cis-4-Hydroxy-D-proline hydrochloride
Uses Synthetic Application- Product Name
- cis-4-Hydroxy-D-proline hydrochloride
- CAS No.
- 77449-94-6
- Chemical Name
- cis-4-Hydroxy-D-proline hydrochloride
- Synonyms
- cis-D-Hyp-OH.HCl;H-D-cis-Hyp-OH.HCL;Cis-4-OH-D-pro-OH·HCl;CIS-4-HYDROXY-D-PROLINE HCL;D-Proline, 4-hydroxy-,hydrochloride;cis-4-Hydroxy-D-proline hydrochloride;cis-4-Hydro×y-D-proline hydrochloride;(2R,4R)-4-hydroxyproline hydrochloride;D-Proline, 4-hydroxy-,hydrochloride (1:1);Cis-4-hydroxy-D-proline monohydrochloride
- CBNumber
- CB1947559
- Molecular Formula
- C5H10ClNO3
- Formula Weight
- 167.5908
- MOL File
- 77449-94-6.mol
cis-4-Hydroxy-D-proline hydrochloride Property
- Melting point:
- 114-116 °C
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/s3
- InChIKey
- YEJFFQAGTXBSTI-QYDODFSFNA-N
- SMILES
- C(O)(=O)[C@H]1C[C@@H](O)CN1.[H]Cl |&1:3,5,r|
Safety
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H952393
- Product name
- Cis-4-Hydroxy-D-prolinehydrochloride
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 074556
- Product name
- cis-4-Hydroxy-D-proline hydrochloride
- Purity
- 95+%
- Packaging
- 5g
- Price
- $121
- Updated
- 2021/12/16
- Product number
- 4H58-5-4C
- Product name
- cis-4-Hydroxy-D-proline hydrochloride
- Purity
- 97.0%
- Packaging
- 5G
- Price
- $130
- Updated
- 2021/12/16
- Product number
- J96651
- Product name
- cis-4-Hydroxy-D-prolinehydrochloride
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 4H58-5-4C
- Product name
- cis-4-Hydroxy-D-proline hydrochloride
- Purity
- 97.0%
- Packaging
- 25g
- Price
- $190
- Updated
- 2021/12/16
cis-4-Hydroxy-D-proline hydrochloride Chemical Properties,Usage,Production
Uses
Cis-4-Hydroxy-D-proline belongs to the class of organic compounds known as proline and derivatives. Proline and derivatives are compounds containing proline or a derivative thereof resulting from a reaction of proline at the amino group or the carboxyl group, or from the replacement of any hydrogen of glycine by a heteroatom. cis-4-Hydroxy-D-proline is a substrate that may be used to study the specificity and kinetics of D-alanine dehydrogenase.
Synthetic Application
Cis-4-Hydroxy-D-proline may be used as a starting material for the 13-step synthesis of new conformationally restricted PNA adenine monomer and the synthesis of N-Benzyl pyrrolidinyl sordaricin derivatives. Cis-4-Hydroxy-D-proline is a substrate that may be used to study the specificity and kinetics of D-alanine dehydrogenase. Cis-4-Hydroxy-D-proline may be used to analyze the substrate specificity of amino acid transporter PAT1.
Synthesis
A mixture of (2S,4R)-4-hydroxypyrrolidine-2-carboxylicacid(50 mmol, 6550 mg) and Ac2O (250 mmol, 23.5 mL) in AcOH (100 mL) wasstirred at reflux for 6 h. The resulting mixture was concentrated to give thecrude intermediate. The solution of this crude intermediate in 2 N HCl (50 mL)was stirred at reflux for 3 h. Then activated charcoal (1 g) was added, the hotmixture was ltered immediately through a Celite layer. The filtrate was concentrated in vacuo to give the crude intermediate.The crude intermediate was dissolved in acetone and filtered. The residue was washed twice with ether anddried in vacuo to give cis-4-Hydroxy-D-proline hydrochloride as a white solid (7.54 g, 90percent).
cis-4-Hydroxy-D-proline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from cis-4-Hydroxy-D-proline hydrochloride manufacturers
- Product
- cis-4-Hydroxy-D-proline hydrochloride 77449-94-6
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 97-99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-19