ChemicalBook > CAS DataBase List > LY411575

LY411575

Product Name
LY411575
CAS No.
209984-57-6
Chemical Name
LY411575
Synonyms
CS-509;LY411575;LY4114575;LSN-411575;LY411575, >=98%;LY411575;LY 411575;LY-411575 >=97% (HPLC);LY-411575, 10 mM in DMSO;LY-411575;LY411575; LY 411575;LY411575, 98%, a γ-secretase inhibitor
CBNumber
CB22464309
Molecular Formula
C26H23F2N3O4
Formula Weight
479.48
MOL File
209984-57-6.mol
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LY411575 Property

Boiling point:
836.0±65.0 °C(Predicted)
Density 
1.40
storage temp. 
-20°C
solubility 
DMSO: soluble5mg/mL, clear
pka
11.79±0.20(Predicted)
form 
powder
color 
white to beige
InChIKey
ULSSJYNJIZWPSB-CVRXJBIPSA-N
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0506
Product name
LY-411575
Purity
≥97% (HPLC)
Packaging
5mg
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0506
Product name
LY-411575
Purity
≥97% (HPLC)
Packaging
25mg
Price
$514
Updated
2024/03/01
Cayman Chemical
Product number
16162
Product name
LY411575
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16162
Product name
LY411575
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
16162
Product name
LY411575
Purity
≥98%
Packaging
10mg
Price
$213
Updated
2024/03/01
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LY411575 Chemical Properties,Usage,Production

Description

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.

Uses

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.

Definition

ChEBI: A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N /element>2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.

Biochem/physiol Actions

LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

target

γ-secretase

LY411575 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY411575 Suppliers

China 114 India 1 United Kingdom 1 United States 19 Global 135
AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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info@adooq.com
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United States
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ApexBio Technology LLC
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+1-832-696-8203
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+1-832-641-3177
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United States
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Target molecule Corp.
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857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
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United States
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2559
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Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
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United States
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
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United States
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Cckinase, Inc.
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+1 (732)236-3202
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sales@cckinase.com
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United States
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BOC Sciences
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+1-631-485-4226
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inquiry@bocsci.com
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United States
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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ApexBio Technology
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Cayman Chemical Company
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--
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cayman@caymanchem.com
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Creative Enzymes
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View Lastest Price from LY411575 manufacturers

Career Henan Chemical Co
Product
LY411575 209984-57-6
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
1kg; 10kg; 25kg
Release date
2020-01-07

209984-57-6, LY411575Related Search:

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  • LY411575
  • (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide
  • (S)-2-(2-(3,5-difluorophenyl)acetaMido)-N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanaMide
  • Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-
  • (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LY 411575
  • LY 411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide
  • LSN-411575
  • N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
  • LY411575, >=98%
  • LY-411575;LY411575; LY 411575
  • (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dib
  • LY411575, 98%, a γ-secretase inhibitor
  • CS-509
  • LY411575;LY 411575
  • LY-411575 >=97% (HPLC)
  • LY4114575
  • (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide
  • LY-411575, 10 mM in DMSO
  • 209984-57-6
  • C26H23F2N3O4
  • Inhibitor
  • Inhibitors