NO-ASPIRIN 1
- Product Name
- NO-ASPIRIN 1
- CAS No.
- 175033-36-0
- Chemical Name
- NO-ASPIRIN 1
- Synonyms
- C102148;NCX 4016;nitroaspirin;NO-ASPIRIN 1;Nitroaspirin, 10 mM in DMSO;Nitric oxide-releasing aspirin;3-(NitroxyMethyl)phenyl 2-acetoxybenzoate;[3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate;2-Acetoxybenzoate-2-(1-nitroxymethyl)phenyl ester;2-AcetyloxybenzoicAcid3-NitrooxymethylphenylEster
- CBNumber
- CB2179315
- Molecular Formula
- C16H13NO7
- Formula Weight
- 331.28
- MOL File
- 175033-36-0.mol
NO-ASPIRIN 1 Property
- Melting point:
- 61-62°C
- Boiling point:
- 499.3±40.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1669
- Product name
- NCX 4016
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $111
- Updated
- 2025/07/31
- Product number
- SML1669
- Product name
- NCX 4016
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $312.9
- Updated
- 2025/07/31
- Product number
- N633000
- Product name
- NO-Aspirin1
- Packaging
- 50mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- API0003519
- Product name
- [3-(NITROOXYMETHYL)PHENYL] 2-ACETYLOXYBENZOATE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $292.95
- Updated
- 2021/12/16
- Product number
- CS-0086219
- Product name
- Nitroaspirin
- Packaging
- 10mg
- Price
- $500
- Updated
- 2021/12/16
NO-ASPIRIN 1 Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4].
Definition
ChEBI: 2-acetyloxybenzoic acid [3-(nitrooxymethyl)phenyl] ester is a carbonyl compound.
Biological Activity
NCX 4016 (nitroaspirin) is nitroderivative of aspirin th at combines cyclooxygenase inhibitor with an NO donor. NCX 4016 improves postischemic ventricular dysfunction and to reduce myocardial infarct size in rabbit.', 'NCX-4016 can prevent the progression of cisplatin-resistant human ovarian cancer xenografts in mice. It can also regulate the expression of B-cell lymphoma 2 (Bcl-2) proteins in ovarian cancer cells. Hence, NCX-4016 is considered a promising therapeutic option against carcinoma.
IC 50
COX-1
References
[1] Bertuglia S, et al. Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheekpouch microcirculation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G437-43. DOI:10.1152/ajpgi.00339.2003
[2] Corazzi T, et al. Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7. DOI:10.1124/jpet.105.089896
[3] Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8. DOI:10.4161/cc.7.1.5103
NO-ASPIRIN 1 Preparation Products And Raw materials
Raw materials
Preparation Products
NO-ASPIRIN 1 Suppliers
- Tel
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- Fax
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- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71