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Nigericin sodium salt

Product Name
Nigericin sodium salt
CAS No.
28643-80-3
Chemical Name
Nigericin sodium salt
Synonyms
Nsc292567;Helexin C;Nigerian Sodium;Sodium Nigericin;Nigericin sodiuM sa;Nigericin sodium salt;Nigericin, monosodium salt;Nigericin, sodium salt(1:1);SODIUM NIGERICIN;NSC-292567;Nigericin sodium salt USP/EP/BP
CBNumber
CB1972391
Molecular Formula
C40H69NaO11
Formula Weight
748.97
MOL File
28643-80-3.mol
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Nigericin sodium salt Property

Melting point:
approximate 255℃
storage temp. 
2-8°C
solubility 
Soluble in chloroform, methanol or ethanol
form 
solution
color 
White
Merck 
13,6569
BRN 
3892398
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey
MOYOTUKECQMGHE-NTQCAYBPSA-M
LogP
4.817 (est)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3462 6.1/PG 3
WGK Germany 
3
RTECS 
QT6840000
HazardClass 
6.1
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
481990
Product name
Nigericin sodium salt
Packaging
5mg
Price
$80.7
Updated
2023/01/07
Sigma-Aldrich
Product number
481990
Product name
Nigericin sodium salt
Packaging
10mg
Price
$129
Updated
2022/05/15
Alfa Aesar
Product number
J61349
Product name
Nigericin sodium salt, 98+%
Packaging
10mg
Price
$202
Updated
2024/03/01
Cayman Chemical
Product number
11437
Product name
Nigericin (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
11437
Product name
Nigericin (sodium salt)
Purity
≥98%
Packaging
10mg
Price
$81
Updated
2024/03/01
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Nigericin sodium salt Chemical Properties,Usage,Production

Description

Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin Na is K+> Rb+> Cs+>>Na+. Cell permeable.

Chemical Properties

NIGERICIN SODIUM SALT is white powder

Uses

Nigericin sodium is the atypical salt of nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.

Uses

Nigericin sodium is a salt of the atypical polyether antibiotic, nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.

Uses

Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

General Description

A monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H+ (antiport). Transports monovalent cations across membranes with the following specificities: K+>Rb+>Cs+>>Na+. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.

Biochem/physiol Actions

Product does not compete with ATP.

storage

Store at -20°C

References

1) Akhmedov et al. (2010), Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells; FASEB J., 24 4613 2) Gong et al. (2010), Chemical probing reveals insights into the signaling mechanism of inflammasome activation; Cell Res., 20 1289

Nigericin sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Nigericin sodium salt Suppliers

China 122 France 1 Germany 4 India 1 Switzerland 1 United Kingdom 6 United States 20 USA 1 Global 156
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
Apollo Scientific Ltd.
Tel
--
Fax
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Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Leancare Ltd.
Tel
--
Fax
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Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
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42
MOLEKULA Ltd.
Tel
--
Fax
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Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
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View Lastest Price from Nigericin sodium salt manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Nigericin sodium salt 28643-80-3
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-06-15
Hebei Mojin Biotechnology Co., Ltd
Product
Nigericin sodium salt 28643-80-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-31
Career Henan Chemical Co
Product
Nigericin sodium salt 28643-80-3
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

28643-80-3, Nigericin sodium saltRelated Search:

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  • Nigericin sodium salt, 98%, from Streptomyces hygroscopicus
  • (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt
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  • Sodium (R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-3-methyltetrahydro-2H-pyran-2-yl)propanoate
  • Sodium (R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-3-methyltetrahydro-2H-pyran-2-yl)propanoate
  • 28643-80-3
  • C40H67NaO11
  • C40H67O11Na
  • API