ChemicalBook > CAS DataBase List > Benzimidazole

Benzimidazole

Product Name
Benzimidazole
CAS No.
51-17-2
Chemical Name
Benzimidazole
Synonyms
1H-BENZO[D]IMIDAZOLE;1H-BENZIMIDAZOLE;Benzimidazol;BZI;Benzoimidazole;3-Azaindole;Benziminazole;1H-Benzoimidazole;nsc759;Azindol
CBNumber
CB2177003
Molecular Formula
C7H6N2
Formula Weight
118.14
MOL File
51-17-2.mol
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Benzimidazole Property

Melting point:
169-171 °C (lit.)
Boiling point:
360 °C
Density 
1.1151 (rough estimate)
refractive index 
1.5500 (estimate)
Flash point:
360°C
storage temp. 
Store below +30°C.
solubility 
xylene: soluble1g in 2g (boiling)(lit.)
form 
Crystalline Powder or Crystals
pka
5.532(at 25℃)
color 
Beige to brown
Water Solubility 
sparingly soluble
λmax
271nm(MeOH)(lit.)
Merck 
14,1081
BRN 
109682
Stability:
Stable. Combustible. Incompatible with strong oxidising agents.
InChIKey
HYZJCKYKOHLVJF-UHFFFAOYSA-N
LogP
1.320
CAS DataBase Reference
51-17-2(CAS DataBase Reference)
NIST Chemistry Reference
1H-Benzimidazole(51-17-2)
EPA Substance Registry System
Benzimidazole (51-17-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-24/25
WGK Germany 
3
RTECS 
DD5425000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29339990
Hazardous Substances Data
51-17-2(Hazardous Substances Data)
Toxicity
LD50 oral in mouse: 2910mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.21956
Product name
Benzimidazole
Purity
for synthesis
Packaging
100g
Price
$64.6
Updated
2024/03/01
Sigma-Aldrich
Product number
194123
Product name
Benzimidazole
Purity
98%
Packaging
5g
Price
$76
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21956
Product name
Benzimidazole
Purity
for synthesis
Packaging
500g
Price
$249
Updated
2024/03/01
Sigma-Aldrich
Product number
194123
Product name
Benzimidazole
Purity
98%
Packaging
100g
Price
$90.9
Updated
2024/03/01
TCI Chemical
Product number
B0054
Product name
Benzimidazole
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$19
Updated
2024/03/01
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Benzimidazole Chemical Properties,Usage,Production

Chemical Properties

white crystals

Uses

Usually used as template compound in the preparation of molecularly imprinted polymer via electropolymerization and electrodeposition of pyrrole on a pencil graphite electrode,and also used in the preparation of benzimidazolium surfactant, 1-hexadecyl-1H-benzimidazole.

Uses

Benzimidazole is a building block for making anthelmintic drugs like albendazole, mebendazole and triclabendazole and anti-ulcer drugs like pantoprazole, rabeprazole, lansoprazole and omeprazole. It is used in the preparation of pyrene derived benzimidazole linked polymers (BILPs), which are used for selective carbon dioxide separation applications due to their properties like porous materials, regenerability and sorbent selection parameters.

Definition

ChEBI: 1H-benzimidazole is the 1H-tautomer of benzimidazole. It is a benzimidazole and a polycyclic heteroarene. It is a conjugate acid of a benzimidazolide. It is a tautomer of a 4H-benzimidazole, a 2H-benzimidazole and a 3aH-benzimidazole.

General Description

White tabular crystals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

An amine. Neutralizes acids to form salts plus water. These acid-base reactions are exothermic. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. May be shock sensitive.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzimidazole emits highly toxic fumes.

Fire Hazard

Flash point data for Benzimidazole are not available. Benzimidazole is probably combustible.

Pharmacology

The mode of action of benzimidazoles has been described in several comprehensive reviews (1,32,33). The primary mode of action of benzimidazoles has been identified as the specific binding to the β-subunit of fungal tubulin and, consequently, an interference with microtubule assembly. Microtubules are major components of the fungal cytoskeleton and are involved in meiosis and mitosis, both of which are blocked in the presence of benzimidazoles.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits highly toxic fumes of NOx.

Purification Methods

It crystallises from water or aqueous EtOH (charcoal) and is dried at 100o for 12hours. [Beilstein 23 H 131, 23/6 V 196.]

Benzimidazole Preparation Products And Raw materials

Raw materials

o-Phenylenediamine

Preparation Products

4,5-Imidazoledicarboxylic acid 2-Acetylbenzimidazole Thiabendazole Butyl 2-[[3-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-hydroxy-1-naphthyl]azo]benzoate Pigment Red 175 Oxatomide Imidazole Omeprazole Domperidone
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Benzimidazole Suppliers

Americas 1 Belgium 4 China 504 Czech Republic 2 Europe 4 France 2 Germany 16 Hungary 1 India 55 Indonesia 1 Japan 9 Russia 1 Slovakia 1 South Korea 3 Switzerland 4 The Netherlands 1 Ukraine 1 United Kingdom 16 United States 76 USA 1 Global 703
GLR Innovations
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View Lastest Price from Benzimidazole manufacturers

Hebei Longbang Technology Co., Ltd
Product
Benzimidazole 51-17-2
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-05-29
Watson Biotechnology Co.,Ltd
Product
Benzimidazole 51-17-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-08-27
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Benzimidazole 51-17-2
Price
US $75.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-28

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