ChemicalBook > CAS DataBase List > Cefoselis
Cefoselis
- Product Name
- Cefoselis
- CAS No.
- 122841-10-5
- Chemical Name
- Cefoselis
- Synonyms
- cefoselis;Cefoselis USP/EP/BP;(6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[2-(2-hydroxyethyl)-3-iminopyrazol-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl]methyl]-8-oxo-, (6R,7R)-
- CBNumber
- CB1855261
- Molecular Formula
- C19H22N8O6S2
- Formula Weight
- 522.56
- MOL File
- 122841-10-5.mol
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Cefoselis Property
- Density
- 1.83±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 2.77±0.50(Predicted)
- CAS DataBase Reference
- 122841-10-5(CAS DataBase Reference)
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N-Bromosuccinimide Price
ApexBio Technology
- Product number
- B1074
- Product name
- Cefoselis
- Packaging
- 5mg
- Price
- $153
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B1074
- Product name
- Cefoselis
- Packaging
- 10mg
- Price
- $246
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B1074
- Product name
- Cefoselis
- Packaging
- 50mg
- Price
- $633
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0005603
- Product name
- CEFOSELIS
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $909.56
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B1074
- Product name
- Cefoselis
- Packaging
- 100mg
- Price
- $1012
- Updated
- 2021/12/16
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Cefoselis Chemical Properties,Usage,Production
Description
Cefotaxime (cefoselis, FK037) is a fourth-generation cephalosporin. Compared with the commonly used third-generation cephalosporins, it has a wider antibacterial spectrum and has enhanced effects on AmpCβ-lactamase-producing Enterobacteriaceae bacteria.
Uses
Cefoselis can inhibit the cross-linking of mucinous peptide chains in the process of cell wall synthesis, so that bacteria cannot form a complete cell wall; eventually induce sensitive bacteria to form filaments, so that the bacteria eventually dissolve and die.
Biological Activity
cefoselis is a widely used antibiotic of β-lactam [1].cefoselis has a large antibacterial spectrum against gram positive bacterium. it is a 4th generation of cephalosporin. cefoselis has some side effects, such as inducing seizures and convulsion in elder and renal failure patients. through testing the dialysate and blood samples by hplc, it shows that cefoselis appears in the striatal dialysate samples does-dependently and disappears rapidly from the extracellular fluid. in renal failure rats, the elimination half-lives of cefoselis are prolonged. it may be one factor of the seizures caused by cefoselis. in addition, administration of cefoselis into the hippocampus causes highly increase of extracellular glutamate and slightly increase of gaba, suggesting that cefoselis induces seizures through blocking the gaba receptors [1].
target
β-lactam
References
[1] ohtaki k, matsubara k, fujimaru s, shimizu k, awaya t, suno m, chiba k, hayase n, shiono h. cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. j neural transm. 2004 dec;111(12):1523-35.
Cefoselis Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cefoselis manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- Cefoselis 122841-10-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 300 MT
- Release date
- 2020-05-23
Career Henan Chemical Co
- Product
- Cefoselis 122841-10-5
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-01-08
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