ChemicalBook > CAS DataBase List > 4-Hydroxy-L-isoleucine

4-Hydroxy-L-isoleucine

Product Name: 4-Hydroxy-L-isoleucine
CAS No.: 781658-23-9
Chemical Name: 4-Hydroxy-L-isoleucine
Synonyms: Hydroxy L-isoleucine;4-HYDROXY-L-ISOLEUCINE;L-4- hydroxyl isoleucine;L-Isoleucine, 4-hydroxy-;4-Hydroxyisoleucine (1327319);4-Hydroxy-L-isoleucine;4-Hydroxy-L-isoleucine USP/EP/BP;4-Hydroxyisoleucine, 10 mM in DMSO;(4S)-4-Hydroxy-L-isoleucine from fenugre;(2S,3R)-2-aMino-4-hydroxy-3-Methylpentanoic acid
CBNumber: CB22130042
Molecular Formula: C6H13NO3
Formula Weight: 147.17
MOL File: 781658-23-9.mol

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4-Hydroxy-L-isoleucine Property

Melting point:: >200°
Boiling point:: 332 ºC
Density: 1.181
Flash point:: 147 ºC
storage temp.: 2-8°C
pka: 2.41±0.25(Predicted)
form: powder
color: White
optical activity: [α]/D +34.0±2.0°, c = 1 in H2O
Water Solubility: Soluble in water
InChIKey: OSCCDBFHNMXNME-UHFFFAOYSA-N
CAS DataBase Reference: 781658-23-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2922505000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 49549
Product name: 4-Hydroxy-L-isoleucine
Purity: ≥98.0% (TLC)
Packaging: 10mg
Price: $59.99
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1327319
Product name: 4-Hydroxyisoleucine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 35mg
Price: $416
Updated: 2025/07/31

Sigma-Aldrich

Product number: 49549
Product name: 4-Hydroxy-L-isoleucine
Purity: ≥98.0% (TLC)
Packaging: 50mg
Price: $328
Updated: 2025/07/31

Usbiological

Product number: 293661
Product name: 4-Hydroxy-L-isoleucine
Packaging: 10mg
Price: $333
Updated: 2021/12/16

Usbiological

Product number: H9090-72
Product name: 4-Hydroxyisoleucine
Packaging: 10mg
Price: $375
Updated: 2021/12/16

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4-Hydroxy-L-isoleucine Chemical Properties,Usage,Production

Chemical Properties

4-Hydroxyisoleucine is Light Yellow Solid

Uses

4-Hydroxy-L-isoleucine is used as a treatment for type II diabetes.

Definition

ChEBI: 4-Hydroxy-L-isoleucine is an isoleucine derivative.

Biochem/physiol Actions

A peculiar amino acid extracted from fenugreek seeds and never found in mammalian tissues, exhibits interesting insulinotropic activity; effects on insulin secretion, plant-derived treatment for metabolic syndrome.

in vivo

4-Hydroxyisoleucine (50 mg/kg, p.o., daily, 8 weeks) inhibits the increase in serum glucose in the fructose-fed rat model of metabolic syndrome^[1]. 4-Hydroxyisoleucine (200 mg/kg, p.o., 8 weeks) improves dyslipidemia and reduces lipid ectopic accumulation in C57BL/6 mice^[4].
4-Hydroxyisoleucine (200 mg/kg, p.o., 8 weeks) decreases the expression of proinflammatory cytokine (IL-6, PAI-1, IL-1β, NF-κB, TNF-α, and MCP-1) and the proportion of proinflammatory M1 macrophages in C57BL/6 mice^[4].
4-Hydroxyisoleucine (50 mg/kg, i.g., daily, 14 days) restores high levels of lipids (cholesterol, HDL, LDL and triglycerides) and uric acid in type 1 diabetic rat to that of nondiabetic controls level^[5].

Animal Model:	Fructose-fed rat^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage (p.o.), daily, 8 weeks
Result:	Decreased the levels of glucose and ALT. Reduced 80% of fructosehe-induced AST release to 151 ± 45 U/mL.

Animal Model:	Type 2 diabetic rat^[1]
Dosage:	50 mg/kg
Administration:	i.g., daily, 14 days
Result:	Restored the level of HDL-cholesterol to levels comparable to controls.

Animal Model:	Male C57BL/6 mice^[4]
Dosage:	50-200 mg/kg
Administration:	Oral gavage (p.o.), 8 weeks
Result:	Decreases the body weights of mice in a dose-dependent manner. Decreased blood glucose levels and fasting plasma insulin content in mice. Decreased the expression of TLR4, inhibited the phosphorylation of JNK, and increased the production of IκB-α.

Animal Model:	Type 1 diabetic rat^[5]
Dosage:	50 mg/kg
Administration:	i.g., daily, 14 days
Result:	Improved appearance and heavy ocular vascularization. Reduced the blood glucose from 500 mg/dl to 330 mg/dl. Decreased the levels of lipid markers (TG, LDL and HDL) and uric acid. Didn’t increase the level of inculin compared with untreated diabetic controls.

4-Hydroxy-L-isoleucine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Hydroxy-L-isoleucine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Hydroxy-L-isoleucine 781658-23-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

R&D Scientific Inc.

Product: 4-Hydroxy-L-isoleucine 781658-23-9
Price: US $1090.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-03-31

Shanghai Standard Technology Co., Ltd.

Product: 4-Hydroxyisoleucine 781658-23-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-16

781658-23-9, 4-Hydroxy-L-isoleucineRelated Search:

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4-HYDROXY-L-ISOLEUCINE

(2S,3R)-2-aMino-4-hydroxy-3-Methylpentanoic acid

L-4- hydroxyl isoleucine

(4S)-4-Hydroxy-L-isoleucine from fenugre

L-Isoleucine, 4-hydroxy-

4-Hydroxy-L-isoleucine USP/EP/BP

4-Hydroxyisoleucine (1327319)

Hydroxy L-isoleucine

4-Hydroxyisoleucine, 10 mM in DMSO

4-Hydroxy-<sc>L</sc>-isoleucine

781658-23-9

217-86-9

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