Metrizoic acid

ChemicalBook > CAS DataBase List > Metrizoic acid

Product Name: Metrizoic acid
CAS No.: 1949-45-7
Chemical Name: Metrizoic acid
Synonyms: Metrizoic;metrizoate;Triosil-280;METRIZOIC ACID;MetrizoicAcid>Metrizoic acid USP/EP/BP;3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido);3,5-DiacetaMido-N-Methyl-2,4,6-triiodobenzoic Acid;3-acetamido-2,4,6-triiodo-5-N-methylacetamidobenzoic acid;3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)-benzoicaci
CBNumber: CB1775662
Molecular Formula: C12H11I3N2O4
Formula Weight: 627.94
MOL File: 1949-45-7.mol

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Metrizoic acid Property

Melting point:: 281-282°
Boiling point:: 678.8±55.0 °C(Predicted)
Density: 2.3140 (estimate)
storage temp.: 2-8°C(protect from light)
solubility: DMSO
form: Solid
pka: 0.82±0.10(Predicted)
color: White
Merck: 14,6156
CAS DataBase Reference: 1949-45-7(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo- (1949-45-7)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
RTECS: DG0887300
HS Code: 2924.29.7790

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M1363
Product name: Metrizoic Acid
Purity: >98.0%(T)(HPLC)
Packaging: 5g
Price: $31
Updated: 2024/03/01

TCI Chemical

Product number: M1363
Product name: Metrizoic Acid
Purity: >98.0%(T)(HPLC)
Packaging: 25g
Price: $59
Updated: 2024/03/01

TRC

Product number: M338935
Product name: Metrizoic Acid
Packaging: 10g
Price: $950
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 41633
Product name: Metrizoic Acid
Packaging: 10g
Price: $1460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0030393
Product name: METRIZOIC ACID
Purity: 95.00%
Packaging: 10G
Price: $2148.3
Updated: 2021/12/16

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Metrizoic acid Chemical Properties,Usage,Production

Originator

Isopaque,Winthrop,France,1973

Uses

Diagnosis aid (radiopaque medium).

Definition

ChEBI: Metrizoic acid is a monocarboxylic acid. It has a role as a radioopaque medium.

Manufacturing Process

3,5-Diacetamido-2,4,6-triiodobenzoic acid (diatrizoic acid) (see Diatrizoate entry for synthesis) (10 g) is suspended in water (10 ml), 5 N potassium hydroxide (4.3 equivalent) is added and the mixture cooled to about 15°C. Dimethyl sulfate (0.5 equivalent) dissolved in an equal volume of acetone is added drop by drop while stirring. After the reaction mixture has been stirred for about 1 hour hydrochloric acid (1:1) is added, with stirring to pH about 0.5. The precipitate is filtered, washed and suspended moist in 4 parts of water, concentrated ammonia is added to pH about 7 and the ammonium salt solution is isomerized at 90°C to 100°C for about one-half hour whereafter additional ammonia is added to pH about 9 followed by solid ammonium chloride (about 10% weight/volume) and the solution stirred overnight and the excess of 3,5-diacetamide-2,4,6-triiodobenzoic acid recovered as ammonium salt on the filter. The filtrate is precipitated by means of hydrochloric acid (1:1 ) at pH about 0.5 and the N-methyl-3,5-diacetamido- 2,4,6-triiodobenzoic acid collected on a filter, washed and dried.

Therapeutic Function

Diagnostic aid (radiopaque medium)

Metrizoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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METRIZOIC ACID

3-ACETAMIDO-5-(N-METHYLACETAMIDO)-2,4,6-TRIIODOBENZOIC ACID

3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo-benzoicaci

3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)-benzoicaci

metrizoate

3-acetamido-2,4,6-triiodo-5-N-methylacetamidobenzoic acid

3-(Acetylamino)-5-[acetyl methyl-amino)2,4,6-triiodobenzoic acid

Metrizoic

3-Acetylamino-5-(N-methylacetylamino)-2,4,6-triiodobenzoic acid

Triosil-280

3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoic acid

3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodo-benzoic acid

3-acetamido-5-[ethanoyl(methyl)amino]-2,4,6-triiodo-benzoic acid

3,5-DiacetaMido-N-Methyl-2,4,6-triiodobenzoic Acid

3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido)

MetrizoicAcid&gt

Benzoic acid, 3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo-

Metrizoic acid USP/EP/BP

1949-45-7

C12H11I3N2O4

Amines

Aromatics

Diagnostic

Intermediates & Fine Chemicals

Pharmaceuticals