4-IODO-7-AZAINDOLE
- Product Name
- 4-IODO-7-AZAINDOLE
- CAS No.
- 319474-34-5
- Chemical Name
- 4-IODO-7-AZAINDOLE
- Synonyms
- 4-IODO-7-AZAINDOLE;4-IODO-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 4-iodo-
- CBNumber
- CB1737396
- Molecular Formula
- C7H5IN2
- Formula Weight
- 244.03
- MOL File
- 319474-34-5.mol
4-IODO-7-AZAINDOLE Property
- Density
- 2.082
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 13.08±0.40(Predicted)
- Appearance
- Light brown to yellow Solid
- InChI
- InChI=1S/C7H5IN2/c8-6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)
- InChIKey
- PCHGYPNRADCIKG-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=C(I)C=CN=2
- CAS DataBase Reference
- 319474-34-5
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000928
- Product name
- 4-Iodo-1H-pyrrolo[2,3-b]pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- 3H32-H-58
- Product name
- 4-Iodo-7-azaindole
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 026227
- Product name
- 4-Iodo-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 100mg
- Price
- $237
- Updated
- 2021/12/16
- Product number
- 3H32-H-58
- Product name
- 4-Iodo-7-azaindole
- Packaging
- 1g
- Price
- $675
- Updated
- 2021/12/16
- Product number
- HCH0040914
- Product name
- 4-IODO-1H-PYRROLO[2,3-B]PYRIDINE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $837.38
- Updated
- 2021/12/16
4-IODO-7-AZAINDOLE Chemical Properties,Usage,Production
Synthesis
55052-28-3
319474-34-5
Part 2: Synthesis of 4-iodo-1H-pyrrolo[2,3-b]pyridine: To a mixture of 4-chloro-1H-pyrrolo[2,3-b]pyridine (12.9 g, 84.3 mmol) and NaI (40 g, 168 mmol) in acetonitrile (150 mL) was slowly added acetyl chloride (12.6 mL, 176 mmol). The reaction mixture was stirred at 80 °C for 4 days, followed by removal of excess acetonitrile by distillation under reduced pressure. To the residue was added 300 mL of 10% K2CO3 (aqueous solution) and extracted with CH2Cl2 (3 x 100 mL). The combined organic phases were washed sequentially with 10% sodium bisulfite (aqueous) and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product (22.2 g). The crude product was dissolved in THF (150 mL) and 1 M NaOH (100 mL) was added. The mixture was stirred at room temperature for 2 h. The solvent was subsequently evaporated under reduced pressure, diluted with water and extracted with CH2Cl2. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting brown solid was purified by silica gel column chromatography and recrystallized with acetonitrile to give pure 4-iodo-1H-pyrrolo[2,3-b]pyridine (9.75 g, 48% yield). Mass spectrum (ES+): 245 [MH+].
References
[1] Journal of Medicinal Chemistry, 2018,
[2] Tetrahedron Letters, 2007, vol. 48, # 9, p. 1527 - 1529
[3] Patent: US2004/186124, 2004, A1. Location in patent: Page/Page column 14
[4] Patent: US2011/282056, 2011, A1. Location in patent: Page/Page column 16
[5] Patent: WO2014/121883, 2014, A1. Location in patent: Page/Page column 54
4-IODO-7-AZAINDOLE Preparation Products And Raw materials
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View Lastest Price from 4-IODO-7-AZAINDOLE manufacturers
- Product
- 4-IODO-7-AZAINDOLE 319474-34-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-03