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Vosoritide acetate

Product Name: Vosoritide acetate
CAS No.: 1480724-61-5
Chemical Name: Vosoritide acetate
Synonyms: vosoritide;unii-7se5582q2p;Vosoritide acetate
CBNumber: CB15508225
Formula Weight: 0
MOL File: Mol file

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Vosoritide acetate Property

form: Solid
color: White to off-white
Sequence: H-Pro-Gly-Gln-Glu-His-Pro-Asn-Ala-Arg-Lys-Tyr-Lys-Gly-Ala-Asn-Lys-Lys-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-OH(Disulfide bridge:Cys23-Cys7)

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Hazard and Precautionary Statements (GHS)

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Vosoritide acetate Chemical Properties,Usage,Production

Uses

Vosoritide acetate is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].

Side effects

The most common side effects of Vosoritide acetate include injection site reactions (such as swelling, redness, itching, or pain), vomiting, and decreased blood pressure.

in vivo

Vosoritide (subcutaneous injection; 800 μg/kg; once daily; 20 d) treatment leads to improvement in skeletal parameters in Fgfr3 gain-of-function mutation mouse^[3].

Animal Model:	Fgfr3^Y367C/+ mice^[3]
Dosage:	800 μg/kg
Administration:	Subcutaneous injection; 800 μg/kg; once daily; 20 days
Result:	Observed phenotypic changes including flattening of the skull, elongation of the snout, improvement of the anterior crossbite, larger paws and digits, and longer and straightened tibias and femurs.

References

[1] Duggan S. Vosoritide: First Approval. Drugs. 2021 Nov;81(17):2057-2062. DOI:10.1007/s40265-021-01623-w
[2] Shuhaibar LC, et al. Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth. JCI Insight. 2021 May 10;6(9):e141426. DOI:10.1172/jci.insight.141426
[3] Lorget F, et al. Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia. Am J Hum Genet. 2012 Dec 7;91(6):1108-14. DOI:10.1016/j.ajhg.2012.10.014

Vosoritide acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vosoritide acetate manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: Vosoritide acetate 1480724-61-5
Price: US $1.00/g
Min. Order: 0.10000000g
Purity: 99%
Supply Ability: 200kg
Release date: 2025-11-06

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Purity: 98%
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Release date: 2025-06-20

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Product: Vosoritide Acetate 1480724-61-5
Price: US $0.00/kg
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Release date: 2025-04-01

1480724-61-5, Vosoritide acetateRelated Search:

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Vosoritide acetate

vosoritide

unii-7se5582q2p

1480724-61-5