ChemicalBook > CAS DataBase List > Cefoselis

Cefoselis

Product Name
Cefoselis
CAS No.
122841-10-5
Chemical Name
Cefoselis
Synonyms
cefoselis;Cefoselis USP/EP/BP;(6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[2-(2-hydroxyethyl)-3-iminopyrazol-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl]methyl]-8-oxo-, (6R,7R)-
CBNumber
CB1855261
Molecular Formula
C19H22N8O6S2
Formula Weight
522.56
MOL File
122841-10-5.mol
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Cefoselis Property

Density 
1.83±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
2.77±0.50(Predicted)
CAS DataBase Reference
122841-10-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B1074
Product name
Cefoselis
Packaging
5mg
Price
$153
Updated
2021/12/16
ApexBio Technology
Product number
B1074
Product name
Cefoselis
Packaging
10mg
Price
$246
Updated
2021/12/16
ApexBio Technology
Product number
B1074
Product name
Cefoselis
Packaging
50mg
Price
$633
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005603
Product name
CEFOSELIS
Purity
95.00%
Packaging
1G
Price
$909.56
Updated
2021/12/16
ApexBio Technology
Product number
B1074
Product name
Cefoselis
Packaging
100mg
Price
$1012
Updated
2021/12/16
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Cefoselis Chemical Properties,Usage,Production

Description

Cefotaxime (cefoselis, FK037) is a fourth-generation cephalosporin. Compared with the commonly used third-generation cephalosporins, it has a wider antibacterial spectrum and has enhanced effects on AmpCβ-lactamase-producing Enterobacteriaceae bacteria.

Uses

Cefoselis can inhibit the cross-linking of mucinous peptide chains in the process of cell wall synthesis, so that bacteria cannot form a complete cell wall; eventually induce sensitive bacteria to form filaments, so that the bacteria eventually dissolve and die.

Biological Activity

cefoselis is a widely used antibiotic of β-lactam [1].cefoselis has a large antibacterial spectrum against gram positive bacterium. it is a 4th generation of cephalosporin. cefoselis has some side effects, such as inducing seizures and convulsion in elder and renal failure patients. through testing the dialysate and blood samples by hplc, it shows that cefoselis appears in the striatal dialysate samples does-dependently and disappears rapidly from the extracellular fluid. in renal failure rats, the elimination half-lives of cefoselis are prolonged. it may be one factor of the seizures caused by cefoselis. in addition, administration of cefoselis into the hippocampus causes highly increase of extracellular glutamate and slightly increase of gaba, suggesting that cefoselis induces seizures through blocking the gaba receptors [1].

target

β-lactam

References

[1] ohtaki k, matsubara k, fujimaru s, shimizu k, awaya t, suno m, chiba k, hayase n, shiono h. cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. j neural transm. 2004 dec;111(12):1523-35.

Cefoselis Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cefoselis manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Cefoselis 122841-10-5
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
300 MT
Release date
2020-05-23
Career Henan Chemical Co
Product
Cefoselis 122841-10-5
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-01-08

122841-10-5, CefoselisRelated Search:


  • cefoselis
  • (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[[2-(2-hydroxyethyl)-3-iminopyrazol-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl]methyl]-8-oxo-, (6R,7R)-
  • Cefoselis USP/EP/BP
  • 122841-10-5
  • C19H22N8O6S2