU 9516
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 14796
- Product name
- SU 9516
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 14796
- Product name
- SU 9516
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 14796
- Product name
- SU 9516
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $305
- Updated
- 2024/03/01
- Product number
- S688045
- Product name
- SU9516
- Packaging
- 5mg
- Price
- $235
- Updated
- 2021/12/16
SU 9516 Chemical Properties,Usage,Production
Uses
SU 9516 is a 3-substituted indolinone CDK inhibitor with potent and selective inhibition towards cyclin-dependant kinases.
Definition
ChEBI: 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one is a member of indoles.
Biological Activity
Potent, selective cdk2 inhibitor (IC 50 values are 0.022, 0.04, >10, >10, 18 and >100 μ M for cdk2, cdk1, cdk4, PKC, p38, PDGFR and EGFR respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G 1 and G 2 -M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro .
References
[1]. lane me, yu b, rice a, et al. a novel cdk2-selective inhibitor, su9516, induces apoptosis in colon carcinoma cells. cancer res, 2001, 61(16): 6170-6177.
[2]. yu b, lane me, wadler s. su9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight e2f complexes in human colon carcinoma cells. biochem pharmacol, 2002, 64(7): 1091-1100.
[3]. gao n, kramer l, rahmani m, et al. the three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3h-imidazol-4-yl)-meth-(z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (su9516) kills human leukemia cells via down-regulation of mcl-1 through a transcriptional mechanism. mol pharmacol, 2006, 70(2): 645-655.
SU 9516 Preparation Products And Raw materials
Raw materials
Preparation Products
SU 9516 Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from SU 9516 manufacturers
- Product
- 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one 377090-84-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23