GW441756

ChemicalBook > CAS DataBase List > GW441756

Product Name: GW441756
CAS No.: 504433-23-2
Chemical Name: GW441756
Synonyms: Gw;CS-1085;W 441756;GW441758;GW 441756;GW441756, >98%;GW441756 USP/EP/BP;GW 441756; GW-441756;3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one;-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
CBNumber: CB1839809
Molecular Formula: C17H13N3O
Formula Weight: 275.3
MOL File: 504433-23-2.mol

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GW441756 Property

Boiling point:: 568.0±50.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble in DMSO (up to 5 mg/ml).
pka: 11.04±0.20(Predicted)
form: solid
color: Orange
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16915
Product name: GW 441756
Purity: ≥95%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 16915
Product name: GW 441756
Purity: ≥95%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 16915
Product name: GW 441756
Purity: ≥95%
Packaging: 10mg
Price: $113
Updated: 2024/03/01

Tocris

Product number: 2238
Product name: GW441756
Purity: ≥99%(HPLC)
Packaging: 50
Price: $927
Updated: 2021/12/16

Tocris

Product number: 2238
Product name: GW441756
Purity: ≥99%(HPLC)
Packaging: 10
Price: $221
Updated: 2021/12/16

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GW441756 Chemical Properties,Usage,Production

Description

GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM).

Uses

GW 441756 is an effective Trk binder, a novel bioactive molecule used in the treatment of neuroblastoma in infants.

Definition

ChEBI: 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one is a member of indoles.

Biological Activity

Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC 50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.

storage

Store at RT

References

1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14 953 2) Takemoto et al. (2015) Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury; Environ. Toxicol. Pharmacol. 40 199 [Focus Citation]

GW441756 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GW441756 manufacturers

Career Henan Chemical Co

Product: GW441756 504433-23-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

504433-23-2, GW441756Related Search:

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1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE

GW 441756

2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-

(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one

-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one

3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one

3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-1H-PYRROLO[3,2-B]PYRIDIN-2-ONE;HYDROCHLORIDE

GW 441756; GW-441756

CS-1085

GW441756, >98%

W 441756

GW441756 USP/EP/BP

3-((1-methyl-1H-indol-3-yl)methylene)-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

GW441758

504433-23-2

504433-23-3

Angiogenesis and Metastasis

Inhibitors