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LY411575

Product Name
LY411575
CAS No.
209984-57-6
Chemical Name
LY411575
Synonyms
CS-509;LY411575;LY4114575;LSN-411575;LY411575, >=98%;LY411575;LY 411575;LY-411575 >=97% (HPLC);LY-411575, 10 mM in DMSO;LY-411575;LY411575; LY 411575;LY411575, 98%, a γ-secretase inhibitor
CBNumber
CB22464309
Molecular Formula
C26H23F2N3O4
Formula Weight
479.48
MOL File
209984-57-6.mol
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LY411575 Property

Boiling point:
836.0±65.0 °C(Predicted)
Density 
1.40
storage temp. 
-20°C
solubility 
DMSO: soluble5mg/mL, clear
pka
11.79±0.20(Predicted)
form 
powder
color 
white to beige
InChIKey
ULSSJYNJIZWPSB-CVRXJBIPSA-N
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0506
Product name
LY-411575
Purity
≥97% (HPLC)
Packaging
5mg
Price
$132
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0506
Product name
LY-411575
Purity
≥97% (HPLC)
Packaging
25mg
Price
$528
Updated
2025/07/31
TCI Chemical
Product number
L0359
Product name
LY-411575
Packaging
5MG
Price
$150
Updated
2025/07/31
Cayman Chemical
Product number
16162
Product name
LY411575
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16162
Product name
LY411575
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
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LY411575 Chemical Properties,Usage,Production

Description

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.

Uses

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.

Definition

ChEBI: A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N /element>2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.

Biochem/physiol Actions

LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

target

γ-secretase

References

[1] EVA CZIRR. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.[J]. The Journal of Biological Chemistry, 2007, 282 34: 24504-24513. DOI: 10.1074/jbc.m700618200
[2] CHRISTINE L CURRY. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi”s sarcoma tumor cells[J]. Oncogene, 2005, 24 42: 6333-6344. DOI: 10.1038/sj.onc.1208783
[3] RYUICHI OKAMOTO. Requirement of Notch activation during regeneration of the intestinal epithelia.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2009, 296 1: G23-35. DOI: 10.1152/ajpgi.90225.2008
[4] ELSA ABRANCHES. Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo.[J]. PLoS ONE, 2009: e6286. DOI: 10.1371/journal.pone.0006286

LY411575 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY411575 Suppliers

China 131 India 1 United Kingdom 1 United States 19 Global 152
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
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United States
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ApexBio Technology LLC
Tel
+1-832-696-8203
Fax
+1-832-641-3177
Email
info@apexbt.com
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United States
ProdList
477
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Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
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United States
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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BOC Sciences
Tel
+1-631-485-4226
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1-631-614-7828
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inquiry@bocsci.com
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United States
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Aladdin Scientific
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Email
tp@aladdinsci.com
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United States
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TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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ApexBio Technology
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Cayman Chemical Company
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cayman@caymanchem.com
Country
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Creative Enzymes
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Santa Cruz Biotechnology, Inc.
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scbt@scbt.com
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View Lastest Price from LY411575 manufacturers

Career Henan Chemical Co
Product
LY411575 209984-57-6
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
1kg; 10kg; 25kg
Release date
2020-01-07

209984-57-6, LY411575Related Search:

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  • LY411575
  • (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide
  • (S)-2-(2-(3,5-difluorophenyl)acetaMido)-N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanaMide
  • Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-
  • (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LY 411575
  • LY 411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide
  • LSN-411575
  • N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
  • LY411575, >=98%
  • LY-411575;LY411575; LY 411575
  • (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dib
  • LY411575, 98%, a γ-secretase inhibitor
  • CS-509
  • LY411575;LY 411575
  • LY-411575 >=97% (HPLC)
  • LY4114575
  • (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide
  • LY-411575, 10 mM in DMSO
  • 209984-57-6
  • C26H23F2N3O4
  • Inhibitor
  • Inhibitors