Description References
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Cilnidipine

Description References
Product Name
Cilnidipine
CAS No.
132203-70-4
Chemical Name
Cilnidipine
Synonyms
CiL;clinidipine;ATELEC;CINALONG;SISCARD;FRC-8653;Sidipine;FRG 8653;nidipine;ilnidipine
CBNumber
CB2193117
Molecular Formula
C27H28N2O7
Formula Weight
492.52
MOL File
132203-70-4.mol
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Cilnidipine Property

Melting point:
97-99°C
Boiling point:
652.6±55.0 °C(Predicted)
Density 
1.240±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: ≤2mg/mL
pka
2.61±0.70(Predicted)
form 
powder
color 
light yellow
Water Solubility 
H2O: ≤2mg/mL
DMSO: ≥20mg/mL
Merck 
14,2275
InChIKey
KJEBULYHNRNJTE-DHZHZOJOSA-N
CAS DataBase Reference
132203-70-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
41
Safety Statements 
26-39
WGK Germany 
3
RTECS 
US7975550
HS Code 
29333990
Toxicity
LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C1493
Product name
Cilnidipine
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
C1493
Product name
Cilnidipine
Purity
≥98% (HPLC), powder
Packaging
50mg
Price
$277.2
Updated
2024/03/01
TCI Chemical
Product number
C2564
Product name
Cilnidipine
Purity
>98.0%(HPLC)
Packaging
1g
Price
$95
Updated
2024/03/01
TCI Chemical
Product number
C2564
Product name
Cilnidipine
Purity
>98.0%(HPLC)
Packaging
5g
Price
$284
Updated
2024/03/01
Cayman Chemical
Product number
26080
Product name
Cilnidipine
Purity
≥98%
Packaging
500mg
Price
$68
Updated
2024/03/01
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Cilnidipine Chemical Properties,Usage,Production

Description

Clinidipine is a kind of calcium channel blocker. It is a kind of novel calcium antagonist with the blocking effect on both L-type and N-type calcium channels. It is mainly used for the treatment of hypertension. Based on its effect on both N-type and L-type calcium channel, it can dilate both arterioles and venules, further reducing the pressure in the capillary bed. In addition, cilinidipine can attenuate the platelet activation associated with catecholamines.

References

https://www.drugbank.ca/drugs/DB09232
https://en.wikipedia.org/wiki/Cilnidipine

Description

Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM. Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats. It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg. Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.

Description

Cilnidipine is a dihydropyridine calcium antagonist introduced for the treatment of essential and severe hypertension and hypertension associated with renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for long-term treatment, due to its characteristics of slow onset and long duration with less cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity. It may also be useful in ischemic heart disease.

Chemical Properties

Yellow Crystalline Solid

Originator

Fujirebio (Japan)

Uses

A dihydropyridine calcium channel blocker.

Uses

antihypertensive;dihydropyridine calcium channel blocker

Uses

Cilnidipine has been used:

  • in cell viability assay of pheochromocytoma (nPC12) cells
  • in photoirradiation and photodegradation studies
  • to understand effect on albuminuria in diabetic nephropathy

Definition

ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.

brand name

Cinalong;Siscard;Atelec

Biological Activity

Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Biochem/physiol Actions

Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

storage

+4°C

Cilnidipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate

Preparation Products

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Cilnidipine Suppliers

Americas 1 Belgium 2 Brazil 1 Canada 5 China 312 China Hong Kong 1 Europe 3 France 2 Germany 4 India 56 Japan 8 South Korea 3 Spain 1 The Netherlands 1 United Kingdom 21 United States 59 Global 480
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View Lastest Price from Cilnidipine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cilnidipine 132203-70-4
Price
US $0.00/g
Min. Order
100g
Purity
98%
Supply Ability
200kg/month
Release date
2021-07-20
Hebei Weibang Biotechnology Co., Ltd
Product
Cilnidipine 132203-70-4
Price
US $1.00-1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10mt
Release date
2024-11-11
Hangzhou ICH Biofarm Co., Ltd
Product
Cilnidipine 132203-70-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0% min
Supply Ability
1000kgs/month
Release date
2023-06-12

132203-70-4, CilnidipineRelated Search:

4-Methoxybenzylchloride N,N-Dimethylformamide Dimethyl sulfoxide Dimethyl carbonate Anisole Dimethyl fumarate Dimethyl sulfate Dimethyl disulfide ETHANE Dimethyl phthalate 4-(Trifluoromethoxy)aniline Octyl 4-methoxycinnamate Dimethyl ether p-Anisaldehyde p-Anisidine (Trifluoromethoxy)benzene Dacthal Cilnidipine Impurity 2

  • ATELEC
  • (+/-)-(e)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
  • O3-(2-Methoxyethyl) O5-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-(2-methoxyethyl)5-[(E)-3-phenyl-2-propenyl] ester
  • 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-(2-methoxyethyl)5-[(E)-3-phenyl-2-propenyl] ester
  • Frc 8653,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • ilnidipine
  • 3-CinnaMyl 5-(2-Methoxyethyl) 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 3-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylat
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL (2E)-3-PHENYL-2-PROPENYL ESTER
  • SISCARD
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester
  • 3-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxy
  • CINALONG
  • CILNIDIPINE
  • FRC-8653
  • 2,6-dimethyl-4-(3-nitrophenyl)-5-(3-phenylprop-2-enoxymethyl)-1,4-dihydropyridine-3-carboxylic acid 2-methoxyethyl ester
  • Sidipine
  • Cilnidipine (FRC-8653)
  • Cilnidipine Whatsapp
  • CILNDIPINE
  • (e)-(+-)-ethoxyethyl3-phenyl-2-propenyleste
  • 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2-m
  • Cinildipine
  • CINILDPINE
  • Cinidipine
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester, FRC-8653, Atelec, Cinalong, Siscard,
  • CILNIDPINE
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-
  • clinidipine
  • FRG 8653
  • Cilnidipine and intermediates
  • Cilnidipine &gt
  • Cilnidipine RS
  • CiL
  • nidipine
  • 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • Cilnidipine USP/EP/BP
  • Cilnidipine D4
  • CilnidipineQ: What is Cilnidipine Q: What is the CAS Number of Cilnidipine Q: What is the storage condition of Cilnidipine
  • Cilinidipine
  • Cilnidipine, ≥ 98.0%
  • Cilnidipine, Dual L- and N-type Ca2+ channel blocker
  • Cilnidipine, 10 mM in DMSO
  • 132203-70-4
  • Dihydropyridine Class Chemicals
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Calcium channel
  • API
  • FRC 8653
  • Dihydropyridine
  • APIs
  • Active Pharmaceutical Ingredients
  • 132203-70-4