6-Bromo-3-hydroxy-2-methylpyridine
- Product Name
- 6-Bromo-3-hydroxy-2-methylpyridine
- CAS No.
- 118399-86-3
- Chemical Name
- 6-Bromo-3-hydroxy-2-methylpyridine
- Synonyms
- 6-broMo-2-Methylpyridin-3-ol;KML-75;KML-36;KML-107;CML-033;6-Bromo-2-methylpyridin-3-o;6-bromo-2-methyl-3-Pyridinol;3-Pyridinol, 6-bromo-2-methyl-;6-Bromo-3-hydoxy-2-methylpyridine;6-Bromo-3-hydroxy-2-methylpyridine
- CBNumber
- CB31471303
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 118399-86-3.mol
6-Bromo-3-hydroxy-2-methylpyridine Property
- Melting point:
- 201-203.5℃
- Boiling point:
- 346.2±37.0 °C(Predicted)
- Density
- 1.655±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.92±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B808153
- Product name
- 6-Bromo-2-methylpyridin-3-ol
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FB140151
- Product name
- 6-Bromo-2-methylpyridin-3-ol
- Packaging
- 1g
- Price
- $141
- Updated
- 2021/12/16
- Product number
- FB140151
- Product name
- 6-Bromo-2-methylpyridin-3-ol
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR941712
- Product name
- 6-Bromo-2-methylpyridin-3-ol
- Purity
- 97%
- Packaging
- 1g
- Price
- $363
- Updated
- 2021/12/16
- Product number
- OR941712
- Product name
- 6-Bromo-2-methylpyridin-3-ol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
6-Bromo-3-hydroxy-2-methylpyridine Chemical Properties,Usage,Production
Synthesis
188923-75-3
118399-86-3
Step 2: Synthesis of 6-bromo-2-methylpyridin-3-ol 4,6-Dibromo-2-methylpyridin-3-ol (15.8 g, 59.4 mmol) was dissolved in tetrahydrofuran (THF, 200 mL). The reaction solution was cooled to -78°C and n-butyllithium (n-BuLi, 50 mL, 125 mmol, 2.5 M hexane solution) was slowly added dropwise at this temperature. After the dropwise addition, the reaction temperature was maintained at -78°C and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with deionized water (50 mL) and the reaction solution was neutralized with 2 N hydrochloric acid (HCl). Subsequently, the aqueous phase was extracted with dichloromethane (2 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford 6-bromo-2-methylpyridin-3-ol (10.5 g, 95% yield) as a yellow oil. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 300 MHz, DMSO-d6): δ 2.29 (s, 3H), 7.08 (d, 1H), 7.26 (d, 1H), 10.08 (s, 1H).
References
[1] Patent: WO2012/112743, 2012, A1. Location in patent: Page/Page column 153-154
[2] Patent: WO2012/125613, 2012, A1. Location in patent: Page/Page column 139
[3] Patent: US2012/196869, 2012, A1. Location in patent: Paragraph 0338; 0339
[4] Patent: WO2013/109521, 2013, A1. Location in patent: Paragraph 00261; 00262
[5] Synlett, 2003, # 11, p. 1678 - 1682
6-Bromo-3-hydroxy-2-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Bromo-3-hydroxy-2-methylpyridine manufacturers
- Product
- 6-Bromo-3-hydroxy-2-methylpyridine 118399-86-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-18