NO-ASPIRIN 1

Product Name: NO-ASPIRIN 1
CAS No.: 175033-36-0
Chemical Name: NO-ASPIRIN 1
Synonyms: C102148;NCX 4016;nitroaspirin;NO-ASPIRIN 1;Nitroaspirin, 10 mM in DMSO;Nitric oxide-releasing aspirin;3-(NitroxyMethyl)phenyl 2-acetoxybenzoate;[3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate;2-Acetoxybenzoate-2-(1-nitroxymethyl)phenyl ester;2-AcetyloxybenzoicAcid3-NitrooxymethylphenylEster
CBNumber: CB2179315
Molecular Formula: C16H13NO7
Formula Weight: 331.28
MOL File: 175033-36-0.mol

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NO-ASPIRIN 1 Property

Melting point:: 61-62°C
Boiling point:: 499.3±40.0 °C(Predicted)
Density: 1.347±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1669
Product name: NCX 4016
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $111
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1669
Product name: NCX 4016
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $312.9
Updated: 2025/07/31

TRC

Product number: N633000
Product name: NO-Aspirin1
Packaging: 50mg
Price: $265
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003519
Product name: [3-(NITROOXYMETHYL)PHENYL] 2-ACETYLOXYBENZOATE
Purity: 95.00%
Packaging: 10MG
Price: $292.95
Updated: 2021/12/16

ChemScene

Product number: CS-0086219
Product name: Nitroaspirin
Packaging: 10mg
Price: $500
Updated: 2021/12/16

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NO-ASPIRIN 1 Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4].

Definition

ChEBI: 2-acetyloxybenzoic acid [3-(nitrooxymethyl)phenyl] ester is a carbonyl compound.

Biological Activity

NCX 4016 (nitroaspirin) is nitroderivative of aspirin th at combines cyclooxygenase inhibitor with an NO donor. NCX 4016 improves postischemic ventricular dysfunction and to reduce myocardial infarct size in rabbit.', 'NCX-4016 can prevent the progression of cisplatin-resistant human ovarian cancer xenografts in mice. It can also regulate the expression of B-cell lymphoma 2 (Bcl-2) proteins in ovarian cancer cells. Hence, NCX-4016 is considered a promising therapeutic option against carcinoma.

IC 50

COX-1

References

[1] Bertuglia S, et al. Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheekpouch microcirculation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G437-43. DOI:10.1152/ajpgi.00339.2003
[2] Corazzi T, et al. Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7. DOI:10.1124/jpet.105.089896
[3] Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8. DOI:10.4161/cc.7.1.5103

NO-ASPIRIN 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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NO-ASPIRIN 1 Suppliers

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175033-36-0, NO-ASPIRIN 1Related Search:

p-Tolualdehyde 3-Phenylpropionic acid Ethylparaben p-Toluic acid Benzenesulfonic acid NO-ASPIRIN 1 2-METHOXY-BENZOIC ACID PHENYL ESTER Acetylsalicylic acid ACETYLSALICYLIC ACID METHYL ESTER Phenyl salicylate

2-(ACETYLOXY)-3-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID

NCX 4016

NO-ASPIRIN 1

2-AcetyloxybenzoicAcid3-NitrooxymethylphenylEster

nitroaspirin

[3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate

3-(NitroxyMethyl)phenyl 2-acetoxybenzoate

2-Acetoxybenzoate-2-(1-nitroxymethyl)phenyl ester

C102148

Nitric oxide-releasing aspirin

Inhibitor,Cyclooxygenase,Nitroaspirin,inhibit,NCX4016,NCX-4016,COX,Apoptosis

Benzoic acid, 2-(acetyloxy)-, 3-[(nitrooxy)methyl]phenyl ester

Nitroaspirin, 10 mM in DMSO

175033-36-0

Intermediates & Fine Chemicals

Pharmaceuticals

Aromatics Compounds

Aromatics

Inhibitors

Nitric Oxide Reagents