6-Bromo-3-hydroxypicolinicacid
- Product Name
- 6-Bromo-3-hydroxypicolinicacid
- CAS No.
- 321596-58-1
- Chemical Name
- 6-Bromo-3-hydroxypicolinicacid
- Synonyms
- 6-Bromo-3-hydroxypicolinicacid;6-BroMo-3-hydroxypyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-bromo-3-hydroxy-
- CBNumber
- CB22499101
- Molecular Formula
- C6H4BrNO3
- Formula Weight
- 218
- MOL File
- 321596-58-1.mol
6-Bromo-3-hydroxypicolinicacid Property
- Boiling point:
- 485.7±45.0 °C(Predicted)
- Density
- 1.985±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.32±0.25(Predicted)
- Appearance
- Off-white to light yellow Solid
N-Bromosuccinimide Price
- Product number
- B993745
- Product name
- 6-Bromo-3-hydroxypicolinicAcid
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- B993745
- Product name
- 6-Bromo-3-hydroxypicolinicAcid
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 076584
- Product name
- 6-Bromo-3-hydroxypicolinic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $329
- Updated
- 2021/12/16
- Product number
- 076584
- Product name
- 6-Bromo-3-hydroxypicolinic acid
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $214
- Updated
- 2021/12/16
- Product number
- W5403
- Product name
- 6-Bromo-3-hydroxypicolinicacid
- Packaging
- 250mg
- Price
- $398.8
- Updated
- 2021/12/16
6-Bromo-3-hydroxypicolinicacid Chemical Properties,Usage,Production
Synthesis
874-24-8
321596-58-1
General procedure for the synthesis of 6-bromo-3-hydroxypyridine-2-carboxylic acid from 3-hydroxy-2-pyridinecarboxylic acid: to a stirred suspension of 3-hydroxypyridine-2-carboxylic acid (2.00 g, 0.0144 mol) in DMF (30 mL) was slowly added a solution of N-bromosuccinimide (2.56 g, 0.0144 mol) in DMF (30 mL). After 1 h of reaction, water (50 mL) and 1 M NaOH aqueous solution (25 mL) were added, followed by extraction of the reaction mixture with chloroform (3 x 150 mL). The organic layers were combined and concentrated under reduced pressure and the resulting residue was purified by preparative HPLC (System D). The final product 6-bromo-3-hydroxypyridine-2-carboxylic acid was obtained as 366 mg in 12% yield. The product was assayed by analytical HPLC and the purity was 100% in both cases (System A and B); LRESIMS (ESI+) m/z = 218/220 (M + H)+.
References
[1] Patent: WO2009/150144, 2009, A1. Location in patent: Page/Page column 63
6-Bromo-3-hydroxypicolinicacid Preparation Products And Raw materials
Raw materials
Preparation Products
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