Fumaryl chloride Property

Melting point:

-2 °C

Boiling point:

161-164 °C(lit.)

Density 

1.415 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.499(lit.)

Flash point:

165 °F

storage temp. 

2-8°C

form 

Liquid

color 

Clear yellow

Specific Gravity

1.415 (20/4℃)

Water Solubility 

decomposes

Sensitive 

Moisture Sensitive

BRN 

1721342

InChIKey

ZLYYJUJDFKGVKB-OWOJBTEDSA-N

CAS DataBase Reference

627-63-4(CAS DataBase Reference)

NIST Chemistry Reference

Fumaryl chloride(627-63-4)

EPA Substance Registry System

2-Butenedioyl dichloride, (2E)- (627-63-4)

Safety

Hazard Codes 

C

Risk Statements 

20/21/22-34-37-29-36/37-14

Safety Statements 

26-36/37/39-45-8-27

RIDADR 

UN 1780 8/PG 2

WGK Germany 

3

RTECS 

LT2800000

F 

21

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29171990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Fumaryl chloride Chemical Properties,Usage,Production

Chemical Properties

Clear yellow liquid

Uses

Chemical intermediate for pharmaceuticals, dyestuffs, and insecticides.

Uses

Fumaryl chloride was used in the preparation of high molecular weight poly(propylene fumarate). The photodissociation dynamics of fumaryl chloride was studied. It is used in agrochemicals and pharmaceuticals manufacturing. Also used as an intermediate for dyes, textile auxiliaries and peroxide compounds. It is an acid halide building block.

Preparation

Fumaryl chloride has been prepared from fumaric acid and phthaloyl chloride, from maleic acid by the action of thionyl chloride in the presence of zinc chloride, and from maleic anhydride by the use of phthaloyl chloride in the presence of zinc chloride.
Org. Synth. 1940, 20, 51
DOI: 10.15227/orgsyn.020.0051

General Description

Fumaryl chloride appears as a straw colored fuming liquid with a pungent odor. Vapors irritate the eyes and mucous membranes. Corrosive to metals and tissue.

Reactivity Profile

Fumaryl chloride is incompatible with strong oxidizing agents, alcohols, amines and other bases. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Hazard

Corrosive to eyes and skin.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Safety Profile

Moderately toxic by ingestion, inhalation, and skin contact. A skin, eye, and mucous membrane irritant. A corrosive agent. Will react with water or steam to produce toxic and corrosive fumes. When heated to decomposition it emits highly toxic fumes of phosgene and HCl.