4-BROMO-2-HYDROXYACETOPHENONE

Product Name: 4-BROMO-2-HYDROXYACETOPHENONE
CAS No.: 30186-18-6
Chemical Name: 4-BROMO-2-HYDROXYACETOPHENONE
Synonyms: 1-(4-Bromo-2-hydroxyphenyl)ethan-1-one;2-Acetyl-5-bromophenol;1-(4-Bromo-2-hydroxyphenyL;4-BROMO-2-HYDROXYACETOPHENONE;4'-Bromo-2'-hydroxyacetophenone;4-Bromo-2-hydroxyacetophenone ,97%;4'-Bromo-2'-hydroxyacetophenone,95%;4'-Bromo-2'-hydroxyacetophenone 98%;1-(4-BROMO-2-HYDROXY-PHENYL)-ETHANONE;ETHANONE, 1-(4-BROMO-2-HYDROXYPHENYL)-
CBNumber: CB2154233
Molecular Formula: C8H7BrO2
Formula Weight: 215.04
MOL File: 30186-18-6.mol

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4-BROMO-2-HYDROXYACETOPHENONE Property

Melting point:: 40.0 to 44.0 °C
Boiling point:: 83°C/7mmHg(lit.)
Density: 1.586±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: Solid
pka: 9.20±0.10(Predicted)
color: White to Yellow to Orange
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C8H7BrO2/c1-5(10)7-3-2-6(9)4-8(7)11/h2-4,11H,1H3
InChIKey: LQCMMXGKEGWUIM-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(Br)C=C1O)C

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
RIDADR: 1759
HS Code: 29143990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5382
Product name: 4'-Bromo-2'-hydroxyacetophenone
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: B5382
Product name: 4'-Bromo-2'-hydroxyacetophenone
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $65
Updated: 2025/07/31

TRC

Product number: B696240
Product name: 1-(4-Bromo-2-hydroxyphenyl)ethanone
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B696240
Product name: 1-(4-Bromo-2-hydroxyphenyl)ethanone
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 074747
Product name: 1-(4-Bromo-2-hydroxyphenyl)ethanone
Purity: 95+%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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4-BROMO-2-HYDROXYACETOPHENONE Chemical Properties,Usage,Production

Chemical Properties

White to yellow solid

Uses

4'-Bromo-2'-hydroxyacetophenone is used as a pharmaceutical intermediate.

Preparation

Preparation by diazotization of 5-amino-3-bromo-2- hydroxyacetophenone, followed by hydrolysis of the obtained diazonium salt (51%).

Synthesis

35065-86-2

30186-18-6

General procedure for the synthesis of 1-(4-bromo-2-hydroxyphenyl)ethanone from phenyl 3-bromoacetate: In a round-bottomed flask equipped with a reflux condenser, a nitrogen inlet, and a sodium hydroxide solution, aluminum chloride (36 g, 270 mmol) was slowly added to intermediate 9A (32.0 g, 149 mmol) to absorb the HCl gas generated. Water was generated during the reaction. The reaction flask was heated in an oil bath at 120°C. The reaction mixture gradually became fluid and was then slowly warmed to 165°C over a period of 1 hour and held at this temperature for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature. Approximately 200 mL of dichloromethane was added to the solid reaction mixture to form a slurry. The slurry was slowly poured into ice, a process that needed to be repeated several times to ensure complete treatment of the reaction mixture. The dichloromethane/water mixture was stirred until both phases became fairly clear, followed by phase separation. The organic phase was washed with brine, dried over anhydrous magnesium sulfate and finally concentrated under vacuum to give Intermediate 9B (30.14 g, 140 mmol, 94% yield) as a dark red oil. Mass spectrum (ESI) m/z 213,215.3 (M + H)+. The purity of the product was about 90%.

References

[1] Patent: US2009/202478, 2009, A1
[2] Patent: WO2007/37187, 2007, A1. Location in patent: Page/Page column 137
[3] Patent: WO2008/79836, 2008, A2. Location in patent: Page/Page column 96-97
[4] Synthesis (Germany), 2017, vol. 49, # 9, p. 1983 - 1992
[5] MedChemComm, 2013, vol. 4, # 11, p. 1434 - 1438

4-BROMO-2-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Acetic anhydride Acetyl chloride Triethylamine Aluminum chloride Diethyl ether Ethyl acetate Hydrochloric acid Dichloromethane Pyridine Magnesium sulfate 3-Bromophenol

Preparation Products

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4-BROMO-2-HYDROXYACETOPHENONE Suppliers

Americas 1 China 185 Europe 1 Germany 2 India 3 Japan 1 United Kingdom 5 United States 19 Global 217

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

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View Lastest Price from 4-BROMO-2-HYDROXYACETOPHENONE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-BROMO-2-HYDROXYACETOPHENONE 30186-18-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Shaanxi Dideu Medichem Co. Ltd

Product: 4-BROMO-2-HYDROXYACETOPHENONE 30186-18-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-BROMO-2-HYDROXYACETOPHENONE 30186-18-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

30186-18-6, 4-BROMO-2-HYDROXYACETOPHENONERelated Search:

5-BroMo-2-hydroxy-4-Methylacetophenone w-Bromo-4-Hydroxyacetophenone,OMEGA-BROMO-4-HYDROXYACETOPHENONE 5-Bromo-2-hydroxyacetophenone 2'-BROMO-4'-HYDROXYACETOPHENONE,2-BROMO-4'-HYDROXYACETOPHENONE,ALPHA-BROMO-4-HYDROXYACETOPHENONE,α-Bromo-4-hydroxyacetophenone,2-Bromo-4-Hydroxyacetophenone98% Disperse Blue 56 7-bromochroman-4-one 4-BROMO-2-HYDROXYACETOPHENONE Disperse Blue 81 1-Amino-2-bromo-4-hydroxy-9,10-anthraquinone 7-Bromo-4-oxo-4H-chromene-3-carbaldehyde 2-Bromo-2′-hydroxyacetophenone 4'-BROMO-2-HYDROXYACETOPHENONE 3',5'-Dibromo-4'-hydroxyacetophenone 3',5'-Dibromo-2'-hydroxyacetophenone 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE 4'-Bromoacetophenone 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE N-BOC-7-BROMO-4-OXO-3,4-DIHYDRO-1''H-SPIRO[CHROMENE-2,4''-PIPERIDINE]

ETHANONE, 1-(4-BROMO-2-HYDROXYPHENYL)-

4-BROMO-2-HYDROXYACETOPHENONE

1-(4-BROMO-2-HYDROXY-PHENYL)-ETHANONE

1-(4-Bromo-2-hydroxyphenyl)ethan-1-one

4-Bromo-2-hydroxyacetophenone ,97%

1-(4-Bromo-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-5-bromophenol

4'-Bromo-2'-hydroxyacetophenone 98%

1-(4-Bromo-2-hydroxyphenyL

4'-Bromo-2'-hydroxyacetophenone,95%

2-Acetyl-5-bromophenol

4'-Bromo-2'-hydroxyacetophenone

30186-18-6

Aromatic Acetophenones & Derivatives (substituted)