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MRS 2578

Product Name
MRS 2578
CAS No.
711019-86-2
Chemical Name
MRS 2578
Synonyms
CS-1109;MRS 2578;MRS-2578; MRS2578;MRS 2578 USP/EP/BP;MRS 2578 >=95% (HPLC);MRS 2578;MRS-2578; MRS2578;MRS2578 P2Y6 antagonist MRS-2578;1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE;N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA];1,1'-(Butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
CBNumber
CB2112787
Molecular Formula
C20H20N6S4
Formula Weight
472.67
MOL File
711019-86-2.mol
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MRS 2578 Property

Melting point:
170 - 173°C
Boiling point:
652.7±65.0 °C(Predicted)
Density 
1.31
storage temp. 
2-8°C
solubility 
DMSO: ~17 mg/mL
form 
solid
pka
11.80±0.70(Predicted)
color 
white
InChIKey
QOHNRGHTJPFMSL-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-42
Safety Statements 
22-26-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M0319
Product name
MRS 2578
Purity
≥95% (HPLC)
Packaging
5mg
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
M0319
Product name
MRS 2578
Purity
≥95% (HPLC)
Packaging
25mg
Price
$572
Updated
2024/03/01
Cayman Chemical
Product number
19704
Product name
MRS 2578
Purity
≥98%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19704
Product name
MRS 2578
Purity
≥98%
Packaging
10mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
19704
Product name
MRS 2578
Purity
≥98%
Packaging
25mg
Price
$183
Updated
2024/03/01
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MRS 2578 Chemical Properties,Usage,Production

Description

MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6.

Uses

MRS 2578 has been used an antagonist of purinoceptor P2Y6:

  • to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
  • in P. aeruginosa infected mice to test its effect on the inflammatory responses
  • to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes

Uses

MRS 2578 is a selective P2Y66?receptor antagonist.

Biological Activity

Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

Biochem/physiol Actions

MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.

storage

-20°C (desiccate)

References

[1] mamedova l k, joshi b v, gao z g, et al. diisothiocyanate derivatives as potent, insurmountable antagonists of p2y6 nucleotide receptors[j]. biochemical pharmacology, 2004, 67(9): 1763-1770.

MRS 2578 Preparation Products And Raw materials

Raw materials

Preparation Products

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MRS 2578 Suppliers

China 72 Germany 1 Switzerland 1 United Kingdom 2 United States 17 Global 93
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from MRS 2578 manufacturers

Career Henan Chemical Co
Product
MRS 2578 711019-86-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1ton
Release date
2020-01-10

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  • N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA]
  • MRS 2578
  • 1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE
  • N',N'''-butane-1,4-diylbis[1-(3-isothiocyanatophenyl)(thiourea)]
  • Thiourea, N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)-
  • MRS 2578;MRS-2578; MRS2578
  • MRS-2578; MRS2578
  • CS-1109
  • Thiourea, N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)- (9CI)
  • MRS 2578 >=95% (HPLC)
  • MRS 2578 USP/EP/BP
  • 1,1'-(Butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
  • MRS2578 P2Y6 antagonist MRS-2578
  • 1,1'-(Butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
  • 711019-86-2
  • C20H20N6S4
  • Inhibitors