GF109203X

Product Name: GF109203X
CAS No.: 133052-90-1
Chemical Name: GF109203X
Synonyms: BIM 1;GO 6850;G 6850];CS-1080;Estorra;GF 109203X;GO 6850 HCL;GF-109203X HCL;RBT205 INHIBITOR;GF109203X Go-6850
CBNumber: CB2103079
Molecular Formula: C25H24N4O2
Formula Weight: 412.48
MOL File: 133052-90-1.mol

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GF109203X Property

Melting point:: 280℃ (decomposition)
Boiling point:: 685.6±55.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ~1 mg/mlsoluble
pka: 8.13±0.60(Predicted)
form: Liquid
color: Orange
Water Solubility: Insoluble in water.
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.

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Safety

Hazard Codes: Xn
Risk Statements: 40-22
Safety Statements: 36/37
WGK Germany: 3
RTECS: UX9590000
HS Code: 2925199590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 203290
Product name: Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem
Purity: A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC?? = 10 nM) that is structurally similar to staurosporine.
Packaging: 250μg
Price: $56.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 203290
Product name: Bisindolylmaleimide I
Packaging: 1mg
Price: $187
Updated: 2024/03/01

TCI Chemical

Product number: B5781
Product name: Bisindolylmaleimide I
Packaging: 5MG
Price: $95
Updated: 2024/03/01

TCI Chemical

Product number: B5781
Product name: Bisindolylmaleimide I
Packaging: 25MG
Price: $330
Updated: 2024/03/01

Alfa Aesar

Product number: J63401
Product name: Bisindolylmaleimide 1
Packaging: 5mg
Price: $153.65
Updated: 2024/03/01

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GF109203X Chemical Properties,Usage,Production

Description

GF-109203X (133052-90-1) is a potent and selective protein kinase C inhibitor (IC50 = 10 nM; cAMP-dependent protein kinase IC50 = 2 μM and phosphorylase kinase IC50 = 0.7 μM). Inactive against the tyrosine kinases EGFR, PGDFR and Insulin receptor. Potent inhibitor of GSK-3β in cell lysates (IC50 = 360nM) and GSK-3β immunoprecipitates (IC50 = 170nM) derived from rat epididymal adipocytes.2 Cell permeable.

Uses

Bisindolylmaleimide is used as a highly selective inhibitor of all PKC isoforms and slight inhibitor of GSK-3, used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals, very potent and selective inhibitor of protein kinase C.

Biological Activity

Very potent and selective inhibitor of protein kinase C, selective for the α and β 1 isoforms (IC 50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μ M for α , β 1, δ , ε , and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC 50 values are 0.6, 4.6, and 33 μ M respectively). Potent antagonist at the 5-HT 3 receptor (K i = 29.5 nM). Anti-inflammatory in vivo . Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.

storage

Store at RT

References

1) Toullec, et al. (1991), The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol .Chem. 266 15771 2) Hers, et al. (1999) The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity; FEBS Lett. 460 433

GF109203X Preparation Products And Raw materials

Raw materials

Preparation Products

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GF109203X Suppliers

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View Lastest Price from GF109203X manufacturers

Career Henan Chemical Co

Product: GF109203X 133052-90-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-14

133052-90-1, GF109203XRelated Search:

Bisindolylmaleimide I (GF 109203X)

InSolution? Bisindolylmaleimide I

GO 6850

GO 6850 HCL

GF 109203X

GF-109203X HCL

GF109203X HYDROCHLORIDE

BISINDOLYLMALEIMIDE

BISINDOLYLMALEIMIDE I

BISINDOLYLMALEIMIDE I HYDROCHLORIDE

BISINDOYLMALEIMIDE

2-(1-(3-DIMETHYLAMINOPROPYL)-INDOL-3-YL)-3-(INDOL-3-YL)MALEIMIDE

2-[1-(3-DIMETHYLAMINOPROPYL)-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)-MALEIMIDE

2-[1-(3-DIMETHYLAMINOPROPYL)-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)MALEIMIDE, HCL

3-[1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2 ,5-DIONE

3-(N-[DIMETHYLAMINO]PROPYL-3-INDOLYL)-4-(3-INDOLYL)MALEIMIDE

BisindolylmaleimideGF 109203X

Bisindolylmaleinimide

2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide,hydrochloride

1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-

Bisindolylmaleimide 2-(1-(3-Dimethylaminopropyl)-indol-3-yl)-3-(indol-3-yl)maleimide

3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, Bisindolylmaleimide I, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione

3-[1-[3-(DiMethylaMino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrol-2,5-dione

BisindolylMaleiMide I (free base) [GF-109203X

G 6850]

BIM 1

CS-1080

RBT205 INHIBITOR

InSolution Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem

Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem

BISINDOLYLMALEIMIDE I;GO 6850

GF109203X USP/EP/BP

Estorra

GF109203X Go-6850

133052-90-1

C25H24N4O2HCl

C25H24N4O2

C27H26N4O2

Cell Signaling and Neuroscience

Cell Biology

Biochemicals and Reagents

BioChemical

Enzymes, Inhibitors, and Substrates

Serine/Threonine Kinase Inhibitors

Protein Kinase Inhibitors and Related Products

Protein Kinase C and Glycogen Synthase Kinase 3 (PKC & GSK3)

Protein Kinases and Phosphatases

Kinase/Phosphatase Biology

TGF-beta/Smad

Inhibitors

Smad

TGF-beta

Protein Kinase

inhibitor