Proparacaine hydrochloride

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Proparacaine hydrochloride

Product Name: Proparacaine hydrochloride
CAS No.: 5875-06-9
Chemical Name: Proparacaine hydrochloride
Synonyms: alcaine;ophthain;keracaine;ophthetic;PROPARACAINE HCL;chibro-heracaine;Proparacaine HCI;Proparacaine HydrochL;ophthainehydrochloride;PROPARACAINE HYDROCHLORIDE
CBNumber: CB2242028
Molecular Formula: C16H27ClN2O3
Formula Weight: 330.85
MOL File: 5875-06-9.mol

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Proparacaine hydrochloride Property

Melting point:: 182.0-183.3°
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol, Water
form: Solid
pka: 3.2(at 25℃)
color: White to Off-White
λmax: 300nm(MeOH)(lit.)
Merck: 14,7807
InChI: InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
InChIKey: BFUUJUGQJUTPAF-UHFFFAOYSA-N
SMILES: C(OCCN(CC)CC)(=O)C1=CC=C(OCCC)C(N)=C1.[H]Cl
CAS DataBase Reference: 5875-06-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36-43
Safety Statements: 26-36
WGK Germany: 3
RTECS: DG3065000
HS Code: 2922504500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2156
Product name: Proparacaine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $72
Updated: 2024/03/01

TCI Chemical

Product number: P2156
Product name: Proparacaine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $237
Updated: 2024/03/01

TRC

Product number: P761800
Product name: Proparacaine Hydrochloride
Packaging: 500mg
Price: $275
Updated: 2021/12/16

TRC

Product number: P761800
Product name: Proparacaine Hydrochloride
Packaging: 50mg
Price: $95
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003948
Product name: PROPARACAINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $721.88
Updated: 2021/12/16

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Proparacaine hydrochloride Chemical Properties,Usage,Production

Description

Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.

Uses

Topical anesthetic (ophthalmic); Neuronal conductance inhibitor.

brand name

Alcaine (Alcon); Ophthetic (Allergan); Paracaine (Optopics).

Clinical Use

Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice.

Side effects

Occasional temporary stinging, burning and conjunctival redness may occur with the use of proparacaine. A rare, severe, immediate-type, apparently hyperallergic corneal reaction characterized by acute, intense and diffuse epithelial keratitis, a gray, ground glass appearance, sloughing of large areas of necrotic epithelium, corneal filaments and sometimes iritis with descemetitis has been reported. Allergic contact dermatitis from proparacaine with drying and fissuring of the fingertips has been reported.

Mode of action

The mechanism of action of proparacaine hydrochloride is to reduce the instantaneous permeability of neurons to sodium, stabilize the nerve cell membrane, and prevent the generation and conduction of nerve electrical impulses, thereby producing anesthesia.Likely inhibits epithelial voltage gated sodium channels like other local anesthetics.

References

1. Identification, synthesis and structural confirmation of process-related impurities in proparacaine hydrochloride. DOI:10.1016/j.jpba.2020.113497
2. https://pi.bausch.com/globalassets/pdf/PackageInserts/Pharma/Rx-Generics/Proparacaine-HCl-Ophthalmic-Solution.pdf
3. Imming P., Sinning C., Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct; 5(10):821-34. DOI:10.1038/nrd2132
4. T., Levent T., Inci M.A. Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment. Int J Ophthalmol. 2015; 8(5): 938–944. DOI:10.3980/j.issn.2222-3959.2015.05.15
5. Proparacaine Hydrochloride Topical Drop and Intracameral 0.5% Lignocaine for Phacotrabeculectomy in Patients with Primary Open Angle Glaucoma DOI:10.4103/0974-9233.134669
6. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=447a2a64-0507-4fe8-bb44-cc36c3916151&type=display

Proparacaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Proparacaine hydrochloride manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: Proparacaine hydrochloride 5875-06-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500
Release date: 2023-07-14

Shanghai Aosiris new Material Technology Co., LTD

Product: Proparacaine hydrochloride 5875-06-9
Price: US $3.00-1.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10 tons
Release date: 2024-04-19

ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD

Product: Proparacaine Hydrochloride 5875-06-9
Price: US $1.00/mg
Min. Order: 1000mg
Purity: 99
Supply Ability: 5ton/month
Release date: 2022-05-26

5875-06-9, Proparacaine hydrochlorideRelated Search:

PROPARACAINE Denatonium Benzoate Anhydrous Glycine Methoxyammonium chloride AMINOGUANIDINE HYDROCHLORIDE Levomepromazine hydrochloride 4-Aminobenzoic acid 6-Aminocaproic acid Sodium benzoate Imipramine hydrochloride 4-Dimethylaminobenzoic acid ALTRENOGEST Topotecan hydrochloride Ciprofloxacin hydrochloride Pyridine hydrochloride Aminoacetonitrile hydrochloride Emamectin benzoate Triethylamine hydrochloride

2-[(3-amino-4-propoxyphenyl)-oxomethoxy]ethyl-diethylammonium chloride

PROPARACAINE HCL

PROPARACAINE HYDROCHLORIDE

3-amino-4-propoxybenzoicacid2-(diethylamino)ethylesterhydrochloride

alcaine

benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,hydrochloride

benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,monohydrochlorid

beta-(diethylamino)ethyl3-amino-4-n-propoxybenzoatehydrochloride

chibro-heracaine

keracaine

ophthain

ophthainehydrochloride

ophthetic

Proparacaine hydrochloride, >=99%

2-diethylaminoethyl 3-amino-4-propoxy-benzoate hydrochloride

ProxymetacaineHCL2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE

PROXYMETACAINE(2-DIETHYLAMINOETHYL-3-AMINO-4-PROPOXYBENZOATE HYDROCHLORIDE)

PROXYMETACAINEHYDROCHLORIDE/PROPARACAINE

Proparacaine Hydrochloride (200 mg)

3-amino-4-propoxy-benzoic acid-2-(diethylamino)ethyl ester, hydrochloride (1:1)

Proparacaine hydrochloride 2-Diethylaminoethyl 3-amino-4-propoxy-benzoate hydrochloride

2-(3-amino-4-propoxy-benzoyl)oxyethyl-diethyl-ammonium chloride

2-(3-amino-4-propoxybenzoyl)oxyethyl-diethylazanium chloride

2-(3-amino-4-propoxy-phenyl)carbonyloxyethyl-diethyl-azanium chloride

2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride

IN STOCK PROPARACAINE HYDROCHLORIDE CAS 5875-06-9

ProparacaineHydrochloride&gt

Proparacaine HydrochL

Proparacaine hydrochloride USP/EP/BP

Proparacaine hydrochloride Reference Substance

5875-06-9 Proparacaine hydrochloride

Proparacaine Hydrochloride (1571001)

2-(Diethylamino)ethyl ester 3-amino-4-propoxybenzoic acid hydrochloride

Proparacaine HCI

Proparacaine Hydrochloride, ≥ 98.0%

5875-06-9

5875-6-9

C16H26N2O3HCl

Topical ophthalmic anesthetic

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