GW441756
- Product Name
- GW441756
- CAS No.
- 504433-23-2
- Chemical Name
- GW441756
- Synonyms
- Gw;CS-1085;W 441756;GW441758;GW 441756;GW441756, >98%;GW441756 USP/EP/BP;GW 441756; GW-441756;3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one;-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
- CBNumber
- CB1839809
- Molecular Formula
- C17H13N3O
- Formula Weight
- 275.3
- MOL File
- 504433-23-2.mol
GW441756 Property
- Boiling point:
- 568.0±50.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble in DMSO (up to 5 mg/ml).
- pka
- 11.04±0.20(Predicted)
- form
- solid
- color
- Orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16915
- Product name
- GW 441756
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 16915
- Product name
- GW 441756
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 16915
- Product name
- GW 441756
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 2238
- Product name
- GW441756
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $927
- Updated
- 2021/12/16
- Product number
- 2238
- Product name
- GW441756
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $221
- Updated
- 2021/12/16
GW441756 Chemical Properties,Usage,Production
Description
GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM).
Uses
GW 441756 is an effective Trk binder, a novel bioactive molecule used in the treatment of neuroblastoma in infants.
Definition
ChEBI: 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one is a member of indoles.
Biological Activity
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC 50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.
storage
Store at RT
References
1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14 953 2) Takemoto et al. (2015) Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury; Environ. Toxicol. Pharmacol. 40 199 [Focus Citation]
GW441756 Preparation Products And Raw materials
Raw materials
Preparation Products
GW441756 Suppliers
View Lastest Price from GW441756 manufacturers
- Product
- GW441756 504433-23-2
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23