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2-Cyano-5-bromomethylpyridine

Product Name
2-Cyano-5-bromomethylpyridine
CAS No.
308846-06-2
Chemical Name
2-Cyano-5-bromomethylpyridine
Synonyms
2-Cyano-5-bromomethylpyridine;5-(bromomethyl)picolinonitrile;2-cyano-5-broMide-Methyl pyridine;5-(broMoMethyl)-2-pyridinecarbonitrile;5-(BROMOMETHYL)PYRIDINE-2-CARBONITRILE;2-Pyridinecarbonitrile, 5-(broMoMethyl)-;2-Cyano-5-bromomethylpyridine ISO 9001：2015 REACH;5-(Bromomethyl)-2-cyanopyridine, 5-(Bromomethyl)picolinonitrile
CBNumber
CB1837870
Molecular Formula
C7H5BrN2
Formula Weight
197.03
MOL File
308846-06-2.mol
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2-Cyano-5-bromomethylpyridine Property

Boiling point:
329.5±32.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.23±0.10(Predicted)
Appearance
Light brown to brown Solid
InChI
InChI=1S/C7H5BrN2/c8-3-6-1-2-7(4-9)10-5-6/h1-2,5H,3H2
InChIKey
VEPVNICICSNYPW-UHFFFAOYSA-N
SMILES
C1(C#N)=NC=C(CBr)C=C1
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B682138
Product name
5-(Bromomethyl)pyridine-2-carbonitrile
Packaging
250mg
Price
$175
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-9-X3
Product name
5-(Bromomethyl)pyridine-2-carbonitrile
Packaging
250mg
Price
$176
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148587
Product name
5-(Bromomethyl)pyridine-2-carbonitrile
Packaging
250mg
Price
$587.5
Updated
2021/12/16
Activate Scientific
Product number
AS16363
Product name
2-Cyano-5-bromomethylpyridine
Purity
95+%
Packaging
1g
Price
$237
Updated
2021/12/16
Apolloscientific
Product number
OR60075
Product name
5-(Bromomethyl)pyridine-2-carbonitrile
Packaging
1g
Price
$247
Updated
2021/12/16
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2-Cyano-5-bromomethylpyridine Chemical Properties,Usage,Production

Synthesis

1620-77-5

308846-06-2

General procedure for the synthesis of 5-(bromomethyl)-2-cyanopyridine using 2-cyano-5-methylpyridine as starting material: commercially available 2-cyano-5-methylpyridine (1.90 g, 16.1 mmol) was dissolved in chloroform (100 mL), followed by the addition of N-bromosuccinimide (4.29 g, 24.1 mmol) and α,α-azobisisobutyronitrile (0.792 g, 4.82 mmol). The reaction mixture was stirred at 60 °C for 6 hours. After completion of the reaction, the mixture was cooled in an ice bath, the precipitate was separated by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to afford the target compound 5-(bromomethyl)-2-cyanopyridine (1.69 g, 53% yield).1H NMR (CDCl3) δ (ppm): 4.80 (s, 2H), 8.03 (dd, J = 0.92, 8.07 Hz, 1H), 8.12 (dd, J = 2.20, 8.07 Hz. 1H), 8.81 (d, J = 1.83 Hz, 1H).

References

[1] Patent: EP2163554, 2010, A1. Location in patent: Page/Page column 52-53
[2] Patent: WO2007/28083, 2007, A2. Location in patent: Page/Page column 69-70
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 7, p. 1017 - 1022
[4] Journal of Medicinal Chemistry, 2003, vol. 46, # 17, p. 3612 - 3622
[5] Patent: WO2011/20615, 2011, A1. Location in patent: Page/Page column 57; 58

2-Cyano-5-bromomethylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Cyano-5-bromomethylpyridine Suppliers

Canada 1 China 77 India 1 United Kingdom 4 United States 9 Global 92
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Advanced Chemical Intermediates Ltd.
Tel
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Fax
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Email
enquiries@acints.com
Country
United Kingdom
ProdList
418
Advantage
50
Atlantic Research Chemicals Ltd.
Tel
--
Fax
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Email
info@atlantic-chemicals.com
Country
United Kingdom
ProdList
5618
Advantage
63
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View Lastest Price from 2-Cyano-5-bromomethylpyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Cyano-5-bromomethylpyridine 308846-06-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Career Henan Chemical Co
Product
2-Cyano-5-bromomethylpyridine 308846-06-2
Price
US $7.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
JD724
Release date
2019-09-02

308846-06-2, 2-Cyano-5-bromomethylpyridineRelated Search:

5-Bromo-2-methylpyridine 5-Bromo-2-pyridinecarbonitrile 2,4,6-Collidine 2-Picoline 4-Methylpyridine p-Tolunitrile Chlorfenapyr 1-Hexadecylpyridinium bromide Trimethylsilyl cyanide 2-Cyano-5-nitropyridine 2-Chloro-3-cyanopyridine 2-Cyano-5-fluoropyridine 3-Amino-6-cyanopyridine 2-Cyanopyridine 2,6-Lutidine Azamethiphos 3-CYANO-5-METHYLPYRIDINE DBDCB

  • 5-(BROMOMETHYL)PYRIDINE-2-CARBONITRILE
  • 5-(Bromomethyl)-2-cyanopyridine, 5-(Bromomethyl)picolinonitrile
  • 2-cyano-5-broMide-Methyl pyridine
  • 5-(broMoMethyl)-2-pyridinecarbonitrile
  • 2-Pyridinecarbonitrile, 5-(broMoMethyl)-
  • 2-Cyano-5-bromomethylpyridine
  • 5-(bromomethyl)picolinonitrile
  • 2-Cyano-5-bromomethylpyridine ISO 9001：2015 REACH
  • 308846-06-2
  • Methyl Halides
  • Methyl Halides
  • Pyridines