ChemicalBook > CAS DataBase List > 4-BROMO-2-HYDROXYACETOPHENONE

4-BROMO-2-HYDROXYACETOPHENONE

Product Name
4-BROMO-2-HYDROXYACETOPHENONE
CAS No.
30186-18-6
Chemical Name
4-BROMO-2-HYDROXYACETOPHENONE
Synonyms
1-(4-Bromo-2-hydroxyphenyl)ethan-1-one;2-Acetyl-5-bromophenol;1-(4-Bromo-2-hydroxyphenyL;4-BROMO-2-HYDROXYACETOPHENONE;4'-Bromo-2'-hydroxyacetophenone;4-Bromo-2-hydroxyacetophenone ,97%;4'-Bromo-2'-hydroxyacetophenone,95%;4'-Bromo-2'-hydroxyacetophenone 98%;1-(4-BROMO-2-HYDROXY-PHENYL)-ETHANONE;ETHANONE, 1-(4-BROMO-2-HYDROXYPHENYL)-
CBNumber
CB2154233
Molecular Formula
C8H7BrO2
Formula Weight
215.04
MOL File
30186-18-6.mol
More
Less

4-BROMO-2-HYDROXYACETOPHENONE Property

Melting point:
40.0 to 44.0 °C
Boiling point:
83°C/7mmHg(lit.)
Density 
1.586±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
Solid
pka
9.20±0.10(Predicted)
color 
White to Yellow to Orange
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C8H7BrO2/c1-5(10)7-3-2-6(9)4-8(7)11/h2-4,11H,1H3
InChIKey
LQCMMXGKEGWUIM-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC=C(Br)C=C1O)C
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
RIDADR 
1759
HS Code 
29143990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B5382
Product name
4'-Bromo-2'-hydroxyacetophenone
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$22
Updated
2025/07/31
TCI Chemical
Product number
B5382
Product name
4'-Bromo-2'-hydroxyacetophenone
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$65
Updated
2025/07/31
TRC
Product number
B696240
Product name
1-(4-Bromo-2-hydroxyphenyl)ethanone
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B696240
Product name
1-(4-Bromo-2-hydroxyphenyl)ethanone
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
074747
Product name
1-(4-Bromo-2-hydroxyphenyl)ethanone
Purity
95+%
Packaging
1g
Price
$10
Updated
2021/12/16
More
Less

4-BROMO-2-HYDROXYACETOPHENONE Chemical Properties,Usage,Production

Chemical Properties

White to yellow solid

Uses

4'-Bromo-2'-hydroxyacetophenone is used as a pharmaceutical intermediate.

Preparation

Preparation by diazotization of 5-amino-3-bromo-2- hydroxyacetophenone, followed by hydrolysis of the obtained diazonium salt (51%).

Synthesis

35065-86-2

30186-18-6

General procedure for the synthesis of 1-(4-bromo-2-hydroxyphenyl)ethanone from phenyl 3-bromoacetate: In a round-bottomed flask equipped with a reflux condenser, a nitrogen inlet, and a sodium hydroxide solution, aluminum chloride (36 g, 270 mmol) was slowly added to intermediate 9A (32.0 g, 149 mmol) to absorb the HCl gas generated. Water was generated during the reaction. The reaction flask was heated in an oil bath at 120°C. The reaction mixture gradually became fluid and was then slowly warmed to 165°C over a period of 1 hour and held at this temperature for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature. Approximately 200 mL of dichloromethane was added to the solid reaction mixture to form a slurry. The slurry was slowly poured into ice, a process that needed to be repeated several times to ensure complete treatment of the reaction mixture. The dichloromethane/water mixture was stirred until both phases became fairly clear, followed by phase separation. The organic phase was washed with brine, dried over anhydrous magnesium sulfate and finally concentrated under vacuum to give Intermediate 9B (30.14 g, 140 mmol, 94% yield) as a dark red oil. Mass spectrum (ESI) m/z 213,215.3 (M + H)+. The purity of the product was about 90%.

References

[1] Patent: US2009/202478, 2009, A1
[2] Patent: WO2007/37187, 2007, A1. Location in patent: Page/Page column 137
[3] Patent: WO2008/79836, 2008, A2. Location in patent: Page/Page column 96-97
[4] Synthesis (Germany), 2017, vol. 49, # 9, p. 1983 - 1992
[5] MedChemComm, 2013, vol. 4, # 11, p. 1434 - 1438

4-BROMO-2-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Acetic anhydride Acetyl chloride Triethylamine Aluminum chloride Diethyl ether Ethyl acetate Hydrochloric acid Dichloromethane Pyridine Magnesium sulfate 3-Bromophenol

Preparation Products

More
Less

4-BROMO-2-HYDROXYACETOPHENONE Suppliers

Americas 1 China 185 Europe 1 Germany 2 India 3 Japan 1 United Kingdom 5 United States 19 Global 217
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Mianyang Chemget Chemical Co., Ltd.
Tel
816-816-2551723 18681628050
Fax
08162551905
Email
sales@chemget.com.cn
Country
China
ProdList
101
Advantage
58
Suzhou Vosun Biotech Co.,Ltd
Tel
18934576691
Fax
0512-82177265
Email
yq@vosunbio.com
Country
China
ProdList
735
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
ZEROSCHEM.CO.,LTD.
Tel
10-61256048 13810278579
Fax
+86 10 61256049
Email
sales@zeroschem.com
Country
China
ProdList
1370
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Shanghai ZaiQi Bio-Tech Co., Ltd.
Tel
021-54824098, 021-37212705 021-37212706, 13391256916
Fax
021-54824069
Email
sales@chemzq.com
Country
China
ProdList
570
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Ascepion Pharmaceuticals, Inc.
Tel
+86-512-86881668
Fax
+86-512-62956001
Country
China
ProdList
100
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ShangHai D&B Biological Science and Technology Co.Ltd
Tel
400-008-9730,021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3057
Advantage
60
Hangzhou Dechem Tech Co.，Ltd
Tel
86-0571-87649320
Fax
86-0571-87649320
Email
dechem@aliyun.com
Country
China
ProdList
162
Advantage
58
Chemfun Medical Technology(Shanghai) Co., Ltd.
Tel
021-67220633 021-54824098
Fax
+86-21-54824069
Email
chemfun@chemfun.net
Country
China
ProdList
491
Advantage
58
Jiaxing Novartis Chemical Co., Ltd.
Tel
18957373295
Fax
-
Country
China
ProdList
1580
Advantage
58
Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.
Tel
19943855286
Fax
0371-53392065
Email
triz-4@trizpharma.cn
Country
China
ProdList
1936
Advantage
56
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Jiangsu Mingchem Corporation
Tel
0519-85170101
Fax
0519-85170505
Email
sales@mingchem.com
Country
China
ProdList
608
Advantage
55
Changzhou Anxuan Chemical, Co., Ltd.
Tel
13912302692 13912302692;
Fax
0519-88064678
Email
sales@anxuanchem.com
Country
China
ProdList
4828
Advantage
58
Struchem Co., Ltd.
Tel
0512-63009836 18994340901
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3981
Advantage
60
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
Shanghai PharmaPartner Co., Ltd.
Tel
19983777532
Fax
-
Email
pharmabridge@163.com
Country
China
ProdList
501
Advantage
55
AOKBIO Inc.
Tel
021-68712331 3286104197
Fax
021 68712331
Country
China
ProdList
322
Advantage
55
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
More
Less

View Lastest Price from 4-BROMO-2-HYDROXYACETOPHENONE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-BROMO-2-HYDROXYACETOPHENONE 30186-18-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Shaanxi Dideu Medichem Co. Ltd
Product
4-BROMO-2-HYDROXYACETOPHENONE 30186-18-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-07-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-BROMO-2-HYDROXYACETOPHENONE 30186-18-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

30186-18-6, 4-BROMO-2-HYDROXYACETOPHENONERelated Search:

5-BroMo-2-hydroxy-4-Methylacetophenone w-Bromo-4-Hydroxyacetophenone,OMEGA-BROMO-4-HYDROXYACETOPHENONE 5-Bromo-2-hydroxyacetophenone 2'-BROMO-4'-HYDROXYACETOPHENONE,2-BROMO-4'-HYDROXYACETOPHENONE,ALPHA-BROMO-4-HYDROXYACETOPHENONE,α-Bromo-4-hydroxyacetophenone,2-Bromo-4-Hydroxyacetophenone98% Disperse Blue 56 7-bromochroman-4-one 4-BROMO-2-HYDROXYACETOPHENONE Disperse Blue 81 1-Amino-2-bromo-4-hydroxy-9,10-anthraquinone 7-Bromo-4-oxo-4H-chromene-3-carbaldehyde 2-Bromo-2′-hydroxyacetophenone 4'-BROMO-2-HYDROXYACETOPHENONE 3',5'-Dibromo-4'-hydroxyacetophenone 3',5'-Dibromo-2'-hydroxyacetophenone 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE 4'-Bromoacetophenone 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE N-BOC-7-BROMO-4-OXO-3,4-DIHYDRO-1''H-SPIRO[CHROMENE-2,4''-PIPERIDINE]

  • ETHANONE, 1-(4-BROMO-2-HYDROXYPHENYL)-
  • 4-BROMO-2-HYDROXYACETOPHENONE
  • 1-(4-BROMO-2-HYDROXY-PHENYL)-ETHANONE
  • 1-(4-Bromo-2-hydroxyphenyl)ethan-1-one
  • 4-Bromo-2-hydroxyacetophenone ,97%
  • 1-(4-Bromo-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-5-bromophenol
  • 4'-Bromo-2'-hydroxyacetophenone 98%
  • 1-(4-Bromo-2-hydroxyphenyL
  • 4'-Bromo-2'-hydroxyacetophenone,95%
  • 2-Acetyl-5-bromophenol
  • 4'-Bromo-2'-hydroxyacetophenone
  • 30186-18-6
  • Aromatic Acetophenones & Derivatives (substituted)