ChemicalBook > CAS DataBase List > 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

Product Name
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
CAS No.
440122-66-7
Chemical Name
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
Synonyms
WAY 200070;WAY200070;WAY 200070;7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol;5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-;7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol;7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol;Estrogen Receptor/ERR,WAY200070,WAY-200070,Inhibitor,inhibit
CBNumber
CB22518907
Molecular Formula
C13H8BrNO3
Formula Weight
306.11
MOL File
440122-66-7.mol
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7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Property

Boiling point:
463.6±35.0 °C(Predicted)
Density 
1.720±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: ≥20mg/mL
form 
solid
pka
7.26±0.40(Predicted)
color 
White to off-white
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Safety

Hazard Codes 
T
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
6.1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W1520
Product name
WAY-200070
Purity
≥98% (HPLC)
Packaging
5mg
Price
$115
Updated
2024/03/01
Sigma-Aldrich
Product number
W1520
Product name
WAY-200070
Purity
≥98% (HPLC)
Packaging
25mg
Price
$441
Updated
2024/03/01
Alfa Aesar
Product number
J67375
Product name
WAY-200070
Packaging
10mg
Price
$204
Updated
2023/06/20
Cayman Chemical
Product number
23323
Product name
WAY-200070
Purity
≥98%
Packaging
5mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
23323
Product name
WAY-200070
Purity
≥98%
Packaging
10mg
Price
$134
Updated
2024/03/01
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7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Chemical Properties,Usage,Production

Uses

WAY 200070 is an aryl diphenolic azole and a selective ERβ agonist. This compound is suitable for estrogen receptor signaling research.

Biological Activity

WAY-200070 is a selective estrogen receptor agonist with IC50 of 2.3 nM.

in vivo

Administration of WAY-200070 (30 mg/kg sc) causes nuclear translocation of ERRβ receptors in WT mice. Administration of it produces a delayed 50% increase in dopamine in the striatum of wild type mice. It reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070 , shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.

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target

IC50: 2.3 nM (ERRβ), 155 nM (ERRα)

7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Suppliers

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View Lastest Price from 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
WAY-200070 440122-66-7
Price
US $100.00/g
Min. Order
1mg
Purity
99%
Supply Ability
100g 10kgs
Release date
2021-12-21
Wuhan Senwayer Century Chemical Co.,Ltd
Product
WAY 200070 440122-66-7
Price
US $1300.00-11000.00/gram
Min. Order
10gram
Purity
99%
Supply Ability
2 tons
Release date
2022-10-31

440122-66-7, 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-olRelated Search:

WAY 181187 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester SAM-315 N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE WAY 100635 1,3-Benzenediol, 4-[1-(2-propenyl)-7-(trifluoromethyl)-1H-indazol-3-yl]- 1-Bromopropane Bromopropylate 2-Bromo-4-butanolide BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) WAY 208466 dihydrochloride WAY-204688 WAY-600 MAY-262611 WAY-151932 Raloxifene hydrochloride 2-METHOXYESTRADIOL

  • 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
  • WAY 200070
  • 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
  • WAY200070;WAY 200070
  • 5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-
  • 7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol
  • Estrogen Receptor/ERR,WAY200070,WAY-200070,Inhibitor,inhibit
  • 440122-66-7