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GW441756

Product Name
GW441756
CAS No.
504433-23-2
Chemical Name
GW441756
Synonyms
Gw;CS-1085;W 441756;GW441758;GW 441756;GW441756, >98%;GW441756 USP/EP/BP;GW 441756/GW 441758;GW 441756; GW-441756;GW-441756 hydrochloride, TrKA receptor tyrosine kinase inhibitor
CBNumber
CB1839809
Molecular Formula
C17H13N3O
Formula Weight
275.3
MOL File
504433-23-2.mol
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GW441756 Property

Boiling point:
568.0±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Soluble in DMSO (up to 5 mg/ml).
pka
11.04±0.20(Predicted)
form 
solid
color 
Orange
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16915
Product name
GW 441756
Purity
≥95%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
16915
Product name
GW 441756
Purity
≥95%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
16915
Product name
GW 441756
Purity
≥95%
Packaging
10mg
Price
$113
Updated
2024/03/01
Tocris
Product number
2238
Product name
GW441756
Purity
≥99%(HPLC)
Packaging
50
Price
$927
Updated
2021/12/16
Tocris
Product number
2238
Product name
GW441756
Purity
≥99%(HPLC)
Packaging
10
Price
$221
Updated
2021/12/16
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GW441756 Chemical Properties,Usage,Production

Description

GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM).

Uses

GW 441756 is an effective Trk binder, a novel bioactive molecule used in the treatment of neuroblastoma in infants.

Definition

ChEBI: 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one is a member of indoles.

Biological Activity

Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC 50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.

storage

Store at RT

References

1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14 953 2) Takemoto et al. (2015) Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury; Environ. Toxicol. Pharmacol. 40 199 [Focus Citation]

GW441756 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW441756 Suppliers

China 99 Europe 1 Germany 2 India 2 The Netherlands 1 United Kingdom 2 United States 22 Global 129
ACTIVATE SCIENTIFIC GmbH
Tel
--
Fax
--
Email
info@activate-scientific.com
Country
Germany
ProdList
2856
Advantage
61
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from GW441756 manufacturers

Career Henan Chemical Co
Product
GW441756 504433-23-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

504433-23-2, GW441756Related Search:

QNZ (EVP4593) Bosutinib PF 573228 BAY 87-2243 Raltitrexed Tie2 kinase inhibitor GW284543 GW788388 GW9662 GW5074 GW 284543 hydrochloride - UNC 10225170 hydrochloride 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine GW9508 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- 1756-L71 1756-OF4 GW441756 1,3-Dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

  • 1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE
  • GW 441756
  • Gw
  • 2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-
  • (Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
  • -3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
  • 3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one
  • 3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-1H-PYRROLO[3,2-B]PYRIDIN-2-ONE;HYDROCHLORIDE
  • GW 441756; GW-441756
  • CS-1085
  • GW441756, >98%
  • W 441756
  • GW441756 USP/EP/BP
  • 3-((1-methyl-1H-indol-3-yl)methylene)-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one
  • GW441758
  • GW-441756 hydrochloride, TrKA receptor tyrosine kinase inhibitor
  • GW 441756/GW 441758
  • 504433-23-2
  • 504433-23-3
  • Angiogenesis and Metastasis
  • Inhibitors