ChemicalBook > CAS DataBase List > 5-Bromo-2-nitropyridine

5-Bromo-2-nitropyridine

Product Name
5-Bromo-2-nitropyridine
CAS No.
39856-50-3
Chemical Name
5-Bromo-2-nitropyridine
Synonyms
2-NITRO-5-BROMOPYRIDINE;AKOS BBS-00001330;5-Bromo-2-nitropyrid;3-BROMO-6-NITROPYRIDINE;5-BROMO-2-NITROPYRIDINE;5-Bromo-2-notropyridine;2-Nitro-5-borMopyridine;Palbociclib impurity A;Pyridine, 5-broMo-2-nitro-;5-Bromo-2-nitropyridine 99%
CBNumber
CB1773370
Molecular Formula
C5H3BrN2O2
Formula Weight
202.99
MOL File
39856-50-3.mol
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5-Bromo-2-nitropyridine Property

Melting point:
148-150 °C (lit.)
Boiling point:
292.3±20.0 °C(Predicted)
Density 
1.833±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
-4.95±0.22(Predicted)
color 
White to yellow to beige powder or crystal or chunks
BRN 
120878
InChI
InChI=1S/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H
InChIKey
ATXXLNCPVSUCNK-UHFFFAOYSA-N
SMILES
C1([N+]([O-])=O)=NC=C(Br)C=C1
CAS DataBase Reference
39856-50-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
520411
Product name
5-Bromo-2-nitropyridine
Purity
99%
Packaging
5g
Price
$23.76
Updated
2024/03/01
TCI Chemical
Product number
B2766
Product name
5-Bromo-2-nitropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
B2766
Product name
5-Bromo-2-nitropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$57
Updated
2024/03/01
Alfa Aesar
Product number
L19748
Product name
5-Bromo-2-nitropyridine, 98+%
Packaging
5g
Price
$90.65
Updated
2024/03/01
Alfa Aesar
Product number
L19748
Product name
5-Bromo-2-nitropyridine, 98+%
Packaging
1g
Price
$30.6
Updated
2021/12/16
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5-Bromo-2-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Colorless solid

Uses

5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.

Preparation

5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. N-Bromosuccinimide (NBS) bromination of 2-aminopyridine in acetonitrile at 0-5 °C delivered 5-bromo-2- aminopyridine with good regioselectivity (>20:1). The brominated amino-pyridine was then reacted with the oxidant mixture, yielding 5-Bromo-2-nitropyridine after dilution with water and isopropanol[1].

Synthesis Reference(s)

[1] Agosti, Alessandro, et al. "Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5-Bromo-2-nitropyridine." Organic Process Research & Development 21.3(2017):451-459.

5-Bromo-2-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-nitropyridine Suppliers

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View Lastest Price from 5-Bromo-2-nitropyridine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
5-Bromo-2-nitropyridine 39856-50-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-19
WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Bromo-2-nitropyridine 39856-50-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-30
hebei hongtan Biotechnology Co., Ltd
Product
5-Bromo-2-nitropyridine 39856-50-3
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000kg
Release date
2024-05-14

39856-50-3, 5-Bromo-2-nitropyridineRelated Search:

5-Bromo-2-pyridinecarbonitrile 5-Chloro-2-bromo-3-nitropyridine 5-Bromo-2-nitropyridine 3-BROMO-5-NITROPYRIDINE,2-BROMO-5-NITROPYRIDINE ,98% 3-BROMO-2-HYDRAZINO-5-NITROPYRIDINE 3,5-DIBROMO-4-NITROPYRIDINE 2-CHLORO-3-BROMO-5-NITROPYRIDINE 4-AMINO-3-BROMO-5-NITROPYRIDINE 2,6-Dibromo-3-nitropyridine 4-BROMO-3-NITROPYRIDINE 3,5-DIBROMO-2-NITROPYRIDINE 3-AMINO-5-BROMO-2-NITROPYRIDINE 2-BROMO-4-NITROPYRIDINE N-OXIDE,2-BROMO-4-NITROPYRIDINE 1-OXIDE,2-BROMO-4-NITROPYRIDINE1N-OXIDE 3-BROMO-4-NITROPYRIDINE,3-BROMO-4-NITROPYRIDINE 97% 2-BROMO-4-NITROPYRIDINE 2-Methoxy-3-Bromo-5-Nitropyridine 2-Amino-3-bromo-5-nitropyridine 98%,2-AMINO-3-BROMO-5-NITROPYRIDINE 2,3-DIBROMO-5-NITRO PYRIDINE

  • AKOS BBS-00001330
  • 2-NITRO-5-BROMOPYRIDINE
  • 5-BROMO-2-NITROPYRIDINE
  • 3-BROMO-6-NITROPYRIDINE
  • 2-NITRO-5-BROMO PYRIDINE(5-BROMO-2-NITROPYRIDINE)
  • 5-BROMO-2-NITROPYRIDINE, 98+%
  • 3-Bromo-6-nitropyridine (5-Bromo-2-nitropyridine)
  • 5-Bromo-2-notropyridine
  • 5-Bromo-2-nitropyrid
  • 5-BroMo-2-nitropyridine, 99% 1GR
  • Pyridine, 5-broMo-2-nitro-
  • 2-Nitro-5-borMopyridine
  • 2-Nitro-5-broMopyridine, 98%, 98%
  • 2 - nitro - 5 - broMide pyridine
  • Palbociclib impurity A
  • 5-Bromo-2-nitropyridine 99%
  • 5-Bromo-2-nitropyridine &gt
  • 5-Bromo-2-nitropyridine ISO 9001：2015 REACH
  • 39856-50-3 5-Bromo-2-nitropyridine
  • 5-BROMO-2-NITROPYRIDINE Extra Pure
  • 39856-50-3
  • 39586-50-3
  • 2-NITRO-5-BROMO
  • 851607-56-6
  • C5H3N2O2Br
  • Pyridines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Bromopyridines
  • Halopyridines
  • Building Blocks
  • Heterocycle-Pyridine series
  • blocks
  • Bromides
  • Pyridines
  • Pyridine
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Organohalides
  • Bromopyridines
  • Halopyridines
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines derivates
  • 39856-50-3