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DMT-2′O-Methyl-rC(ac) Phosphoramidite

Product Name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
CAS No.
199593-09-4
Chemical Name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Synonyms
(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;Cytidine Impurity 14;2’-OMe -dC(Ac) Amidite;N4-Ac-5'-O-DMT-2'-OMe-C-CE;N4-Ac-5'-O-DMT-2'-OMe-C-CE;2'-OMe-Ac-C Phosphoramidite;2'-OMe-N-Ac CytidineAmidite;Ac-2'-Ome-rC Phosphoramidite;2'-OMe-Ac-C Phosphoramidite;2'-OMe-C(Ac) Phosphoramidite
CBNumber
CB21871625
Molecular Formula
C42H52N5O9P
Formula Weight
801.86
MOL File
199593-09-4.mol
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DMT-2′O-Methyl-rC(ac) Phosphoramidite Property

Melting point:
102 - 104°C
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
powder
pka
10.18±0.20(Predicted)
color 
white to off-white
InChI
InChI=1/C42H52N5O9P/c1-28(2)47(29(3)4)57(54-26-12-24-43)56-38-36(55-40(39(38)52-8)46-25-23-37(44-30(5)48)45-41(46)49)27-53-42(31-13-10-9-11-14-31,32-15-19-34(50-6)20-16-32)33-17-21-35(51-7)22-18-33/h9-11,13-23,25,28-29,36,38-40H,12,26-27H2,1-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,57?/s3
InChIKey
WNWUMIPFLOKTEZ-UAQIPLLRSA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,39,42,r|
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C213180
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
1G
Price
$125
Updated
2024/03/01
Sigma-Aldrich
Product number
C213100
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
100g
Price
$6540
Updated
2024/03/01
Sigma-Aldrich
Product number
C213100
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
500g
Price
$32550
Updated
2024/03/01
Sigma-Aldrich
Product number
C213180
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
0.5g
Price
$92.7
Updated
2024/03/01
Sigma-Aldrich
Product number
C213130
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
configured for ABI
Packaging
1g
Price
$84.7
Updated
2024/03/01
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DMT-2′O-Methyl-rC(ac) Phosphoramidite Chemical Properties,Usage,Production

Uses

2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.

Application

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

General Description

DMT-2′O-Methyl-rC(ac) Phosphoramidite is one of the 2′O-Methyl RNA monomers that feature methoxy groups at the 2′-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:
High yield of crude oligonucleotides
Compatible with DNA synthesis
Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

DMT-2′O-Methyl-rC(ac) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-2′O-Methyl-rC(ac) Phosphoramidite Suppliers

China 144 India 3 United Kingdom 2 United States 12 Global 161
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View Lastest Price from DMT-2′O-Methyl-rC(ac) Phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
N4-Ac-5'-O-DMT-2'-OMe-C-CE 199593-09-4
Price
US $0.00/mg
Min. Order
100mg
Purity
≥98%
Supply Ability
20tons
Release date
2023-03-09
SHANGHAI NOVRIBO BIOTECH
Product
2'-OMe-Ac-C CE Phosphoramidite 199593-09-4
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21
Henan Aochuang Chemical Co.,Ltd.
Product
N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 199593-09-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-23

199593-09-4, DMT-2′O-Methyl-rC(ac) PhosphoramiditeRelated Search:

DMT-2′O-TBDMS-rU Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite Dmt-2'-f-dc(ac) amidite N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-6'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite Ac-rC Phosphoramidite 2’-O-Methyl-rA(N-Bz)phosphoramidite 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE DMT-dG(dmf) Phosphoramidite 2'-OMe-ibu-G Phosphoramidite Acetyl coenzyme A sodium salt N-ACETYL-L-TYROSINE ETHYL ESTER Acetylacetone Acetylferrocene tributyl acetocitrate Cytidine DMT-2′O-Methyl-rC(ac) Phosphoramidite Acetyl-resveratrol

  • 2'-OMe-Ac-C Phosphoramidite
  • 2’-O-Methyl-rC(N-Ac)Phosphoramidite
  • 5'-O-DMT-2'-O-Me-rC(N-Ac)-3'-CEDPA
  • N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • (2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
  • 5'-DMT-2'-OMe-rC(N-Ac) Phosphoramidite
  • N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
  • DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • 2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite
  • -5-(4-Acetamido-2-oxopyrimidin-1(2H)
  • Ac-2'-Ome-rC Phosphoramidite
  • 2'-OMe-Ac-rC -CE Phosphoramidite
  • N4-acetyl-5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Cytidine-3'-CE-Phosphoramidite
  • 2'-OMe-Ac-C Phosphoramidite (~90%)
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 2'-OMe-C(Ac) Phosphoramidite
  • N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP
  • 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • N4-ACETYL-5-O-DMTr-2-O-METHYLCYTIDINE-3-O- CE-AMIDITE
  • 5'-O-DMT-2'-OMe-Ac-C-CE-Phosphoramidite
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • 5'-O-DMT-N4-Acetyl-2'-O-methylcytidine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite
  • DMT-2-O-ME-C-CE Phosphoramidite
  • "DMT-2'-O-Me-dC(Ac) Phosphoramidite"
  • N4-Ac-5'-O-DMT-2'-OMe-C-CE
  • DMT-2’-OMe-C(Ac)-CE Phosphoramidite
  • 2'-OMe-N-Ac Cytidine?Amidite
  • DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite
  • 2’-OMe -dC(Ac) Amidite
  • 5'-ODMT-2'-OMe-N-Ac Cytidine-3'-OCEPA
  • 2'-OMe-Ac-C Phosphoramidite
  • DMT-2'-O-Me-C(Ac)-CE Phosphoramidite
  • N4-Ac-5'-O-DMT-2'-OMe-C-CE
  • 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite
  • 2'-OMe-C(Ac)-CE-Phosphoramidite
  • 2'-OMe-Ac-C CE Phosphoramidite
  • N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 2'-OMe-rC(Ac)Phosphoramidite
  • N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
  • 2'-OMe-N-Ac CytidineAmidite
  • DMT-2'O-METHYL-RC(AC) PHOSPHORAMIDITE
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
  • Cytidine Impurity 14
  • 199593-09-4
  • C42H52N5O9P
  • Amidite