TYRPHOSTIN A9

Product Name: TYRPHOSTIN A9
CAS No.: 10537-47-0
Chemical Name: TYRPHOSTIN A9
Synonyms: AG 17;CS-743;SF 6847;gcp5126;s-15126;RG 50872;ent27910;MALONABEN;MALONOBEN;Malonobene
CBNumber: CB2245711
Molecular Formula: C18H22N2O
Formula Weight: 282.38
MOL File: 10537-47-0.mol

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TYRPHOSTIN A9 Property

Melting point:: 141-143℃ (ethanol )
Boiling point:: 424.99°C (rough estimate)
Density: 1.0741 (rough estimate)
refractive index: 1.5700 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: ethanol: 20 mg/mL
form: solid
pka: 7.55±0.40(Predicted)
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference: 10537-47-0(CAS DataBase Reference)
EPA Substance Registry System: Malonoben (10537-47-0)

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: OO3737000
HS Code: 2926.90.5050
HazardClass: 6.1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T182
Product name: Tyrphostin A9
Purity: solid
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Sigma-Aldrich

Product number: S481777
Product name: 2-(3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYLIDENE)-MALONONITRILE
Purity: AldrichCPR
Packaging: 25MG
Price: $179
Updated: 2024/03/01

Sigma-Aldrich

Product number: 658425
Product name: AG 17
Packaging: 5mg
Price: $85.2
Updated: 2024/03/01

TCI Chemical

Product number: T3667
Product name: Tyrphostin A9
Purity: >98.0%(GC)
Packaging: 25mg
Price: $69
Updated: 2024/03/01

TCI Chemical

Product number: T3667
Product name: Tyrphostin A9
Purity: >98.0%(GC)
Packaging: 100mg
Price: $206
Updated: 2024/03/01

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TYRPHOSTIN A9 Chemical Properties,Usage,Production

Description

Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4

Uses

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

Uses

SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.

Uses

Selective inhibitor of PDGF receptor tyrosine kinase

Definition

ChEBI: Malonoben is an alkylbenzene. It has a role as a geroprotector.

General Description

A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.

Biological Activity

Potent uncoupler of oxidative phosphorylation.

Biochem/physiol Actions

Cell permeable: yes

References

1) Bilder?et al. (1991),?Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells; Am. J. Physiol.,?260?C721 2) Terada?et al. (1981),?The interaction of highly active uncouplers with mitochondria; Biochim. Biophys. Acta,?639?225 3) Burger?et al. (1995),?Tyrphostin AG17, [3,5-Ditert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria; Cancer Res.,?55?2794 4) Thyberg?et al. (1998),?Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells; Eur. J. Cell Biol.,?76?33

TYRPHOSTIN A9 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN A9 Suppliers

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View Lastest Price from TYRPHOSTIN A9 manufacturers

Career Henan Chemical Co

Product: TYRPHOSTIN A9OLECARBOXYLATE 10537-47-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

10537-47-0, TYRPHOSTIN A9Related Search:

TYRPHOSTIN 25,TYRPHOSTIN A25 TYRPHOSTIN A23,TYRPHOSTIN 23,AG 18 (Tyrphostin A23) TYRPHOSTIN 63,TYRPHOSTIN A63 TYRPHOSTIN A1,TYRPHOSTIN 1 TYRPHOSTIN A51,TYRPHOSTIN 51 AG 213 (Tyrphostin AG 213),TYRPHOSTIN 47,TYRPHOSTIN A47 TYRPHOSTIN AG 1288 TYRPHOSTIN AG 835 TYRPHOSTIN AG 528 TYRPHOSTIN A10 AG 494 (Tyrphostin AG 494) AG 490 (Tyrphostin AG 490) TYRPHOSTIN A9 AG 490 AG 1478 TYRPHOSTIN 957 AG 1295 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)

ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)CINNAMONITRILE

TYRPHOSTIN A9 \ SELECTIVE PDGF TYROSINE

TYRPHOSTIN A9 99+%

Malonobene

2-(3,5-di-tert-butyl-4-hydroxybenzylidene)Malononitrile

Tyrphostin 9 (SF 6847)

Propanedinitrile, 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-

[[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]METHYLENE]-PROPANEDINITRILE

3,5-DI-T-BUTYL-4-HYDROXY-BENZYLIDENEMALONONITRILE

3,5-DI-TERT-BUTYL-4-HYDROXYBENZYLIDENEMALONONITRILE

AG 17

2-[(3,5-DITERT-BUTYL-4-HYDROXYPHENYL)METHYLIDENE]PROPANEDINITRILE

Tyrphostin A9 (AG 17)

2,6-Di-tert-butyl-4-(2,2-dicyanovinyl)phenol

3,5-di-tert-Butyl-4-hydroxybenzylidenemalonitrile

Tyrphostin 9/AG9

TYRPHOSTIN 9;NSC 242557; RG-50872;AG 17; GCP 5126

Tyrphostin 9 (RG-50872, Malonaben, SF 6847)

NSC 242557

SF 6847

RARECHEM AL BX 0198

RG 50872

((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-propanedinitril

2-((3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)methylene)propanedinitrile

3,5-di-tert-butyl-4-hydroxybenzylidene-malononitril

ent27910

gcp5126

gulfs-15126

s-15126

TYRPHOSTIN 9

TYRPHOSTIN A9

TYRPHOSTIN AG 17

TYRPHOSTIN RG 50872

CHEMBRDG-BB 5272363

MALONABEN

MALONOBEN

AG 17 - CAS 10537-47-0 - Calbiochem

Tyrphostin 9(AG-17)

TYRPHOSTIN 9;MALONOBEN;TYRPHOSTIN AG-17;SF 6847;GCP 5126;RG-50872;NSC 242557

CS-743

Tyrphostin9, >98%

TYRPHOSTIN A9OLECARBOXYLATE

Tyrphostin 9 (SF 6847, RG-50872)

[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]malononitrile

TYRPHOSTIN A9 USP/EP/BP

Malonoben Tyrphostin 9

C17896100 Tyrphostin A9

10537-47-0

Inhibitor of calcium release-activated calcium (CRAC) channels (see Dennis et al)

Cell Signaling and Neuroscience

BioChemical

Cell Biology

Kinase/Phosphatase Biology

Receptor Tyrosine Kinase Inhibitors

Platelet Derived Growth Factor Receptor (PDGFR)

Inhibitors