ChemicalBook > CAS DataBase List > 6-Chloropurine

6-Chloropurine

Product Name
6-Chloropurine
CAS No.
87-42-3
Chemical Name
6-Chloropurine
Synonyms
6-CHLORO-9H-PURINE;ClP;6-CHLORO-7H-PURINE;6-CP;6-chloro-5H-purine;x47;X 47;nsc744;sk6048;NSC 744
CBNumber
CB1726169
Molecular Formula
C5H3ClN4
Formula Weight
154.56
MOL File
87-42-3.mol
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6-Chloropurine Property

Melting point:
>300 °C (dec.) (lit.)
Boiling point:
254.17°C (rough estimate)
Density 
1.4649 (rough estimate)
refractive index 
1.8430 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
5 g/L
form 
crystalline
pka
7.47±0.20(Predicted)
color 
yellow-orange
biological source
mouse
Water Solubility 
5 g/L
Merck 
14,2161
BRN 
5774
InChIKey
ZKBQDFAWXLTYKS-UHFFFAOYSA-N
CAS DataBase Reference
87-42-3(CAS DataBase Reference)
NIST Chemistry Reference
6-Chloropurine(87-42-3)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
WGK Germany 
3
RTECS 
UO7520000
F 
10-23
HazardClass 
IRRITANT
HS Code 
29335990
Toxicity
LD50 oral in mouse: 720mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
161179
Product name
6-Chloropurine
Purity
≥99%
Packaging
5g
Price
$68.8
Updated
2024/03/01
TCI Chemical
Product number
C0278
Product name
6-Chloropurine
Purity
>98.0%(T)
Packaging
5g
Price
$73
Updated
2024/03/01
TCI Chemical
Product number
C0278
Product name
6-Chloropurine
Purity
>98.0%(T)
Packaging
25g
Price
$161
Updated
2024/03/01
Alfa Aesar
Product number
A11202
Product name
6-Chloropurine, 99%
Packaging
1g
Price
$25.65
Updated
2024/03/01
Alfa Aesar
Product number
A11202
Product name
6-Chloropurine, 99%
Packaging
5g
Price
$73.65
Updated
2024/03/01
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6-Chloropurine Chemical Properties,Usage,Production

Chemical Properties

It is a pale yellow crystal with relatively stable chemical properties that do not cause decomposition at room temperature. Its structure includes nitrogen heterocycles, which give rise to remarkable alkalinity and the formation of volatile acid salts. It is soluble in dimethyl sulfoxide, but has only slight solubility in water.

Uses

6-Chloropurine is used in the preparation of 9-alkylpurines through alkylation with various substituted alkyl halides in dimethyl sulfoxide. It is also used to prepare 6-succinoaminopurine.

Definition

ChEBI: 6-Chloro-1H-purine is a member of purines. It is metabolized to form 6-mercaptopurine and has been used as an antineoplastic.

Preparation

6-chloropurine is synthesized by reacting hypoxanthine with phosphoryl chloride in the presence of an unreactive base such as dimethyl aniline. It may likewise be formed by heating hypoxanthine under pressure with phosphoryl chloride as well as with a reagent prepared by adding water, preferably about by volume, to dry phosphoryl chloride.
US2832781A

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 1928, 1956 DOI: 10.1021/ja01590a043

General Description

The acid-catalyzed reaction of 6-chloropurine with 3,4-di-O-acetyl-D-xylal has been investigated.

Purification Methods

6-Chloropurine crystallises from water. The UV in water at pH 1 has 264nm (log 3.94). [Beilstein 26 III/IV 1742.]

6-Chloropurine Preparation Products And Raw materials

Raw materials

Preparation Products

6-Dimethylaminopurine Adenine 6-ETHOXYPURINE 6-CYANOPURINE 6-benzylaminopurine 6-ETHYLMERCAPTOPURINE 6-BENZYLOXYPURINE 6-N-BUTOXYPURINE 6-Iodopurine
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6-Chloropurine Suppliers

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View Lastest Price from 6-Chloropurine manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
6-Chloropurine 87-42-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-20
Xinxiang Aurora Biotechnology Co.,Ltd.
Product
6-Chloropurine 87-42-3
Price
US $0.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20Ton
Release date
2024-10-22
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
6-Chloropurine 87-42-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2025-01-10

87-42-3, 6-ChloropurineRelated Search:

Allopurinol Purine Guanine Adenine Azathioprine 2,6-Dichloropurine 6-CHLORO-9-(TETRAHYDRO-2-PYRANYL)-PURINE 2-Amino-6-chloro-9H-purine-9-riboside,2-Amino-6-chloropurine-9-b-D-riboside 6-Chloropurine ribonucleoside 6-Chloro-7H-purine-2-amine,2-Amino-6-chloro-9H-purine 99%,2-Amino-6-chloro-9H-purine,2-Amino-6-Chloropurine(6-Chloroguanine),2-AMINO-6-CHLOROPURINE 2,6,8-TRICHLOROPURINE 6-CHLOROPURINE-2'-DEOXYRIBOSIDE 2,6-Dichloro-7-methylpurine CHLOROPURINE, 6-,6-CHLORO-9H-PURINE 6-Chloro-2-fluoropurine 6-Amino-9-(2-chloro-6-fluorobenzyl)purine 8-Chloro-7H-purine 2-AMINO-6-CHLOROPURINE, 99+%

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  • 1H-Purine, 6-chloro-
  • 6-chloro-1h-purin
  • 6-chloro-1h-purine
  • 6-chloro-purin
  • 6-Chlorpurine
  • ClP
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  • TIMTEC-BB SBB004030
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  • 1H-Purine, 6-chloro- (9CI)
  • AKOS BBS-00002143
  • 6-CHLOROPURINE
  • 6-CHLORO-7H-PURINE
  • 6-CHLORO-9H-PURINE
  • 6-CP
  • CHLOROPURINE, 6-
  • 6-CHLOROPURINE YELLOW CRYSTALS
  • 6-CHLOROPURINE, 99+%
  • 6-Chloropurine Other Name 6-Chloro-1H-purine
  • 6-Chloro-9H-purine 97%
  • Chloropurine Chloropurine
  • 6-Chloropurine&gt
  • oropurine
  • 6-Chloropurine USP/EP/BP
  • 6-chloro-5H-purin
  • 87-42-3
  • C5H3N4Cl
  • Purines
  • BioChemical
  • Building Blocks
  • Biochemicals and Reagents
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleosides
  • Building Blocks
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Biochemicals and Reagents
  • Nucleosides