ChemicalBook > CAS DataBase List > 6-Bromo-3-hydroxy-2-methylpyridine

6-Bromo-3-hydroxy-2-methylpyridine

Product Name
6-Bromo-3-hydroxy-2-methylpyridine
CAS No.
118399-86-3
Chemical Name
6-Bromo-3-hydroxy-2-methylpyridine
Synonyms
6-broMo-2-Methylpyridin-3-ol;KML-75;KML-36;KML-107;CML-033;6-Bromo-2-methylpyridin-3-o;6-bromo-2-methyl-3-Pyridinol;3-Pyridinol, 6-bromo-2-methyl-;6-Bromo-3-hydoxy-2-methylpyridine;6-Bromo-3-hydroxy-2-methylpyridine
CBNumber
CB31471303
Molecular Formula
C6H6BrNO
Formula Weight
188.02
MOL File
118399-86-3.mol
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6-Bromo-3-hydroxy-2-methylpyridine Property

Melting point:
201-203.5℃
Boiling point:
346.2±37.0 °C(Predicted)
Density 
1.655±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
9.92±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
B808153
Product name
6-Bromo-2-methylpyridin-3-ol
Packaging
500mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140151
Product name
6-Bromo-2-methylpyridin-3-ol
Packaging
500mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140151
Product name
6-Bromo-2-methylpyridin-3-ol
Packaging
1g
Price
$141
Updated
2021/12/16
Apolloscientific
Product number
OR941712
Product name
6-Bromo-2-methylpyridin-3-ol
Purity
97%
Packaging
250mg
Price
$218
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140151
Product name
6-Bromo-2-methylpyridin-3-ol
Packaging
2g
Price
$246
Updated
2021/12/16
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6-Bromo-3-hydroxy-2-methylpyridine Chemical Properties,Usage,Production

Synthesis

188923-75-3

118399-86-3

Step 2: Synthesis of 6-bromo-2-methylpyridin-3-ol 4,6-Dibromo-2-methylpyridin-3-ol (15.8 g, 59.4 mmol) was dissolved in tetrahydrofuran (THF, 200 mL). The reaction solution was cooled to -78°C and n-butyllithium (n-BuLi, 50 mL, 125 mmol, 2.5 M hexane solution) was slowly added dropwise at this temperature. After the dropwise addition, the reaction temperature was maintained at -78°C and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with deionized water (50 mL) and the reaction solution was neutralized with 2 N hydrochloric acid (HCl). Subsequently, the aqueous phase was extracted with dichloromethane (2 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford 6-bromo-2-methylpyridin-3-ol (10.5 g, 95% yield) as a yellow oil. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 300 MHz, DMSO-d6): δ 2.29 (s, 3H), 7.08 (d, 1H), 7.26 (d, 1H), 10.08 (s, 1H).

References

[1] Patent: WO2012/112743, 2012, A1. Location in patent: Page/Page column 153-154
[2] Patent: WO2012/125613, 2012, A1. Location in patent: Page/Page column 139
[3] Patent: US2012/196869, 2012, A1. Location in patent: Paragraph 0338; 0339
[4] Patent: WO2013/109521, 2013, A1. Location in patent: Paragraph 00261; 00262
[5] Synlett, 2003, # 11, p. 1678 - 1682

6-Bromo-3-hydroxy-2-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Bromo-3-hydroxy-2-methylpyridine manufacturers

Career Henan Chemical Co
Product
6-Bromo-3-hydroxy-2-methylpyridine 118399-86-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-12-18

118399-86-3, 6-Bromo-3-hydroxy-2-methylpyridineRelated Search:

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  • 6-bromo-2-methyl-3-Pyridinol
  • 6-Bromo-3-hydoxy-2-methylpyridine
  • 6-Bromo-3-hydroxy-2-methylpyridine
  • 6-broMo-2-Methylpyridin-3-ol
  • 6-Bromo-2-methylpyridin-3-o
  • CML-033
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  • 2-bromo-5-hydroxyl-6-methylpyridine
  • KML-36
  • KML-75
  • KML-107
  • 118399-86-3